Genetic Dissection of Complex Traits
10.1126/science.8091226
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Medical genetics was revolutionized during the 1980s by the application of genetic mapping to locate the genes responsible for simple Mendelian diseases. Most diseases and traits, however, do not follow simple inheritance patterns. Geneticists have thus begun taking up the even greater challenge of the genetic dissection of complex traits. Four major approaches have been developed: linkage analysis, allele-sharing methods, association studies, and polygenic analysis of experimental crosses. This article synthesizes the current state of the genetic dissection of complex traits—describing the methods, limitations, and recent applications to biological problems.

Bibliography

Lander, E. S., & Schork, N. J. (1994). Genetic Dissection of Complex Traits. Science, 265(5181), 2037–2048.

Authors 2
  1. Eric S. Lander (first)
  2. Nicholas J. Schork (additional)
References 271 Referenced 2,117
  1. 10.1126/science.8484121
  2. AMOS, C.I., THE PROBABILISTIC DETERMINATION OF IDENTITY-BY-DESCENT SHARING FOR PAIRS OF RELATIVES FROM PEDIGREES, AMERICAN JOURNAL OF HUMAN GENETICS 47: 842 (1990). / AMERICAN JOURNAL OF HUMAN GENETICS (1990)
  3. AMOS, C.I., ROBUSTNESS OF THE MAXIMUM-LIKELIHOOD (LOD) METHOD FOR DETECTING LINKAGE, AMERICAN JOURNAL OF HUMAN GENETICS 52: 213 (1993). / AMERICAN JOURNAL OF HUMAN GENETICS (1993)
  4. AMOS, C.I., ROBUST VARIANCE-COMPONENTS APPROACH FOR ASSESSING GENETIC-LINKAGE IN PEDIGREES, AMERICAN JOURNAL OF HUMAN GENETICS 54: 535 (1994). / AMERICAN JOURNAL OF HUMAN GENETICS (1994)
  5. AMOS, C.I., AN APPROACH TO THE MULTIVARIATE-ANALYSIS OF HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL IN A LARGE KINDRED - THE BOGALUSA HEART-STUDY, GENETIC EPIDEMIOLOGY 3: 255 (1986). (10.1002/gepi.1370030406) / GENETIC EPIDEMIOLOGY (1986)
  6. AMOS, C.I., ROBUST METHODS FOR THE DETECTION OF GENETIC-LINKAGE FOR QUANTITATIVE DATA FROM PEDIGREES, GENETIC EPIDEMIOLOGY 6: 349 (1989). (10.1002/gepi.1370060205) / GENETIC EPIDEMIOLOGY (1989)
  7. ARINAMI, T, ASSOCIATION BETWEEN SEVERITY OF ALCOHOLISM AND THE A1-ALLELE OF THE DOPAMINE D2-RECEPTOR GENE TAQI-A RFLP IN JAPANESE, BIOLOGICAL PSYCHIATRY 33: 108 (1993). (10.1016/0006-3223(93)90309-2) / BIOLOGICAL PSYCHIATRY (1993)
  8. BARBOSA, J, DIABETIC METAB 2: 160 (1976). / DIABETIC METAB (1976)
  9. BARNARD, G. A., JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY 11: 115 (1949). (10.1111/j.2517-6161.1949.tb00028.x) / JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY (1949)
  10. BARON, M, DIMINISHED SUPPORT FOR LINKAGE BETWEEN MANIC-DEPRESSIVE ILLNESS AND X-CHROMOSOME MARKERS IN 3 ISRAELI PEDIGREES, NATURE GENETICS 3: 49 (1993). (10.1038/ng0193-49) / NATURE GENETICS (1993)
  11. Beckman, J. S., Gene Mapping Techniques and Applications: 201 (1991). / Gene Mapping Techniques and Applications (1991)
  12. BELKNAP, J.K., EMPIRICAL ESTIMATES OF BONFERRONI CORRECTIONS FOR USE IN CHROMOSOME MAPPING STUDIES WITH THE BXD RECOMBINANT INBRED STRAINS, BEHAVIOR GENETICS 22: 677 (1992). (10.1007/BF01066638) / BEHAVIOR GENETICS (1992)
  13. BELL, G.I., GENE FOR NON-INSULIN-DEPENDENT DIABETES-MELLITUS (MATURITY-ONSET DIABETES OF THE YOUNG SUBTYPE) IS LINKED TO DNA POLYMORPHISM ON HUMAN CHROMOSOME-20Q, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 1484 (1991). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1991)
  14. 10.1016/S0022-2836(83)80320-9
  15. BERRETTINI, W.H., CHROMOSOME-18 DNA MARKERS AND MANIC-DEPRESSIVE ILLNESS - EVIDENCE FOR A SUSCEPTIBILITY GENE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 5918 (1994). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1994)
  16. BISHOP, D.T., THE POWER OF IDENTITY-BY-STATE METHODS FOR LINKAGE ANALYSIS, AMERICAN JOURNAL OF HUMAN GENETICS 46: 254 (1990). / AMERICAN JOURNAL OF HUMAN GENETICS (1990)
  17. 10.1002/gepi.1370050303
  18. BLACKWELDER, W. C., COMMUNICATIONS IN STATISTICS PART A-THEORY AND METHODS 11: 449 (1982). (10.1080/03610928208828250) / COMMUNICATIONS IN STATISTICS PART A-THEORY AND METHODS (1982)
  19. BLACKWELDER, W.C., GENET EPIDEMIOL 2: 85 (1985). (10.1002/gepi.1370020109) / GENET EPIDEMIOL (1985)
  20. BLEEKERWAGEMAKE.LM, EVIDENCE FOR NONALLELIC GENETIC-HETEROGENEITY IN AUTOSOMAL RECESSIVE RETINITIS-PIGMENTOSA, GENOMICS 14: 811 (1992). (10.1016/S0888-7543(05)80195-8) / GENOMICS (1992)
  21. BLUM, K, GENETIC PREDISPOSITION IN ALCOHOLISM - ASSOCIATION OF THE D2 DOPAMINE RECEPTOR TAQI B1 RFLP WITH SEVERE ALCOHOLICS, ALCOHOL 10: 59 (1993). (10.1016/0741-8329(93)90054-R) / ALCOHOL (1993)
  22. 10.1001/jama.1990.03440150063027
  23. BOEHNKE, M, ESTIMATING THE POWER OF A PROPOSED LINKAGE STUDY - A PRACTICAL COMPUTER-SIMULATION APPROACH, AMERICAN JOURNAL OF HUMAN GENETICS 39: 513 (1986). / AMERICAN JOURNAL OF HUMAN GENETICS (1986)
  24. BOEHNKE, M, COMPARISON OF SEQUENTIAL AND FIXED-STRUCTURE SAMPLING OF PEDIGREES IN COMPLEX SEGREGATION ANALYSIS OF A QUANTITATIVE TRAIT, AMERICAN JOURNAL OF HUMAN GENETICS 43: 336 (1988). / AMERICAN JOURNAL OF HUMAN GENETICS (1988)
  25. BOEHNKE, M, SELECTING PEDIGREES FOR LINKAGE ANALYSIS OF A QUANTITATIVE TRAIT - THE EXPECTED NUMBER OF INFORMATIVE MEIOSES, AMERICAN JOURNAL OF HUMAN GENETICS 46: 581 (1990). / AMERICAN JOURNAL OF HUMAN GENETICS (1990)
  26. BOEHNKE, M, LIMITS OF RESOLUTION OF GENETIC-LINKAGE STUDIES - IMPLICATIONS FOR THE POSITIONAL CLONING OF HUMAN-DISEASE GENES, AMERICAN JOURNAL OF HUMAN GENETICS 55: 379 (1994). / AMERICAN JOURNAL OF HUMAN GENETICS (1994)
  27. BOERWINKLE, E, THE USE OF MEASURED GENOTYPE INFORMATION IN THE ANALYSIS OF QUANTITATIVE PHENOTYPES IN MAN .1. MODELS AND ANALYTICAL METHODS, ANNALS OF HUMAN GENETICS 50: 181 (1986). (10.1111/j.1469-1809.1986.tb01037.x) / ANNALS OF HUMAN GENETICS (1986)
  28. BONNEY, G.E., COMBINED LINKAGE AND SEGREGATION ANALYSIS USING REGRESSIVE MODELS, AMERICAN JOURNAL OF HUMAN GENETICS 43: 29 (1988). / AMERICAN JOURNAL OF HUMAN GENETICS (1988)
  29. BONNEY, G.E., ON THE STATISTICAL DETERMINATION OF MAJOR GENE MECHANISMS IN CONTINUOUS HUMAN TRAITS - REGRESSIVE MODELS, AMERICAN JOURNAL OF MEDICAL GENETICS 18: 731 (1984). (10.1002/ajmg.1320180420) / AMERICAN JOURNAL OF MEDICAL GENETICS (1984)
  30. BOTSTEIN, D, CONSTRUCTION OF A GENETIC-LINKAGE MAP IN MAN USING RESTRICTION FRAGMENT LENGTH POLYMORPHISMS, AMERICAN JOURNAL OF HUMAN GENETICS 32: 314 (1980). / AMERICAN JOURNAL OF HUMAN GENETICS (1980)
  31. BOWDEN, D.W., LINKAGE ANALYSIS OF MATURITY-ONSET DIABETES OF THE YOUNG (MODY) - GENETIC-HETEROGENEITY AND NONPENETRANCE, AMERICAN JOURNAL OF HUMAN GENETICS 50: 607 (1992). / AMERICAN JOURNAL OF HUMAN GENETICS (1992)
