DOI: 10.1126/science.8128249. Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

10.1126/science.8128249

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

T lymphocyte maturation is dependent on interactions between the T cell receptor (TCR) expressed on the developing thymocyte and intrathymic major histocompatibility complex (MHC)-peptide ligands. The relation between the peptide-MHC complex that results in negative or positive selection has not been identified. Here, the requirements for the maturation of thymocytes expressing a defined transgenic TCR specific for a viral peptide are studied in fetal thymic organ culture. Low concentrations of the viral peptide antigen recognized by this transgenic TCR can mediate positive selection, whereas high concentrations result in thymocyte tolerance. These findings support the affinity-avidity model of thymocyte selection.

Bibliography

Sebzda, E., Wallace, V. A., Mayer, J., Yeung, R. S. M., Mak, T. W., & Ohashi, P. S. (1994). Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide. Science, 263(5153), 1615â1618.

Authors 6

Eric Sebzda (first)
Valerie A. Wallace (additional)
John Mayer (additional)
Rae S. M. Yeung (additional)
Tak W. Mak (additional)
Pamela S. Ohashi (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:01 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:14 p.m.)
Indexed	2 months, 3 weeks ago (June 3, 2025, 5:25 p.m.)
Issued	31 years, 5 months ago (March 18, 1994)
Published	31 years, 5 months ago (March 18, 1994)
Published Print	31 years, 5 months ago (March 18, 1994)

Funders 0

None

BibTeX

@article{Sebzda_1994, title={Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide}, volume={263}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8128249}, DOI={10.1126/science.8128249}, number={5153}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Sebzda, Eric and Wallace, Valerie A. and Mayer, John and Yeung, Rae S. M. and Mak, Tak W. and Ohashi, Pamela S.}, year={1994}, month=mar, pages={1615–1618} }

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