DOI: 10.1126/science.8079170. Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

10.1126/science.8079170

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The transcription factor PU.1 is a hematopoietic-specific member of theetsfamily. Mice carrying a mutation in thePU.1locus were generated by gene targeting. Homozygous mutant embryos died at a late gestational stage. Mutant embryos produced normal numbers of megakaryocytes and erythroid progenitors, but some showed an impairment of erythroblast maturation. An invariant consequence of the mutation was a multilineage defect in the generation of progenitors for B and T lymphocytes, monocytes, and granulocytes. Thus, the developmental programs of lymphoid and myeloid lineages require a common genetic function likely acting at the level of a multipotential progenitor.

Bibliography

Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994). Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages. Science, 265(5178), 1573â1577.

Authors 4

Edward W. Scott (first)
M. Celeste Simon (additional)
John Anastasi (additional)
Harinder Singh (additional)

References 40 Referenced 1,269

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Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 8:01 p.m.)
Deposited	7 months, 3 weeks ago (Jan. 11, 2025, 3:42 a.m.)
Indexed	2 days, 15 hours ago (Sept. 3, 2025, 6:19 a.m.)
Issued	30 years, 11 months ago (Sept. 9, 1994)
Published	30 years, 11 months ago (Sept. 9, 1994)
Published Print	30 years, 11 months ago (Sept. 9, 1994)

Funders 0

None

BibTeX

@article{Scott_1994, title={Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages}, volume={265}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8079170}, DOI={10.1126/science.8079170}, number={5178}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Scott, Edward W. and Simon, M. Celeste and Anastasi, John and Singh, Harinder}, year={1994}, month=sep, pages={1573–1577} }

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