  32. Braun W. E. HLA and Disease (1979).
  33. BROWN, D.L., EFFICIENT STRATEGIES FOR GENOMIC SEARCHING USING THE AFFECTED-PEDIGREE-MEMBER METHOD OF LINKAGE ANALYSIS, AMERICAN JOURNAL OF HUMAN GENETICS 54: 544 (1994). / AMERICAN JOURNAL OF HUMAN GENETICS (1994)
  34. BRUL, S, GENETIC-HETEROGENEITY IN THE CEREBROHEPATORENAL (ZELLWEGER) SYNDROME AND OTHER INHERITED DISORDERS WITH A GENERALIZED IMPAIRMENT OF PEROXISOMAL FUNCTIONS - A STUDY USING COMPLEMENTATION ANALYSIS, JOURNAL OF CLINICAL INVESTIGATION 81: 1710 (1988). (10.1172/JCI113510) / JOURNAL OF CLINICAL INVESTIGATION (1988)
  35. CAMBIEN, F, DELETION POLYMORPHISM IN THE GENE FOR ANGIOTENSIN-CONVERTING ENZYME IS A POTENT RISK FACTOR FOR MYOCARDIAL-INFARCTION, NATURE 359: 641 (1992). (10.1038/359641a0) / NATURE (1992)
  36. CANNINGS, C, PROBABILITY FUNCTIONS ON COMPLEX PEDIGREES, ADVANCES IN APPLIED PROBABILITY 10: 26 (1978). (10.2307/1426718) / ADVANCES IN APPLIED PROBABILITY (1978)
  37. CANNINGS, C, ASCERTAINMENT IN SEQUENTIAL SAMPLING OF PEDIGREES, CLINICAL GENETICS 12: 208 (1977). (10.1111/j.1399-0004.1977.tb00928.x) / CLINICAL GENETICS (1977)
  38. CARBONELL, E.A., INTERVAL MAPPING IN THE ANALYSIS OF NONADDITIVE QUANTITATIVE TRAIT LOCI, BIOMETRICS 48: 305 (1992). (10.2307/2532757) / BIOMETRICS (1992)
  39. Cardon L. R. American Journal of Human Genetics in press.
  40. CAREY, G, LINKAGE ANALYSIS OF QUANTITATIVE TRAITS - INCREASED POWER BY USING SELECTED SAMPLES, AMERICAN JOURNAL OF HUMAN GENETICS 49: 786 (1991). / AMERICAN JOURNAL OF HUMAN GENETICS (1991)
  41. CASTLE, W.E., SCIENCE 54: 223 (1921). (10.1126/science.54.1393.223.a) / SCIENCE (1921)
  42. CHAKRABORTY, R, ADMIXTURE AS A TOOL FOR FINDING LINKED GENES AND DETECTING THAT DIFFERENCE FROM ALLELIC ASSOCIATION BETWEEN LOCI, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 9119 (1988). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1988)
  43. Chernoff, H., Journal of Statistical Planning and Inference 43: 19 (1995). (10.1016/0378-3758(94)00006-H) / Journal of Statistical Planning and Inference (1995)
  44. CHIANO, M. N., ANNALS OF HUMAN GENETICS 58: 129 (1994). (10.1111/j.1469-1809.1994.tb01882.x) / ANNALS OF HUMAN GENETICS (1994)
  45. CHOTAI, J, ON THE LOD SCORE METHOD IN LINKAGE ANALYSIS, ANNALS OF HUMAN GENETICS 48: 359 (1984). (10.1111/j.1469-1809.1984.tb00849.x) / ANNALS OF HUMAN GENETICS (1984)
  46. CLARK, R.F., MOLECULAR-GENETICS OF ALZHEIMERS-DISEASE, ARCHIVES OF NEUROLOGY 50: 1164 (1993). (10.1001/archneur.1993.00540110044004) / ARCHIVES OF NEUROLOGY (1993)
  47. CLAUS, E.B., AGE AT ONSET AS AN INDICATOR OF FAMILIAL RISK OF BREAST-CANCER, AMERICAN JOURNAL OF EPIDEMIOLOGY 131: 961 (1990). (10.1093/oxfordjournals.aje.a115616) / AMERICAN JOURNAL OF EPIDEMIOLOGY (1990)
  48. CLERGET-DARPOUX, F, ANNALS OF HUMAN GENETICS 46: 363 (1982). (10.1111/j.1469-1809.1982.tb01587.x) / ANNALS OF HUMAN GENETICS (1982)
  49. CLERGETDARPOUX, F, A NEW METHOD TO TEST GENETIC MODELS IN HLA ASSOCIATED DISEASES - THE MASC METHOD, ANNALS OF HUMAN GENETICS 52: 247 (1988). (10.1111/j.1469-1809.1988.tb01102.x) / ANNALS OF HUMAN GENETICS (1988)
  50. CLERGETDARPOUX, F, EFFECTS OF MIS-SPECIFYING GENETIC-PARAMETERS IN LOD SCORE ANALYSIS, BIOMETRICS 42: 393 (1986). (10.2307/2531059) / BIOMETRICS (1986)
  51. CLERGETDARPOUX, F, POWER AND ROBUSTNESS OF THE LINKAGE HOMOGENEITY TEST IN GENETIC-ANALYSIS OF COMMON DISORDERS, JOURNAL OF PSYCHIATRIC RESEARCH 21: 625 (1987). (10.1016/0022-3956(87)90113-0) / JOURNAL OF PSYCHIATRIC RESEARCH (1987)
  52. COLLINS F COMMUNICATION.
  53. COOPER, D.N., MOLECULAR GENETIC APPROACHES TO THE ANALYSIS AND DIAGNOSIS OF HUMAN INHERITED DISEASE - AN OVERVIEW, ANNALS OF MEDICINE 24: 29 (1992). (10.3109/07853899209164142) / ANNALS OF MEDICINE (1992)
  54. CORDER, E.H., PROTECTIVE EFFECT OF APOLIPOPROTEIN-E TYPE-2 ALLELE FOR LATE-ONSET ALZHEIMER-DISEASE, NATURE GENETICS 7: 180 (1994). (10.1038/ng0694-180) / NATURE GENETICS (1994)
  55. 10.1126/science.8346443
  56. COTTINGHAM, R.W., FASTER SEQUENTIAL GENETIC-LINKAGE COMPUTATIONS, AMERICAN JOURNAL OF HUMAN GENETICS 53: 252 (1993). / AMERICAN JOURNAL OF HUMAN GENETICS (1993)
  57. 10.1126/science.8209252
  58. DARVASI, A, DETECTING MARKER-QTL LINKAGE AND ESTIMATING QTL GENE EFFECT AND MAP LOCATION USING A SATURATED GENETIC-MAP, GENETICS 134: 943 (1993). (10.1093/genetics/134.3.943) / GENETICS (1993)
  59. Davies, J., Nature 371: 130 (1994). (10.1038/371130a0) / Nature (1994)
  60. DETERAWADLEIGH, S.D., EXCLUSION OF LINKAGE TO 5Q11-13 IN FAMILIES WITH SCHIZOPHRENIA AND OTHER PSYCHIATRIC-DISORDERS, NATURE 340: 391 (1989). (10.1038/340391a0) / NATURE (1989)
  61. DE WEERD-KASTELEIN, EA, , NATURE-NEW BIOLOGY 238: 80 (1972). (10.1038/newbio238080a0) / NATURE-NEW BIOLOGY (1972)
  62. 10.1016/0092-8674(93)90484-8
  63. DOVER, G.J., FETAL HEMOGLOBIN LEVELS IN SICKLE-CELL DISEASE AND NORMAL INDIVIDUALS ARE PARTIALLY CONTROLLED BY AN X-LINKED GENE LOCATED AT XP22.2, BLOOD 80: 816 (1992). (10.1182/blood.V80.3.816.816) / BLOOD (1992)
  64. DURNER, M, INTERFAMILIAL AND INTRAFAMILIAL HETEROGENEITY - EFFECTIVE SAMPLING STRATEGIES AND COMPARISON OF ANALYSIS-METHODS, AMERICAN JOURNAL OF HUMAN GENETICS 51: 859 (1992). / AMERICAN JOURNAL OF HUMAN GENETICS (1992)
