DOI: 10.1126/science.8023163. Adaptive Mutation by Deletions in Small Mononucleotide Repeats

Adaptive Mutation by Deletions in Small Mononucleotide Repeats

10.1126/science.8023163

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Adaptive reversion of a +1 frameshift mutation in Escherichia coli , which requires homologous recombination functions, is shown here to occur by -1 deletions in regions of small mononucleotide repeats. This pattern makes improbable recombinational mechanisms for adaptive mutation in which blocks of sequences are transferred into the mutating gene, and it supports mechanisms that use DNA polymerase errors. The pattern appears similar to that of mutations found in yeast cells and in hereditary colon cancer cells that are deficient in mismatch repair. These results suggest a recombinational mechanism for adaptive mutation that functions through polymerase errors that persist as a result of a deficiency in post-synthesis mismatch repair.

Bibliography

Rosenberg, S. M., Longerich, S., Gee, P., & Harris, R. S. (1994). Adaptive Mutation by Deletions in Small Mononucleotide Repeats. Science, 265(5170), 405â407.

Authors 4

Susan M. Rosenberg (first)
Simonne Longerich (additional)
Pauline Gee (additional)
Reuben S. Harris (additional)

References 35 Referenced 177

10.1126/science.8484121
AMUNDSEN, S.K., RECD - THE GENE FOR AN ESSENTIAL 3RD SUBUNIT OF EXONUCLEASE-V, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 5558 (1986). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1986)
BIEK, D.P., IDENTIFICATION AND CHARACTERIZATION OF RECD, A GENE AFFECTING PLASMID MAINTENANCE AND RECOMBINATION IN ESCHERICHIA-COLI, JOURNAL OF BACTERIOLOGY 167: 594 (1986). (10.1128/jb.167.2.594-603.1986) / JOURNAL OF BACTERIOLOGY (1986)
10.1093/genetics/128.4.695
10.1038/335142a0
DEMEREC, M, SELFERS - ATTRIBUTED TO UNEQUAL CROSSOVERS IN SALMONELLA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 48: 1696 (1962). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1962)
FISHEL, R, THE HUMAN MUTATOR GENE HOMOLOG MSH2 AND ITS ASSOCIATION WITH HEREDITARY NONPOLYPOSIS COLON-CANCER, CELL 75: 1027 (1993). (10.1016/0092-8674(93)90546-3) / CELL (1993)
10.1016/0092-8674(93)90330-S
FOSTER, P.L., ADAPTIVE MUTATION - THE USES OF ADVERSITY, ANNUAL REVIEW OF MICROBIOLOGY 47: 467 (1993). (10.1146/annurev.mi.47.100193.002343) / ANNUAL REVIEW OF MICROBIOLOGY (1993)
10.1093/genetics/131.4.783
GRAFEN, A, ORIGIN OF MUTANTS DISPUTED, NATURE 336: 525 (1988). (10.1038/336525b0) / NATURE (1988)
HALL, B. G., GENETICS 126: 5 (1990). (10.1093/genetics/126.1.5) / GENETICS (1990)
10.1126/science.8146657
Hastings, P. J., Encyclopedia of Immunology: 602 (1992). / Encyclopedia of Immunology (1992)
IONOV, Y, UBIQUITOUS SOMATIC MUTATIONS IN SIMPLE REPEATED SEQUENCES REVEAL A NEW MECHANISM FOR COLONIC CARCINOGENESIS, NATURE 363: 558 (1993). (10.1038/363558a0) / NATURE (1993)
JAYARAMAN, R, CAIRNSIAN MUTAGENESIS IN ESCHERICHIA-COLI - GENETIC-EVIDENCE FOR 2 PATHWAYS REGULATED BY MUTS AND MUTL GENES, JOURNAL OF GENETICS 71: 23 (1992). (10.1007/BF02927873) / JOURNAL OF GENETICS (1992)
10.1093/genetics/28.6.491
