DOI: 10.1126/science.8009224. Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

10.1126/science.8009224

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Maternal sources of transforming growth factor-β1 (TGF-β1) are shown here to contribute to the normal appearance and perinatal survival of TGF-β1 null newborn mice. Labeled TGF-β1 crossed the placenta and was recovered intact from various tissues after oral administration to mouse pups. TGFβ-1 protein was also detected in cells recovered from breast milk. In immunohistochemical analyses, TGF-β1 null embryos and null newborn pups born to TGF-β1 heterozygotes stained positive for TGF-β1, whereas those born to a null female were negative and had severe cardiac abnormalities. These results suggest an important role for maternal sources of TGF-β1 during development and, more generally, provide evidence for maternal rescue of targeted gene disruption in the fetus.

Bibliography

Letterio, J. J., Geiser, A. G., Kulkarni, A. B., Roche, N. S., Sporn, M. B., & Roberts, A. B. (1994). Maternal Rescue of Transforming Growth Factor-Î² 1 Null Mice. Science, 264(5167), 1936â1938.

Authors 6

John J. Letterio (first)
Andrew G. Geiser (additional)
Ashok B. Kulkarni (additional)
Nanette S. Roche (additional)
Michael B. Sporn (additional)
Anita B. Roberts (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:01 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 12:36 a.m.)
Indexed	1 month ago (July 26, 2025, 5:33 a.m.)
Issued	31 years, 2 months ago (June 24, 1994)
Published	31 years, 2 months ago (June 24, 1994)
Published Print	31 years, 2 months ago (June 24, 1994)

Funders 0

None

BibTeX

@article{Letterio_1994, title={Maternal Rescue of Transforming Growth Factor-β 1 Null Mice}, volume={264}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8009224}, DOI={10.1126/science.8009224}, number={5167}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Letterio, John J. and Geiser, Andrew G. and Kulkarni, Ashok B. and Roche, Nanette S. and Sporn, Michael B. and Roberts, Anita B.}, year={1994}, month=jun, pages={1936–1938} }

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