  65. EASTON, D, INHERITED SUSCEPTIBILITY TO BREAST-CANCER, CANCER SURVEYS 18: 95 (1993). / CANCER SURVEYS (1993)
  66. EAVES, L. J., HEREDITY 72: 175 (1994). (10.1038/hdy.1994.25) / HEREDITY (1994)
  67. Edgington E. S. Randomization Tests (1987).
  68. Edwards A. W. F. Likelihood (1992). (10.56021/9780801844454)
  69. Edwards, J, Cytogenetic and Genome Research 32: 43 (1982). (10.1159/000131685) / Cytogenetic and Genome Research (1982)
  70. EDWARDS, J.H., ACTA GENETICA STATIS 10: 63 (1960). / ACTA GENETICA STATIS (1960)
  71. EDWARDS, J.H., FAMILIAL PREDISPOSITION IN MAN, BRITISH MEDICAL BULLETIN 25: 58 (1969). (10.1093/oxfordjournals.bmb.a070672) / BRITISH MEDICAL BULLETIN (1969)
  72. Efron, B., An Introduction to the Bootstrap: 220 (1994). / An Introduction to the Bootstrap (1994)
  73. EGELAND, J.A., BIPOLAR AFFECTIVE-DISORDERS LINKED TO DNA MARKERS ON CHROMOSOME-11, NATURE 325: 783 (1987). (10.1038/325783a0) / NATURE (1987)
  74. Elston, R. C., Human Heredity 21: 523 (1971). (10.1159/000152448) / Human Heredity (1971)
  75. ELSTON, R.C., THE ELSTON-STEWART ALGORITHM FOR CONTINUOUS GENOTYPES AND ENVIRONMENTAL-FACTORS, HUMAN HEREDITY 42: 16 (1992). (10.1159/000154043) / HUMAN HEREDITY (1992)
  76. Elston, R. C., Proceedings of the 16th International Biometric Conference: 39 (1992). / Proceedings of the 16th International Biometric Conference (1992)
  77. EWENS, W.J., ASPECTS OF PARAMETER-ESTIMATION IN ASCERTAINMENT SAMPLING SCHEMES, AMERICAN JOURNAL OF HUMAN GENETICS 34: 853 (1982). / AMERICAN JOURNAL OF HUMAN GENETICS (1982)
  78. EWENS, W. J., ANNALS OF HUMAN GENETICS 50: 399 (1986). (10.1111/j.1469-1809.1986.tb01760.x) / ANNALS OF HUMAN GENETICS (1986)
  79. Falconer D. S. Introduction to Quantitative Genetics (1981).
  80. FALK, C.T., HAPLOTYPE RELATIVE RISKS - AN EASY RELIABLE WAY TO CONSTRUCT A PROPER CONTROL SAMPLE FOR RISK CALCULATIONS, ANNALS OF HUMAN GENETICS 51: 227 (1987). (10.1111/j.1469-1809.1987.tb00875.x) / ANNALS OF HUMAN GENETICS (1987)
  81. FARAWAY, J.J., DISTRIBUTION OF THE ADMIXTURE TEST FOR THE DETECTION OF LINKAGE UNDER HETEROGENEITY, GENETIC EPIDEMIOLOGY 10: 75 (1993). (10.1002/gepi.1370100108) / GENETIC EPIDEMIOLOGY (1993)
  82. FEINGOLD, E, GAUSSIAN MODELS FOR GENETIC-LINKAGE ANALYSIS USING COMPLETE HIGH-RESOLUTION MAPS OF IDENTITY BY DESCENT, AMERICAN JOURNAL OF HUMAN GENETICS 53: 234 (1993). / AMERICAN JOURNAL OF HUMAN GENETICS (1993)
  83. Feldman, M. W., Genetic Aspects of Common Diseases: Applications to Predictive Factors in Coronary Disease: 203 (1979). / Genetic Aspects of Common Diseases: Applications to Predictive Factors in Coronary Disease (1979)
  84. Festing M. F. W. Inbred Strains in Biomedical Research (1979). (10.1007/978-1-349-03816-9)
  85. FISHEL, R, THE HUMAN MUTATOR GENE HOMOLOG MSH2 AND ITS ASSOCIATION WITH HEREDITARY NONPOLYPOSIS COLON-CANCER, CELL 75: 1027 (1993). (10.1016/0092-8674(93)90546-3) / CELL (1993)
  86. FISHEL, R, CELL 77: 167 (1994). (10.1016/0092-8674(94)90306-9) / CELL (1994)
  87. Fisher, R. A., Transactions of the Royal Society of Edinburgh 52: 399 (1918). / Transactions of the Royal Society of Edinburgh (1918)
  88. FORD, D, RISKS OF CANCER IN BRCA1-MUTATION CARRIERS, LANCET 343: 692 (1994). (10.1016/S0140-6736(94)91578-4) / LANCET (1994)
  89. Frankel, W. N., Genetics 138: 481 (1994). (10.1093/genetics/138.2.481) / Genetics (1994)
  90. 10.1038/356162a0
  91. FULKER, D.W., A SIB-PAIR APPROACH TO INTERVAL MAPPING OF QUANTITATIVE TRAIT LOCI, AMERICAN JOURNAL OF HUMAN GENETICS 54: 1092 (1994). / AMERICAN JOURNAL OF HUMAN GENETICS (1994)
  92. GARTNER, J, MUTATIONS IN THE 70K PEROXISOMAL MEMBRANE-PROTEIN GENE IN ZELLWEGER SYNDROME, NATURE GENETICS 1: 16 (1992). (10.1038/ng0492-16) / NATURE GENETICS (1992)
  93. 10.1001/jama.1991.03470130081033
  94. GELERNTER, J, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 269: 1673 (1993). (10.1001/jama.1993.03500130087038) / JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (1993)
  95. GEORGE, V.T., TESTING THE ASSOCIATION BETWEEN POLYMORPHIC MARKERS AND QUANTITATIVE TRAITS IN PEDIGREES, GENETIC EPIDEMIOLOGY 4: 193 (1987). (10.1002/gepi.1370040304) / GENETIC EPIDEMIOLOGY (1987)
  96. Ghosh, J. K., The Proceedings of the Berkeley Conference in Honor of Jerzy Neyman and Jack Kiefer: 807 (1985). / The Proceedings of the Berkeley Conference in Honor of Jerzy Neyman and Jack Kiefer (1985)
  97. GHOSH, S, POLYGENIC CONTROL OF AUTOIMMUNE DIABETES IN NONOBESE DIABETIC MICE, NATURE GENETICS 4: 404 (1993). (10.1038/ng0893-404) / NATURE GENETICS (1993)
  98. GOLDGAR, D.E., MULTIPOINT ANALYSIS OF HUMAN QUANTITATIVE GENETIC-VARIATION, AMERICAN JOURNAL OF HUMAN GENETICS 47: 957 (1990). / AMERICAN JOURNAL OF HUMAN GENETICS (1990)
  99. GOLDMAN, D, D2 DOPAMINE RECEPTOR GENOTYPE AND CEREBROSPINAL-FLUID HOMOVANILLIC-ACID, 5-HYDROXYINDOLEACETIC ACID AND 3-METHOXY-4-HYDROXYPHENYLGLYCOL IN ALCOHOLICS IN FINLAND AND THE UNITED-STATES, ACTA PSYCHIATRICA SCANDINAVICA 86: 351 (1992). (10.1111/j.1600-0447.1992.tb03279.x) / ACTA PSYCHIATRICA SCANDINAVICA (1992)
  100. GOLDMAN, D, DRD2 DOPAMINE RECEPTOR GENOTYPE, LINKAGE DISEQUILIBRIUM, AND ALCOHOLISM IN AMERICAN-INDIANS AND OTHER POPULATIONS, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 17: 199 (1993). (10.1111/j.1530-0277.1993.tb00749.x) / ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (1993)
  101. Goldman, D., Alcoholism: Clinical and Experimental Research 19: 824 (1995). (10.1111/j.1530-0277.1995.tb00953.x) / Alcoholism: Clinical and Experimental Research (1995)
  102. GORADIA, T.M., FAST COMPUTATION OF GENETIC LIKELIHOODS ON HUMAN PEDIGREE DATA, HUMAN HEREDITY 42: 42 (1992). (10.1159/000154045) / HUMAN HEREDITY (1992)
