DOI: 10.1126/science.7997877. Cell Cycle Control and Cancer

10.1126/science.7997877

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Multiple genetic changes occur during the evolution of normal cells into cancer cells. This evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair, and segregate the genome. Recent advances in our understanding of the cell cycle reveal how fidelity is normally achieved by the coordinated activity of cyclin-dependent kinases, checkpoint controls, and repair pathways and how this fidelity can be abrogated by specific genetic changes. These insights suggest molecular mechanisms for cellular transformation and may help to identify potential targets for improved cancer therapies.

Bibliography

Hartwell, L. H., & Kastan, M. B. (1994). Cell Cycle Control and Cancer. Science, 266(5192), 1821â1828.

Authors 2

Leland H. Hartwell (first)
Michael B. Kastan (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:01 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:28 p.m.)
Indexed	2 weeks, 5 days ago (Aug. 7, 2025, 4:51 p.m.)
Issued	30 years, 8 months ago (Dec. 16, 1994)
Published	30 years, 8 months ago (Dec. 16, 1994)
Published Print	30 years, 8 months ago (Dec. 16, 1994)

Funders 0

None

BibTeX

@article{Hartwell_1994, title={Cell Cycle Control and Cancer}, volume={266}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7997877}, DOI={10.1126/science.7997877}, number={5192}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Hartwell, Leland H. and Kastan, Michael B.}, year={1994}, month=dec, pages={1821–1828} }

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  "abstract": "<jats:p>Multiple genetic changes occur during the evolution of normal cells into cancer cells. This evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair, and segregate the genome. Recent advances in our understanding of the cell cycle reveal how fidelity is normally achieved by the coordinated activity of cyclin-dependent kinases, checkpoint controls, and repair pathways and how this fidelity can be abrogated by specific genetic changes. These insights suggest molecular mechanisms for cellular transformation and may help to identify potential targets for improved cancer therapies.</jats:p>",
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