MAGNI, G.E., DIFFERENT RATES OF SPONTANEOUS MTATION DURING MITOSIS AND MEIOSIS IN YEAST, GENETICS 47: 1097 (1962). (10.1093/genetics/47.8.1097) / GENETICS (1962)
Maizels, N., Cell 48: 359 (1987). / Cell (1987)
MCGILL, C, CURR GENET 23: 430 (1993). (10.1007/BF00312630) / CURR GENET (1993)
Miller J. H. A Short Course in Bacterial Genetics (1992).
PARSONS, R, HYPERMUTABILITY AND MISMATCH REPAIR DEFICIENCY IN RER+ TUMOR-CELLS, CELL 75: 1227 (1993). (10.1016/0092-8674(93)90331-J) / CELL (1993)
PASZEWSKI, A, SELFERS + HIGH MUTATION RATE DURING MEIOSIS IN ASCOBOLUS IMMERSUS, NATURE 204: 809 (1964). / NATURE (1964)
RIPLEY, L.S., FRAMESHIFT MUTATION - DETERMINANTS OF SPECIFICITY, ANNUAL REVIEW OF GENETICS 24: 189 (1990). (10.1146/annurev.ge.24.120190.001201) / ANNUAL REVIEW OF GENETICS (1990)
ROSENBERG, S.M., THE SPLIT-END MODEL FOR HOMOLOGOUS RECOMBINATION AT DOUBLE-STRAND BREAKS AND AT CHI, BIOCHIMIE 73: 385 (1991). (10.1016/0300-9084(91)90105-A) / BIOCHIMIE (1991)
ROTH, J, GENETICS 132: 865 (1992). (10.1093/genetics/132.4.865) / GENETICS (1992)
ROTHENFLUH, H, TODAY'S LIFE SCIENCE 5: 8 (1993). / TODAY'S LIFE SCIENCE (1993)
Stahl, F. W., Nature 335: 112 (1988). / Nature (1988)
Steele E. J. Somatic Selection and Adaptive Evolution (1979). (10.1007/978-1-4615-9793-3)
STRAND, M, DESTABILIZATION OF TRACTS OF SIMPLE REPETITIVE DNA IN YEAST BY MUTATIONS AFFECTING DNA MISMATCH REPAIR, NATURE 365: 274 (1993). (10.1038/365274a0) / NATURE (1993)
STRAUSS, B.S., THE ORIGIN OF POINT MUTATIONS IN HUMAN TUMOR-CELLS, CANCER RESEARCH 52: 249 (1992). / CANCER RESEARCH (1992)
STREISINGER, G, FRAMESHIFT MUTATIONS AND GENETIC CODE, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 31: 77 (1966). (10.1101/SQB.1966.031.01.014) / COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY (1966)
Thaler, D. S., The Bacterial Chromosome: 445 (1990). / The Bacterial Chromosome (1990)
THALER, D.S., RECOMBINATION OF BACTERIOPHAGE-LAMBDA IN RECD MUTANTS OF ESCHERICHIA-COLI, GENOME 31: 53 (1989). (10.1139/g89-013) / GENOME (1989)
THALER, D.S., SEX IS FOR SISTERS - INTRAGENOMIC RECOMBINATION AND HOMOLOGY-DEPENDENT MUTATION AS SOURCES OF EVOLUTIONARY VARIATION, TRENDS IN ECOLOGY & EVOLUTION 9: 108 (1994). (10.1016/0169-5347(94)90208-9) / TRENDS IN ECOLOGY & EVOLUTION (1994)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 8:01 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:05 p.m.)
Indexed	4 weeks, 1 day ago (Aug. 7, 2025, 4:25 p.m.)
Issued	31 years, 1 month ago (July 15, 1994)
Published	31 years, 1 month ago (July 15, 1994)
Published Print	31 years, 1 month ago (July 15, 1994)

Funders 0

None

BibTeX

@article{Rosenberg_1994, title={Adaptive Mutation by Deletions in Small Mononucleotide Repeats}, volume={265}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8023163}, DOI={10.1126/science.8023163}, number={5170}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Rosenberg, Susan M. and Longerich, Simonne and Gee, Pauline and Harris, Reuben S.}, year={1994}, month=jul, pages={405–407} }

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    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1994,
        7,
        15
      ]
    ]
  }
}