  103. GROOP L COMMUNICATION.
  104. GROOT, P.C., THE RECOMBINANT CONGENIC STRAINS FOR ANALYSIS OF MULTIGENIC TRAITS - GENETIC COMPOSITION, FASEB JOURNAL 6: 2826 (1992). (10.1096/fasebj.6.10.1634045) / FASEB JOURNAL (1992)
  105. GUO, S.W., A MONTE-CARLO METHOD FOR COMBINED SEGREGATION AND LINKAGE ANALYSIS, AMERICAN JOURNAL OF HUMAN GENETICS 51: 1111 (1992). / AMERICAN JOURNAL OF HUMAN GENETICS (1992)
  106. Thompson, E. A., IMA Journal of Mathematics Applied in Medicine and Biology 8: 149 (1991). (10.1093/imammb/8.3.149) / IMA Journal of Mathematics Applied in Medicine and Biology (1991)
  107. GUO, S.W., MONTE-CARLO ESTIMATION OF VARIANCE COMPONENT MODELS FOR LARGE COMPLEX PEDIGREES, IMA JOURNAL OF MATHEMATICS APPLIED IN MEDICINE AND BIOLOGY 8: 171 (1991). (10.1093/imammb/8.3.171) / IMA JOURNAL OF MATHEMATICS APPLIED IN MEDICINE AND BIOLOGY (1991)
  108. HALDANE, JBS, A NEW ESTIMATE OF THE LINKAGE BETWEEN THE GENES FOR COLOUR-BLINDNESS AND HAEMOPHILIA IN MAN, ANNALS OF EUGENICS 14: 10 (1947). (10.1111/j.1469-1809.1947.tb02374.x) / ANNALS OF EUGENICS (1947)
  109. HALEY, C.S., A SIMPLE REGRESSION METHOD FOR MAPPING QUANTITATIVE TRAIT LOCI IN LINE CROSSES USING FLANKING MARKERS, HEREDITY 69: 315 (1992). (10.1038/hdy.1992.131) / HEREDITY (1992)
  110. 10.1126/science.2270482
  111. 10.1126/science.8332896
  112. HASEMAN, J.K., INVESTIGATION OF LINKAGE BETWEEN A QUANTITATIVE TRAIT AND A MARKER LOCUS, BEHAVIOR GENETICS 2: 3 (1972). (10.1007/BF01066731) / BEHAVIOR GENETICS (1972)
  113. HASSTEDT, S. J., COMPUTERS AND BIOMEDICAL RESEARCH 15: 295 (1982). (10.1016/0010-4809(82)90064-7) / COMPUTERS AND BIOMEDICAL RESEARCH (1982)
  114. HASTBACKA, J, THE DIASTROPHIC DYSPLASIA GENE ENCODES A NOVEL SULFATE TRANSPORTER - POSITIONAL CLONING BY FINE-STRUCTURE LINKAGE DISEQUILIBRIUM MAPPING, CELL 78: 1073 (1994). (10.1016/0092-8674(94)90281-X) / CELL (1994)
  115. HASTBACKA, J, LINKAGE DISEQUILIBRIUM MAPPING IN ISOLATED FOUNDER POPULATIONS - DIASTROPHIC DYSPLASIA IN FINLAND, NATURE GENETICS 2: 204 (1992). (10.1038/ng1192-204) / NATURE GENETICS (1992)
  116. HILBERT, P, CHROMOSOMAL MAPPING OF 2 GENETIC-LOCI ASSOCIATED WITH BLOOD-PRESSURE REGULATION IN HEREDITARY HYPERTENSIVE RATS, NATURE 353: 521 (1991). (10.1038/353521a0) / NATURE (1991)
  117. HODGE, S.E., LINKAGE ANALYSIS VERSUS ASSOCIATION ANALYSIS - DISTINGUISHING BETWEEN 2 MODELS THAT EXPLAIN DISEASE-MARKER ASSOCIATIONS, AMERICAN JOURNAL OF HUMAN GENETICS 53: 367 (1993). / AMERICAN JOURNAL OF HUMAN GENETICS (1993)
  118. HODGE, S.E., DO BILINEAL PEDIGREES REPRESENT A PROBLEM FOR LINKAGE ANALYSIS - BASIC PRINCIPLES AND SIMULATION RESULTS FOR SINGLE-GENE DISEASES WITH NO HETEROGENEITY, GENETIC EPIDEMIOLOGY 9: 191 (1992). (10.1002/gepi.1370090306) / GENETIC EPIDEMIOLOGY (1992)
  119. Hodge, S. E., Genetic Epidemiology 11: 329 (1994). (10.1002/gepi.1370110403) / Genetic Epidemiology (1994)
  120. HOLMANS, P, ASYMPTOTIC PROPERTIES OF AFFECTED-SIB-PAIR LINKAGE ANALYSIS, AMERICAN JOURNAL OF HUMAN GENETICS 52: 362 (1993). / AMERICAN JOURNAL OF HUMAN GENETICS (1993)
  121. HUISMAN, THJ, SICKLE-CELL ANEMIA AS A SYNDROME - REVIEW OF DIAGNOSTIC FEATURES, AMERICAN JOURNAL OF HEMATOLOGY 6: 173 (1979). (10.1002/ajh.2830060210) / AMERICAN JOURNAL OF HEMATOLOGY (1979)
  122. HYER, R.N., HIGH-RESOLUTION LINKAGE MAPPING FOR SUSCEPTIBILITY GENES IN HUMAN POLYGENIC DISEASE - INSULIN-DEPENDENT DIABETES-MELLITUS AND CHROMOSOME-11Q, AMERICAN JOURNAL OF HUMAN GENETICS 48: 243 (1991). / AMERICAN JOURNAL OF HUMAN GENETICS (1991)
  123. JACOB, H.J., GENETIC-MAPPING OF A GENE CAUSING HYPERTENSION IN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT, CELL 67: 213 (1991). (10.1016/0092-8674(91)90584-L) / CELL (1991)
  124. JACOB, H.J., GENETIC DISSECTION OF AUTOIMMUNE TYPE-I DIABETES IN THE BB RAT, NATURE GENETICS 2: 56 (1992). (10.1038/ng0992-56) / NATURE GENETICS (1992)
  125. JANSEN, R.C., INTERVAL MAPPING OF MULTIPLE QUANTITATIVE TRAIT LOCI, GENETICS 135: 205 (1993). (10.1093/genetics/135.1.205) / GENETICS (1993)
  126. JANSEN, R.C., HIGH-RESOLUTION OF QUANTITATIVE TRAITS INTO MULTIPLE LOCI VIA INTERVAL MAPPING, GENETICS 136: 1447 (1994). (10.1093/genetics/136.4.1447) / GENETICS (1994)
  127. JANSEN, R.C., A GENERAL MIXTURE MODEL FOR MAPPING QUANTITATIVE TRAIT LOCI BY USING MOLECULAR MARKERS, THEORETICAL AND APPLIED GENETICS 85: 252 (1992). / THEORETICAL AND APPLIED GENETICS (1992)
  128. JASPERS, NGJ, GENETIC-HETEROGENEITY IN ATAXIA-TELANGIECTASIA STUDIED BY CELL-FUSION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 2641 (1982). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1982)
  129. JEUNEMAITRE, X, MOLECULAR-BASIS OF HUMAN HYPERTENSION - ROLE OF ANGIOTENSINOGEN, CELL 71: 169 (1992). (10.1016/0092-8674(92)90275-H) / CELL (1992)
  130. 10.1016/0092-8674(81)90022-2
  131. JULIER, C, INSULIN-IGF2 REGION ON CHROMOSOME-11P ENCODES A GENE IMPLICATED IN HLA-DR4-DEPENDENT DIABETES SUSCEPTIBILITY, NATURE 354: 155 (1991). (10.1038/354155a0) / NATURE (1991)
  132. 10.1126/science.8202715
  133. 10.1038/342238a0
  134. KENNEDY, J.L., EVIDENCE AGAINST LINKAGE OF SCHIZOPHRENIA TO MARKERS ON CHROMOSOME-5 IN A NORTHERN SWEDISH PEDIGREE, NATURE 336: 167 (1988). (10.1038/336167a0) / NATURE (1988)
  135. 10.1126/science.2570460
  136. Khoury M. J. Fundamentals of Genetic Epidemiology (1993). (10.1093/oso/9780195052886.001.0001)
  137. KIDD, K.K., POWER AND SAMPLE-SIZE IN LINKAGE STUDIES, CYTOGENETICS AND CELL GENETICS 37: 510 (1984). / CYTOGENETICS AND CELL GENETICS (1984)
  138. KING, M.C., GENETIC EPIDEMIOLOGY, ANNUAL REVIEW OF PUBLIC HEALTH 5: 1 (1984). (10.1146/annurev.pu.05.050184.000245) / ANNUAL REVIEW OF PUBLIC HEALTH (1984)
  139. 10.1126/science.1651562
  140. KNAPP, M, THE HAPLOTYPE-RELATIVE-RISK (HRR) METHOD FOR ANALYSIS OF ASSOCIATION IN NUCLEAR FAMILIES, AMERICAN JOURNAL OF HUMAN GENETICS 52: 1085 (1993). / AMERICAN JOURNAL OF HUMAN GENETICS (1993)
  141. KNAPP, M, LINKAGE ANALYSIS IN NUCLEAR FAMILIES .1. OPTIMALITY CRITERIA FOR AFFECTED SIB-PAIR TESTS, HUMAN HEREDITY 44: 37 (1994). (10.1159/000154187) / HUMAN HEREDITY (1994)
  142. KNOTT, S.A., MAXIMUM-LIKELIHOOD MAPPING OF QUANTITATIVE TRAIT LOCI USING FULL-SIB FAMILIES, GENETICS 132: 1211 (1992). (10.1093/genetics/132.4.1211) / GENETICS (1992)
  143. KONG, A, IMPORTANCE SAMPLING .1. COMPUTING MULTIMODEL-P VALUES IN LINKAGE ANALYSIS, AMERICAN JOURNAL OF HUMAN GENETICS 51: 1413 (1992). / AMERICAN JOURNAL OF HUMAN GENETICS (1992)
  144. KONG, A, SEQUENTIAL IMPUTATION AND MULTIPOINT LINKAGE ANALYSIS, GENETIC EPIDEMIOLOGY 10: 483 (1993). (10.1002/gepi.1370100626) / GENETIC EPIDEMIOLOGY (1993)
