DOI: 10.1126/science.8052854. Inhibition of NF-κB by Sodium Salicylate and Aspirin

Inhibition of NF-κB by Sodium Salicylate and Aspirin

10.1126/science.8052854

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The transcription factor nuclear factor-κB (NF-κB) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-κB, which further explains the mechanism of action of these drugs. This inhibition prevented the degradation of the NF-κB inhibitor, IκB, and therefore NF-κB was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF-κB-dependent transcription from the Igκ enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.

Bibliography

Kopp, E., & Ghosh, S. (1994). Inhibition of NF-ÎºB by Sodium Salicylate and Aspirin. Science, 265(5174), 956â959.

Authors 2

Elizabeth Kopp (first)
Sankar Ghosh (additional)

References 27 Referenced 1,422

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DUH, E.J., TUMOR NECROSIS FACTOR A ACTIVATES HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 THROUGH INDUCTION OF NUCLEAR FACTOR BINDING TO THE NF-KAPPA-B SITES IN THE LONG TERMINAL REPEAT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 5974 (1989). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1989)
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GRIFFIN, G.E., ACTIVATION OF HIV GENE-EXPRESSION DURING MONOCYTE DIFFERENTIATION BY INDUCTION OF NF-KAPPA-B, NATURE 339: 70 (1989). (10.1038/339070a0) / NATURE (1989)
GRILLI, M, INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 143 143: 1 (1993). / INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 143 (1993)
HUNT, C, CONSERVED FEATURES OF EUKARYOTIC HSP70 GENES REVEALED BY COMPARISON WITH THE NUCLEOTIDE-SEQUENCE OF HUMAN HSP70, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 6455 (1985). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1985)
JURIVICH, D.A., EFFECT OF SODIUM-SALICYLATE ON THE HUMAN HEAT-SHOCK RESPONSE, SCIENCE 255: 1243 (1992). (10.1126/science.1546322) / SCIENCE (1992)
MACILWAIN, C, ASPIRIN ON TRIAL AS HIV TREATMENT, NATURE 364: 369 (1993). / NATURE (1993)
10.1126/science.250.4983.1002
10.1126/science.250.4983.1004
MOSSER, D.D., COORDINATE CHANGES IN HEAT-SHOCK ELEMENT-BINDING ACTIVITY AND HSP70 GENE-TRANSCRIPTION RATES IN HUMAN-CELLS, MOLECULAR AND CELLULAR BIOLOGY 8: 4736 (1988). / MOLECULAR AND CELLULAR BIOLOGY (1988)
10.1038/326711a0
NEISH, A.S., FUNCTIONAL-ANALYSIS OF THE HUMAN VASCULAR CELL-ADHESION MOLECULE-1 PROMOTER, JOURNAL OF EXPERIMENTAL MEDICINE 176: 1583 (1992). (10.1084/jem.176.6.1583) / JOURNAL OF EXPERIMENTAL MEDICINE (1992)
PALMOSKI, M.J., EFFECTS OF SALICYLATE AND INDOMETHACIN ON GLYCOSAMINOGLYCAN AND PROSTAGLANDIN-E2 SYNTHESIS IN INTACT CANINE KNEE CARTILAGE EXVIVO, ARTHRITIS AND RHEUMATISM 27: 398 (1984). (10.1002/art.1780270406) / ARTHRITIS AND RHEUMATISM (1984)
PALMOSKI, M.J., CORRECTION, ARTHRITIS AND RHEUMATISM 28: 237 (1985). / ARTHRITIS AND RHEUMATISM (1985)
POMERANTZ, R.J., CELLS NONPRODUCTIVELY INFECTED WITH HIV-1 EXHIBIT AN ABERRANT PATTERN OF VIRAL-RNA EXPRESSION - A MOLECULAR-MODEL FOR LATENCY, CELL 61: 1271 (1990). (10.1016/0092-8674(90)90691-7) / CELL (1990)
Rainsford K. D. Aspirin and the Salicylates (1984).
SCHREIBER, E, RAPID DETECTION OF OCTAMER BINDING-PROTEINS WITH MINI-EXTRACTS, PREPARED FROM A SMALL NUMBER OF CELLS, NUCLEIC ACIDS RESEARCH 17: 6419 (1989). (10.1093/nar/17.15.6419) / NUCLEIC ACIDS RESEARCH (1989)
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VANE, J. R., STROKE 4 12: 12 (1990). / STROKE (1990)
WEISSMANN, G, ASPIRIN, SCIENTIFIC AMERICAN 264: 84 (1991). / SCIENTIFIC AMERICAN (1991)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:01 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:01 p.m.)
Indexed	2 days, 4 hours ago (Aug. 24, 2025, 7:05 p.m.)
Issued	31 years ago (Aug. 12, 1994)
Published	31 years ago (Aug. 12, 1994)
Published Print	31 years ago (Aug. 12, 1994)

Funders 0

None

BibTeX

@article{Kopp_1994, title={Inhibition of NF-κB by Sodium Salicylate and Aspirin}, volume={265}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8052854}, DOI={10.1126/science.8052854}, number={5174}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Kopp, Elizabeth and Ghosh, Sankar}, year={1994}, month=aug, pages={956–959} }

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