DOI: 10.1126/science.8066462. cDNA Cloning and Interferon γ Down-Regulation of Proteasomal Aubunits X and Y

cDNA Cloning and Interferon γ Down-Regulation of Proteasomal Aubunits X and Y

10.1126/science.8066462

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Proteasomes are the proteolytic complex responsible for major histocompatibility complex (MHC) class I-restricted antigen presentation. Interferon γ treatment increases expression of MHC-encoded LMP2 and LMP7 subunits of the proteasome and decreases expression of two proteasome subunits, named X and Y, which alters the proteolytic specificity of proteasomes. Molecular cloning of complementary DNAs encoding X and Y showed that their proteins are proteasomal subunits with high amino acid similarity to LMP7 and LMP2, respectively. Thus, interferon γ may induce subunit replacements of X and Y by LMP7 and LMP2, respectively, producing proteasomes perhaps more appropriate for the immunological processing of endogenous antigens.

Bibliography

Akiyama, K., Yokota, K., Kagawa, S., Shimbara, N., Tamura, T., Akioka, H., Nothwang, H. G., Noda, C., Tanaka, K., & Ichihara, A. (1994). cDNA Cloning and Interferon Î³ Down-Regulation of Proteasomal Aubunits X and Y. Science, 265(5176), 1231â1234.

Authors 10

Kin-ya Akiyama (first)
Kim-ya Yokota (additional)
Susumu Kagawa (additional)
Naoki Shimbara (additional)
Tomohiro Tamura (additional)
Hiroshi Akioka (additional)
Hans G. Nothwang (additional)
Chiseko Noda (additional)
Keiji Tanaka (additional)
Akira Ichihara (additional)

References 30 Referenced 151

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:01 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 6:04 p.m.)
Indexed	3 weeks ago (Aug. 5, 2025, 8:13 a.m.)
Issued	31 years ago (Aug. 26, 1994)
Published	31 years ago (Aug. 26, 1994)
Published Print	31 years ago (Aug. 26, 1994)

Funders 0

None

BibTeX

@article{Akiyama_1994, title={cDNA Cloning and Interferon γ Down-Regulation of Proteasomal Aubunits X and Y}, volume={265}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8066462}, DOI={10.1126/science.8066462}, number={5176}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Akiyama, Kin-ya and Yokota, Kim-ya and Kagawa, Susumu and Shimbara, Naoki and Tamura, Tomohiro and Akioka, Hiroshi and Nothwang, Hans G. and Noda, Chiseko and Tanaka, Keiji and Ichihara, Akira}, year={1994}, month=aug, pages={1231–1234} }

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