  145. KRUGLYAK L unpublished data.
  146. KUMARSINGH, R, EVIDENCE FOR FURTHER GENETIC-HETEROGENEITY IN AUTOSOMAL DOMINANT RETINITIS-PIGMENTOSA, GENOMICS 15: 212 (1993). (10.1006/geno.1993.1038) / GENOMICS (1993)
  147. Lander, E. S., Cold Spring Harbor Symposia on Quantitative Biology 51: 49 (1986). (10.1101/SQB.1986.051.01.007) / Cold Spring Harbor Symposia on Quantitative Biology (1986)
  148. 10.1093/genetics/121.1.185
  149. LANDER, E.S., STRATEGIES FOR STUDYING HETEROGENEOUS GENETIC-TRAITS IN HUMANS BY USING A LINKAGE MAP OF RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISMS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 7353 (1986). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1986)
  150. 10.1073/pnas.84.8.2363
  151. LANGE, K, ACCURATE AND SUPERACCURATE GENE-MAPPING, AMERICAN JOURNAL OF HUMAN GENETICS 37: 853 (1985). / AMERICAN JOURNAL OF HUMAN GENETICS (1985)
  152. LANGE, K, THE AFFECTED SIB-PAIR METHOD USING IDENTITY BY STATE RELATIONS, AMERICAN JOURNAL OF HUMAN GENETICS 39: 148 (1986). / AMERICAN JOURNAL OF HUMAN GENETICS (1986)
  153. LANGE, K, EXTENSIONS TO PEDIGREE ANALYSIS .1. LIKELIHOOD CALCULATIONS FOR SIMPLE AND COMPLEX PEDIGREES, HUMAN HEREDITY 25: 95 (1975). (10.1159/000152714) / HUMAN HEREDITY (1975)
  154. 10.1073/pnas.81.11.3443
  155. 10.1016/0092-8674(93)90330-S
  156. LI, C.C., A GENETIC MODEL FOR EMERGENESIS - IN MEMORY OF SNYDER,LAURENCE,H, 1901-86, AMERICAN JOURNAL OF HUMAN GENETICS 41: 517 (1987). / AMERICAN JOURNAL OF HUMAN GENETICS (1987)
  157. LIU, B, HMSH2 MUTATIONS IN HEREDITARY NONPOLYPOSIS COLORECTAL-CANCER KINDREDS, CANCER RESEARCH 54: 4590 (1994). / CANCER RESEARCH (1994)
  158. LUO, Z.W., INTERVAL MAPPING OF QUANTITATIVE TRAIT LOCI IN AN F2 POPULATION, HEREDITY 69: 236 (1992). (10.1038/hdy.1992.121) / HEREDITY (1992)
  159. MACLEAN, C. J., COMPUTERS AND BIOMEDICAL RESEARCH 17: 471 (1984). (10.1016/0010-4809(84)90013-2) / COMPUTERS AND BIOMEDICAL RESEARCH (1984)
  160. MAJUMDER, P.P., A GENETIC MODEL FOR VITILIGO, AMERICAN JOURNAL OF HUMAN GENETICS 43: 119 (1988). / AMERICAN JOURNAL OF HUMAN GENETICS (1988)
  161. MAJUMDER, P.P., COMPARISON OF ASCERTAINMENT-BIAS CORRECTION SCHEMES FOR PEDIGREES ASCERTAINED THROUGH MULTIPLE PROBANDS, STATISTICS IN MEDICINE 4: 163 (1985). (10.1002/sim.4780040207) / STATISTICS IN MEDICINE (1985)
  162. MARENBERG, M.E., GENETIC SUSCEPTIBILITY TO DEATH FROM CORONARY HEART-DISEASE IN A STUDY OF TWINS, NEW ENGLAND JOURNAL OF MEDICINE 330: 1041 (1994). (10.1056/NEJM199404143301503) / NEW ENGLAND JOURNAL OF MEDICINE (1994)
  163. 10.1126/science.8178175
  164. McKusick V. A. Mendelian Inheritance in Man (1992).
  165. MERIKANGAS, K.R., LINKAGE STUDIES OF BIPOLAR DISORDER - METHODOLOGIC AND ANALYTIC ISSUES - REPORT OF MACARTHUR-FOUNDATION WORKSHOP ON LINKAGE AND CLINICAL-FEATURES IN AFFECTIVE-DISORDERS, ARCHIVES OF GENERAL PSYCHIATRY 46: 1137 (1989). (10.1001/archpsyc.1989.01810120079012) / ARCHIVES OF GENERAL PSYCHIATRY (1989)
  166. MOEN, CJA, SCC-1, A NOVEL COLON CANCER SUSCEPTIBILITY GENE IN THE MOUSE - LINKAGE TO CD44 (LY-24, PGP-1) ON CHROMOSOME-2, ONCOGENE 7: 563 (1992). / ONCOGENE (1992)
  167. MORRISON, N.A., PREDICTION OF BONE-DENSITY FROM VITAMIN-D RECEPTOR ALLELES, NATURE 367: 284 (1994). (10.1038/367284a0) / NATURE (1994)
  168. MORTON, N.E., THE DETECTION AND ESTIMATION OF LINKAGE BETWEEN THE GENES FOR ELLIPTOCYTOSIS AND THE RH-BLOOD TYPE, AMERICAN JOURNAL OF HUMAN GENETICS 8: 80 (1956). / AMERICAN JOURNAL OF HUMAN GENETICS (1956)
  169. MORTON, N.E., GENETIC TESTS UNDER INCOMPLETE ASCERTAINMENT, AMERICAN JOURNAL OF HUMAN GENETICS 11: 1 (1959). / AMERICAN JOURNAL OF HUMAN GENETICS (1959)
  170. MORTON, N.E., ANALYSIS OF FAMILY RESEMBLANCE .3. COMPLEX SEGREGATION OF QUANTITATIVE TRAITS, AMERICAN JOURNAL OF HUMAN GENETICS 26: 489 (1974). / AMERICAN JOURNAL OF HUMAN GENETICS (1974)
  171. MORTON, N.E., HETEROZYGOUS EXPRESSION OF INSULIN-DEPENDENT DIABETES-MELLITUS (IDDM) DETERMINANTS IN THE HLA SYSTEM, AMERICAN JOURNAL OF HUMAN GENETICS 35: 201 (1983). / AMERICAN JOURNAL OF HUMAN GENETICS (1983)
