NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway
10.1126/science.8096091
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The eukaryotic transcription factor nuclear factor-kappa B (NF-κB) participates in many parts of the genetic program mediating T lymphocyte activation and growth. Nuclear expression of NF-κB occurs after its induced dissociation from its cytoplasmic inhibitor IκBα. Phorbol ester and tumor necrosis factor-alpha induction of nuclear NF-κB is associated with both the degradation of performed IκBα and the activation of IκBα gene expression. Transfection studies indicate that the IκBα gene is specifically induced by the 65-kilodalton transactivating subunit of NF-κB. Association of the newly synthesized IκBα with p65 restores intracellular inhibition of NF-κB DNA binding activity and prolongs the survival of this labile inhibitor. Together, these results show that NF-κB controls the expression of IκBα by means of an inducible autoregulatory pathway.

Bibliography

Sun, S.-C., Ganchi, P. A., Ballard, D. W., & Greene, W. C. (1993). NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway. Science, 259(5103), 1912–1915.

Authors 4
  1. Shao-Cong Sun (first)
  2. Parham A. Ganchi (additional)
  3. Dean W. Ballard (additional)
  4. Warner C. Greene (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 7:05 p.m.)
Deposited 1 year, 7 months ago (Jan. 15, 2024, 12:27 a.m.)
Indexed 3 weeks, 2 days ago (Aug. 7, 2025, 4:58 p.m.)
Issued 32 years, 5 months ago (March 26, 1993)
Published 32 years, 5 months ago (March 26, 1993)
Published Print 32 years, 5 months ago (March 26, 1993)
Funders 0

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@article{Sun_1993, title={NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway}, volume={259}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8096091}, DOI={10.1126/science.8096091}, number={5103}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Sun, Shao-Cong and Ganchi, Parham A. and Ballard, Dean W. and Greene, Warner C.}, year={1993}, month=mar, pages={1912–1915} }