  172. MOSER A COMMUNICATION.
  173. Nath S. K. American Journal of Human Genetics in press.
  174. Neale M. C. Methodology for Genetic Studies of Twins and Families (1992). (10.1007/978-94-015-8018-2)
  175. NEWMAN, B, INHERITANCE OF HUMAN-BREAST CANCER - EVIDENCE FOR AUTOSOMAL DOMINANT TRANSMISSION IN HIGH-RISK FAMILIES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 3044 (1988). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1988)
  176. Noreen E. W. Computer Intensive Methods for Testing Hypotheses (1989).
  177. OLSON, J.M., LINKAGE BETWEEN QUANTITATIVE TRAIT AND MARKER LOCI - METHODS USING ALL RELATIVE PAIRS, GENETIC EPIDEMIOLOGY 10: 87 (1993). (10.1002/gepi.1370100202) / GENETIC EPIDEMIOLOGY (1993)
  178. OTT, J, ESTIMATION OF RECOMBINATION FRACTION IN HUMAN PEDIGREES - EFFICIENT COMPUTATION OF LIKELIHOOD FOR HUMAN LINKAGE STUDIES, AMERICAN JOURNAL OF HUMAN GENETICS 26: 588 (1974). / AMERICAN JOURNAL OF HUMAN GENETICS (1974)
  179. OTT, J, COMPUTER-PROGRAM FOR LINKAGE ANALYSIS OF GENERAL HUMAN PEDIGREES, AMERICAN JOURNAL OF HUMAN GENETICS 28: 528 (1976). / AMERICAN JOURNAL OF HUMAN GENETICS (1976)
  180. OTT, J, MAXIMUM LIKELIHOOD ESTIMATION BY COUNTING METHODS UNDER POLYGENIC AND MIXED MODELS IN HUMAN PEDIGREES, AMERICAN JOURNAL OF HUMAN GENETICS 31: 161 (1979). / AMERICAN JOURNAL OF HUMAN GENETICS (1979)
  181. OTT, J, CUTTING A GORDIAN KNOT IN THE LINKAGE ANALYSIS OF COMPLEX HUMAN TRAITS, AMERICAN JOURNAL OF HUMAN GENETICS 46: 219 (1990). / AMERICAN JOURNAL OF HUMAN GENETICS (1990)
  182. Ott, J., Analysis of Human Genetic Linkage: 65 (1991). / Analysis of Human Genetic Linkage (1991)
  183. OTT, J, LINKAGE ANALYSIS WITH MISCLASSIFICATION AT ONE LOCUS, CLINICAL GENETICS 12: 119 (1977). (10.1111/j.1399-0004.1977.tb00913.x) / CLINICAL GENETICS (1977)
  184. OTT, J, STATISTICAL PROPERTIES OF THE HAPLOTYPE RELATIVE RISK, GENETIC EPIDEMIOLOGY 6: 127 (1989). (10.1002/gepi.1370060124) / GENETIC EPIDEMIOLOGY (1989)
  185. OTT, J, COMPUTER-SIMULATION METHODS IN HUMAN LINKAGE ANALYSIS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 4175 (1989). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1989)
  186. OWERBACH, D, LINKAGE OF THE VNTR INSULIN-GENE AND TYPE-I DIABETES-MELLITUS - INCREASED GENE SHARING IN AFFECTED SIBLING PAIRS, AMERICAN JOURNAL OF HUMAN GENETICS 54: 909 (1994). / AMERICAN JOURNAL OF HUMAN GENETICS (1994)
  187. 10.1126/science.8128251
  188. 10.1001/archpsyc.1991.01810310073013
  189. 10.1038/335721a0
  190. PATO, C.N., REVIEW OF THE PUTATIVE ASSOCIATION OF DOPAMINE D2 RECEPTOR AND ALCOHOLISM - A METAANALYSIS, AMERICAN JOURNAL OF MEDICAL GENETICS 48: 78 (1993). (10.1002/ajmg.1320480204) / AMERICAN JOURNAL OF MEDICAL GENETICS (1993)
  191. PENROSE, L.S., ACTA GENET 4: 257 (1953). / ACTA GENET (1953)
  192. PERICAKVANCE, M.A., LINKAGE STUDIES IN FAMILIAL ALZHEIMER-DISEASE - EVIDENCE FOR CHROMOSOME-19 LINKAGE, AMERICAN JOURNAL OF HUMAN GENETICS 48: 1034 (1991). / AMERICAN JOURNAL OF HUMAN GENETICS (1991)
  193. PETES, T.D., SIMPLE MENDELIAN INHERITANCE OF REITERATED RIBOSOMAL DNA OF YEAST, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 5091 (1977). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1977)
  194. PLOMIN, R, DNA MARKERS ASSOCIATED WITH HIGH VERSUS LOW IQ - THE IQ QUANTITATIVE TRAIT LOCI (QTL) PROJECT, BEHAVIOR GENETICS 24: 107 (1994). (10.1007/BF01067815) / BEHAVIOR GENETICS (1994)
  195. Provine W. B. The Origins of Theoretical Population Genetics (1971). (10.2307/2412271)
  196. PUFFENBERGER, E.G., IDENTITY-BY-DESCENT AND ASSOCIATION MAPPING OF A RECESSIVE GENE FOR HIRSCHSPRUNG DISEASE ON HUMAN-CHROMOSOME 13Q22, HUMAN MOLECULAR GENETICS 3: 1217 (1994). (10.1093/hmg/3.8.1217) / HUMAN MOLECULAR GENETICS (1994)
  197. PULVER, A.E., SEQUENTIAL STRATEGY TO IDENTIFY A SUSCEPTIBILITY GENE FOR SCHIZOPHRENIA - REPORT OF POTENTIAL LINKAGE ON CHROMOSOME 22Q12-Q13.1 .1., AMERICAN JOURNAL OF MEDICAL GENETICS 54: 36 (1994). (10.1002/ajmg.1320540108) / AMERICAN JOURNAL OF MEDICAL GENETICS (1994)
  198. REBAI, A, APPROXIMATE THRESHOLDS OF INTERVAL MAPPING TESTS FOR QTL DETECTION, GENETICS 138: 235 (1994). (10.1093/genetics/138.1.235) / GENETICS (1994)
  199. REDMAN, J. B., JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 269: 1960 (1993). (10.1001/jama.1993.03500150072029) / JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (1993)
  200. REEDERS, S.T., A STUDY OF GENETIC-LINKAGE HETEROGENEITY IN ADULT POLYCYSTIC KIDNEY-DISEASE, HUMAN GENETICS 76: 348 (1987). (10.1007/BF00272443) / HUMAN GENETICS (1987)
  201. RICH, S.S., SHARED GENETIC SUSCEPTIBILITY OF TYPE-1 (INSULIN-DEPENDENT) AND TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS - CONTRIBUTIONS OF HLA AND HAPTOGLOBIN, DIABETOLOGIA 34: 350 (1991). (10.1007/BF00405008) / DIABETOLOGIA (1991)
  202. RISCH, N, LINKAGE STRATEGIES FOR GENETICALLY COMPLEX TRAITS .1. MULTILOCUS MODELS, AMERICAN JOURNAL OF HUMAN GENETICS 46: 222 (1990). / AMERICAN JOURNAL OF HUMAN GENETICS (1990)
  203. RISCH, N, LINKAGE STRATEGIES FOR GENETICALLY COMPLEX TRAITS .2. THE POWER OF AFFECTED RELATIVE PAIRS, AMERICAN JOURNAL OF HUMAN GENETICS 46: 229 (1990). / AMERICAN JOURNAL OF HUMAN GENETICS (1990)
  204. RISCH, N, LINKAGE STRATEGIES FOR GENETICALLY COMPLEX TRAITS .3. THE EFFECT OF MARKER POLYMORPHISM ON ANALYSIS OF AFFECTED RELATIVE PAIRS, AMERICAN JOURNAL OF HUMAN GENETICS 46: 242 (1990). / AMERICAN JOURNAL OF HUMAN GENETICS (1990)
  205. RISCH, N, STATISTICAL EVALUATION OF MULTIPLE-LOCUS LINKAGE DATA IN EXPERIMENTAL SPECIES AND ITS RELEVANCE TO HUMAN STUDIES - APPLICATION TO NONOBESE DIABETIC (NOD) MOUSE AND HUMAN INSULIN-DEPENDENT DIABETES-MELLITUS (IDDM), AMERICAN JOURNAL OF HUMAN GENETICS 53: 702 (1993). / AMERICAN JOURNAL OF HUMAN GENETICS (1993)
  206. Risch N. AM J HUM GENET S 53 (1993).
  207. 10.1126/science.1871601
  208. ROMEO, G, A 2ND GENETIC-LOCUS FOR AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY-DISEASE, LANCET 2: 8 (1988). / LANCET (1988)
  209. Ryder L. P. HLA and Disease Registry Third Report (1979).
  210. SCHACHTER, F, GENETIC ASSOCIATIONS WITH HUMAN LONGEVITY AT THE APOE AND ACE LOCI, NATURE GENETICS 6: 29 (1994). (10.1038/ng0194-29) / NATURE GENETICS (1994)
  211. 10.1126/science.1411576
  212. SCHORK, N, TESTING SEPARATE FAMILIES OF SEGREGATION HYPOTHESES - BOOTSTRAP METHODS, AMERICAN JOURNAL OF HUMAN GENETICS 45: 803 (1989). / AMERICAN JOURNAL OF HUMAN GENETICS (1989)
  213. SCHORK, N, EFFICIENT COMPUTATION OF PATTERNED COVARIANCE-MATRIX MIXED MODELS IN QUANTITATIVE SEGREGATION ANALYSIS, GENETIC EPIDEMIOLOGY 8: 29 (1991). (10.1002/gepi.1370080104) / GENETIC EPIDEMIOLOGY (1991)
  214. SCHORK, N.J., 2-TRAIT-LOCUS LINKAGE ANALYSIS - A POWERFUL STRATEGY FOR MAPPING COMPLEX GENETIC-TRAITS, AMERICAN JOURNAL OF HUMAN GENETICS 53: 1127 (1993). / AMERICAN JOURNAL OF HUMAN GENETICS (1993)
  215. SCHORK, N.J., PEDIGREE MODELS FOR COMPLEX HUMAN TRAITS INVOLVING THE MITOCHONDRIAL GENOME, AMERICAN JOURNAL OF HUMAN GENETICS 53: 1320 (1993). / AMERICAN JOURNAL OF HUMAN GENETICS (1993)
  216. Schork N. J. Computing Science and Statistics: Proceedings of the 23rd Symposium on the Interface (1994).
  217. Schork N. J. Exploring the Limits of the Bootstrap (1991).
  218. SCHORK, N.J., EXTENDED PEDIGREE PATTERNED COVARIANCE-MATRIX MIXED MODELS FOR QUANTITATIVE PHENOTYPE ANALYSIS, GENETIC EPIDEMIOLOGY 9: 73 (1992). (10.1002/gepi.1370090202) / GENETIC EPIDEMIOLOGY (1992)
  219. SCHORK, N.J., DETECTION OF GENETIC-HETEROGENEITY FOR COMPLEX QUANTITATIVE PHENOTYPES, GENETIC EPIDEMIOLOGY 9: 207 (1992). (10.1002/gepi.1370090307) / GENETIC EPIDEMIOLOGY (1992)
  220. SCHORK N.J. unpublished data.
  221. SCHUNKERT, H, ASSOCIATION BETWEEN A DELETION POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING-ENZYME GENE AND LEFT-VENTRICULAR HYPERTROPHY, NEW ENGLAND JOURNAL OF MEDICINE 330: 1634 (1994). (10.1056/NEJM199406093302302) / NEW ENGLAND JOURNAL OF MEDICINE (1994)
  222. SCHWAB, S, AMERICAN JOURNAL OF HUMAN GENETICS 49: 203 (1991). / AMERICAN JOURNAL OF HUMAN GENETICS (1991)
  223. SELBY, J. V., JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 265: 2079 (1991). (10.1001/jama.1991.03460160057029) / JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (1991)
  224. SERIKAWA, T, RAT GENE-MAPPING USING PCR-ANALYZED MICROSATELLITES, GENETICS 131: 701 (1992). (10.1093/genetics/131.3.701) / GENETICS (1992)
  225. SHERRINGTON, R, LOCALIZATION OF A SUSCEPTIBILITY LOCUS FOR SCHIZOPHRENIA ON CHROMOSOME-5, NATURE 336: 164 (1988). (10.1038/336164a0) / NATURE (1988)
  226. SHIMOZAWA, N, A HUMAN GENE RESPONSIBLE FOR ZELLWEGER SYNDROME THAT AFFECTS PEROXISOME ASSEMBLY, SCIENCE 255: 1132 (1992). (10.1126/science.1546315) / SCIENCE (1992)
  227. SINGER, C, HAW RIVER SYNDROME OR DENTATO-RUBRO-PALLIDO-LUYSIAN ATROPHY, ARCHIVES OF NEUROLOGY 49: 13 (1992). / ARCHIVES OF NEUROLOGY (1992)
  228. SOBEL, E, ATAXIA-TELANGIECTASIA - LINKAGE EVIDENCE FOR GENETIC-HETEROGENEITY, AMERICAN JOURNAL OF HUMAN GENETICS 50: 1343 (1992). / AMERICAN JOURNAL OF HUMAN GENETICS (1992)
  229. SPENCE, M.A., METHODOLOGICAL ISSUES IN LINKAGE ANALYSES FOR PSYCHIATRIC-DISORDERS - SECULAR TRENDS, ASSORTATIVE MATING, BILINEAL PEDIGREES - REPORT OF THE MACARTHUR-FOUNDATION NETWORK-I TASK-FORCE ON METHODOLOGICAL ISSUES, HUMAN HEREDITY 43: 166 (1993). (10.1159/000154173) / HUMAN HEREDITY (1993)
  230. SPIELMAN, R.S., TRANSMISSION TEST FOR LINKAGE DISEQUILIBRIUM - THE INSULIN GENE REGION AND INSULIN-DEPENDENT DIABETES-MELLITUS (IDDM), AMERICAN JOURNAL OF HUMAN GENETICS 52: 506 (1993). / AMERICAN JOURNAL OF HUMAN GENETICS (1993)
  231. SPIERER, P, MOLECULAR MAPPING OF GENETIC AND CHROMOMERIC UNITS IN DROSOPHILA-MELANOGASTER, JOURNAL OF MOLECULAR BIOLOGY 168: 35 (1983). (10.1016/S0022-2836(83)80321-0) / JOURNAL OF MOLECULAR BIOLOGY (1983)
  232. STEINBERG, M.H., CLINICAL DIVERSITY OF SICKLE-CELL-ANEMIA - GENETIC AND CELLULAR MODULATION OF DISEASE SEVERITY, AMERICAN JOURNAL OF HEMATOLOGY 14: 405 (1983). (10.1002/ajh.2830140412) / AMERICAN JOURNAL OF HEMATOLOGY (1983)
  233. STGEORGEHYSLOP, P.H., GENETIC-LINKAGE STUDIES SUGGEST THAT ALZHEIMERS-DISEASE IS NOT A SINGLE HOMOGENEOUS DISORDER, NATURE 347: 194 (1990). (10.1038/347194a0) / NATURE (1990)
  234. STURTEVANT, A.H., The linear arrangement of six sex-linked factors in Drosophila, as shown by their mode of association, JOURNAL OF EXPERIMENTAL ZOOLOGY 14: 43 (1913). (10.1002/jez.1400140104) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1913)
  235. SUAREZ, B.K., GENERALIZED SIB PAIR IBD DISTRIBUTION - ITS USE IN DETECTION OF LINKAGE, ANNALS OF HUMAN GENETICS 42: 87 (1978). (10.1111/j.1469-1809.1978.tb00933.x) / ANNALS OF HUMAN GENETICS (1978)
  236. 10.1006/geno.1994.1005
  237. TAGER, J.M., PROG CLIN BIOL RES 321: 545 (1990). / PROG CLIN BIOL RES (1990)
  238. TANKSLEY, S.D., MAPPING POLYGENES, ANNUAL REVIEW OF GENETICS 27: 205 (1993). (10.1146/annurev.ge.27.120193.001225) / ANNUAL REVIEW OF GENETICS (1993)
  239. TERWILLIGER, J.D., A MULTISAMPLE BOOTSTRAP APPROACH TO THE ESTIMATION OF MAXIMIZED-OVER-MODELS LOD SCORE DISTRIBUTIONS, CYTOGENETICS AND CELL GENETICS 59: 142 (1992). (10.1159/000133228) / CYTOGENETICS AND CELL GENETICS (1992)
  240. TERWILLIGER, J.D., A HAPLOTYPE-BASED HAPLOTYPE RELATIVE RISK APPROACH TO DETECTING ALLELIC ASSOCIATIONS, HUMAN HEREDITY 42: 337 (1992). (10.1159/000154096) / HUMAN HEREDITY (1992)
  241. THEIN, S.L., DETECTION OF A MAJOR GENE FOR HETEROCELLULAR HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN AFTER ACCOUNTING FOR GENETIC MODIFIERS, AMERICAN JOURNAL OF HUMAN GENETICS 54: 214 (1994). / AMERICAN JOURNAL OF HUMAN GENETICS (1994)
  242. THOMAS, D.C., FITTING GENETIC DATA USING GIBBS SAMPLING - AN APPLICATION TO NEVUS COUNTS IN 38 UTAH KINDREDS, CYTOGENETICS AND CELL GENETICS 59: 228 (1992). (10.1159/000133255) / CYTOGENETICS AND CELL GENETICS (1992)
  243. THOMPSON, E.A., OPTIMAL SAMPLING FOR PEDIGREE ANALYSIS - RELATIVES OF AFFECTED PROBANDS, AMERICAN JOURNAL OF HUMAN GENETICS 33: 968 (1981). / AMERICAN JOURNAL OF HUMAN GENETICS (1981)
  244. THOMPSON, E.A., OPTIMAL SAMPLING FOR PEDIGREE ANALYSIS - SEQUENTIAL SCHEMES FOR SIBSHIPS, BIOMETRICS 37: 313 (1981). (10.2307/2530420) / BIOMETRICS (1981)
  245. THOMPSON, E.A., GENETIC EPIDEMIOLOGY - A REVIEW OF THE STATISTICAL BASIS, STATISTICS IN MEDICINE 5: 291 (1986). (10.1002/sim.4780050402) / STATISTICS IN MEDICINE (1986)
  246. THOMPSON, E.A., OPTIMAL SAMPLING FOR PEDIGREE ANALYSIS - PARAMETER-ESTIMATION AND GENOTYPIC UNCERTAINTY, THEORETICAL POPULATION BIOLOGY 24: 39 (1983). (10.1016/0040-5809(83)90045-X) / THEORETICAL POPULATION BIOLOGY (1983)
  247. THOMPSON, G, GENET EPIDEMIOL 6: 43 (1989). (10.1002/gepi.1370060111) / GENET EPIDEMIOL (1989)
  248. TIENARI, P.J., 2-LOCUS LINKAGE ANALYSIS IN MULTIPLE-SCLEROSIS (MS), GENOMICS 19: 320 (1994). (10.1006/geno.1994.1064) / GENOMICS (1994)
  249. Titterington D. M. Statistical Analysis of Finite Mixture Distributions (1985).
  250. 10.1126/science.8178173
  251. TURCO, A, LINKAGE ANALYSIS FOR THE DIAGNOSIS OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY-DISEASE, AND FOR THE DETERMINATION OF GENETIC-HETEROGENEITY IN ITALIAN FAMILIES, CLINICAL GENETICS 40: 287 (1991). (10.1111/j.1399-0004.1991.tb03098.x) / CLINICAL GENETICS (1991)
  252. WALLACE, D.C., DISEASES OF THE MITOCHONDRIAL-DNA, ANNUAL REVIEW OF BIOCHEMISTRY 61: 1175 (1992). (10.1146/annurev.bi.61.070192.005523) / ANNUAL REVIEW OF BIOCHEMISTRY (1992)
  253. Ward, R., Hypertension: Pathophysiology, Diagnosis, and Management: 81 (1990). / Hypertension: Pathophysiology, Diagnosis, and Management (1990)
  254. WEEKS, D.E., THE AFFECTED-PEDIGREE-MEMBER METHOD OF LINKAGE ANALYSIS, AMERICAN JOURNAL OF HUMAN GENETICS 42: 315 (1988). / AMERICAN JOURNAL OF HUMAN GENETICS (1988)
  255. WEEKS, D.E., A MULTILOCUS EXTENSION OF THE AFFECTED-PEDIGREE-MEMBER METHOD OF LINKAGE ANALYSIS, AMERICAN JOURNAL OF HUMAN GENETICS 50: 859 (1992). / AMERICAN JOURNAL OF HUMAN GENETICS (1992)
  256. WEEKS, D.E., AM J HUM GENET 47: A204 (1990). / AM J HUM GENET (1990)
  257. WEEKS, D.E., MEASURING THE INFLATION OF THE LOD SCORE DUE TO ITS MAXIMIZATION OVER MODEL PARAMETER VALUES IN HUMAN LINKAGE ANALYSIS, GENETIC EPIDEMIOLOGY 7: 237 (1990). (10.1002/gepi.1370070402) / GENETIC EPIDEMIOLOGY (1990)
  258. Weinberg, W., Archiv fur Rassen- und Gesellschaftsbiologie 9: 165 (1912). / Archiv fur Rassen- und Gesellschaftsbiologie (1912)
  259. Weiss K. M. Genetic Variation and Human Disease (1993). (10.1017/CBO9781139167987)
  260. Weiss K. M. Genetic Variation and Human Disease (1993). (10.1017/CBO9781139167987)
  261. WEITKAMP, L.R., DEPRESSIVE-DISORDERS AND HLA - A GENE ON CHROMOSOME-6 THAT CAN AFFECT BEHAVIOR, NEW ENGLAND JOURNAL OF MEDICINE 305: 1301 (1981). (10.1056/NEJM198111263052201) / NEW ENGLAND JOURNAL OF MEDICINE (1981)
  262. WHITTEMORE, A.S., A CLASS OF TESTS FOR LINKAGE USING AFFECTED PEDIGREE MEMBERS, BIOMETRICS 50: 118 (1994). (10.2307/2533202) / BIOMETRICS (1994)
  263. WILLIAMS, R.R., FAMILIAL DYSLIPIDEMIC HYPERTENSION AND OTHER MULTIPLE METABOLIC SYNDROMES, ANNALS OF MEDICINE 24: 469 (1992). (10.3109/07853899209166998) / ANNALS OF MEDICINE (1992)
  264. WILLIAMS, R.R., POPULATION-BASED FREQUENCY OF DYSLIPIDEMIA SYNDROMES IN CORONARY-PRONE FAMILIES IN UTAH, ARCHIVES OF INTERNAL MEDICINE 150: 582 (1990). (10.1001/archinte.1990.00390150076015) / ARCHIVES OF INTERNAL MEDICINE (1990)
  265. WILLIAMS, W.R., GENET EPIDEMIOL 1: 7 (1984). (10.1002/gepi.1370010104) / GENET EPIDEMIOL (1984)
  266. WILLIAMSON, J.A., ON THE ASYMPTOTIC-BEHAVIOR OF THE ESTIMATE OF THE RECOMBINATION FRACTION UNDER THE NULL HYPOTHESIS OF NO LINKAGE WHEN THE MODEL IS MISSPECIFIED, GENETIC EPIDEMIOLOGY 7: 309 (1990). (10.1002/gepi.1370070502) / GENETIC EPIDEMIOLOGY (1990)
  267. Wright, S., Evolution and the Genetics of Populations: Genetic and Biometric Foundations: 373 (1968). / Evolution and the Genetics of Populations: Genetic and Biometric Foundations (1968)
  268. YOUNG, M.R., CORRECTING FOR SINGLE ASCERTAINMENT BY TRUNCATION FOR A QUANTITATIVE TRAIT, AMERICAN JOURNAL OF HUMAN GENETICS 43: 705 (1988). / AMERICAN JOURNAL OF HUMAN GENETICS (1988)
  269. YU, C.E., THE APOLIPOPROTEIN E/CI/CII GENE-CLUSTER AND LATE-ONSET ALZHEIMER-DISEASE, AMERICAN JOURNAL OF HUMAN GENETICS 54: 631 (1994). / AMERICAN JOURNAL OF HUMAN GENETICS (1994)
  270. ZENG, Z.B., PRECISION MAPPING OF QUANTITATIVE TRAIT LOCI, GENETICS 136: 1457 (1994). (10.1093/genetics/136.4.1457) / GENETICS (1994)
  271. ZENG, Z.B., THEORETICAL BASIS FOR SEPARATION OF MULTIPLE LINKED GENE EFFECTS IN MAPPING QUANTITATIVE TRAIT LOCI, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 10972 (1993). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1993)
Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 8:01 p.m.)
Deposited 7 months, 3 weeks ago (Jan. 11, 2025, 3:44 a.m.)
Indexed 1 day, 17 hours ago (Sept. 3, 2025, 6:38 a.m.)
Issued 30 years, 11 months ago (Sept. 30, 1994)
Published 30 years, 11 months ago (Sept. 30, 1994)
Published Print 30 years, 11 months ago (Sept. 30, 1994)
Funders 0

None

@article{Lander_1994, title={Genetic Dissection of Complex Traits}, volume={265}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8091226}, DOI={10.1126/science.8091226}, number={5181}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Lander, Eric S. and Schork, Nicholas J.}, year={1994}, month=sep, pages={2037–2048} }