DOI: 10.1126/science.7907431. Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

10.1126/science.7907431

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Cultured embryonic cortical neurons from rats were used to explore mechanisms of activity-dependent neuronal survival. Cell survival was increased by the activation of voltage-sensitive calcium channels (VSCCs) but not by activation of N -methyl-D-aspartate receptors. These effects correlated with the expression of brain-derived neurotrophic factor (BDNF) induced by these two classes of calcium channels. Antibodies to BDNF (which block intracellular signaling by BDNF, but not by nerve growth factor, NT3, or NT4/5) reduced the survival of cortical neurons and reversed the VSCC-mediated increase in survival. Thus, endogenous BDNF is a trophic factor for cortical neurons whose expression is VSCC-regulated and that functions in the VSCC-dependent survival of these neurons.

Bibliography

Ghosh, A., Carnahan, J., & Greenberg, M. E. (1994). Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons. Science, 263(5153), 1618â1623.

Authors 3

Anirvan Ghosh (first)
Josette Carnahan (additional)
Michael E. Greenberg (additional)

References 38 Referenced 807

10.1126/science.1715095
BARDE, Y.A., SENSORY NEURONS IN CULTURE - CHANGING REQUIREMENTS FOR SURVIVAL FACTORS DURING EMBRYONIC-DEVELOPMENT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 77: 1199 (1980). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1980)
BAYER, S.A., DEVELOPMENT OF LAYER-I AND THE SUBPLATE IN THE RAT NEOCORTEX, EXPERIMENTAL NEUROLOGY 107: 48 (1990). (10.1016/0014-4886(90)90062-W) / EXPERIMENTAL NEUROLOGY (1990)
Bayer S. A. Neocortical Development (1991).
BLACK, I.B., EFFECTS OF SURGICAL DECENTRALIZATION AND NERVE GROWTH-FACTOR ON MATURATION OF ADRENERGIC NEURONS IN A MOUSE SYMPATHETIC-GANGLION, JOURNAL OF NEUROCHEMISTRY 19: 1367 (1972). (10.1111/j.1471-4159.1972.tb01461.x) / JOURNAL OF NEUROCHEMISTRY (1972)
BONNI A unpublished data.
CASTREN, E, LIGHT REGULATES EXPRESSION OF BRAIN-DERIVED NEUROTROPHIC FACTOR MESSENGER-RNA IN RAT VISUAL-CORTEX, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89: 9444 (1992). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1992)
CHALAZONITIS, A, ELEVATED POTASSIUM INDUCES MORPHOLOGICAL-DIFFERENTIATION OF DORSAL-ROOT GANGLIONIC NEURONS IN DISSOCIATED CELL-CULTURE, DEVELOPMENTAL BIOLOGY 78: 173 (1980). (10.1016/0012-1606(80)90327-9) / DEVELOPMENTAL BIOLOGY (1980)
CHOI, D.W., CALCIUM-MEDIATED NEUROTOXICITY - RELATIONSHIP TO SPECIFIC CHANNEL TYPES AND ROLE IN ISCHEMIC DAMAGE, TRENDS IN NEUROSCIENCES 11: 465 (1988). (10.1016/0166-2236(88)90200-7) / TRENDS IN NEUROSCIENCES (1988)
10.1016/0003-2697(87)90021-2
COLLINS, F, THE ROLE OF DIHYDROPYRIDINE-SENSITIVE VOLTAGE-GATED CALCIUM CHANNELS IN POTASSIUM-MEDIATED NEURONAL SURVIVAL, BRAIN RESEARCH 502: 99 (1989). (10.1016/0006-8993(89)90465-4) / BRAIN RESEARCH (1989)
COLLINS, F, SUSTAINED INCREASE IN INTRACELLULAR CALCIUM PROMOTES NEURONAL SURVIVAL, JOURNAL OF NEUROSCIENCE 11: 2582 (1991). (10.1523/JNEUROSCI.11-08-02582.1991) / JOURNAL OF NEUROSCIENCE (1991)
FRANKLIN, J.L., SUPPRESSION OF PROGRAMMED NEURONAL DEATH BY SUSTAINED ELEVATION OF CYTOPLASMIC CALCIUM, TRENDS IN NEUROSCIENCES 15: 501 (1992). (10.1016/0166-2236(92)90103-F) / TRENDS IN NEUROSCIENCES (1992)
FURBER, S, NATURALLY-OCCURRING NEURON DEATH IN THE CILIARY GANGLION OF THE CHICK-EMBRYO FOLLOWING REMOVAL OF PREGANGLIONIC INPUT - EVIDENCE FOR THE ROLE OF AFFERENTS IN GANGLION-CELL SURVIVAL, JOURNAL OF NEUROSCIENCE 7: 1816 (1987). (10.1523/JNEUROSCI.07-06-01816.1987) / JOURNAL OF NEUROSCIENCE (1987)
10.1126/science.3175637
GALLO, V, THE ROLE OF DEPOLARIZATION IN THE SURVIVAL AND DIFFERENTIATION OF CEREBELLAR GRANULE CELLS IN CULTURE, JOURNAL OF NEUROSCIENCE 7: 2203 (1987). (10.1523/JNEUROSCI.07-07-02203.1987) / JOURNAL OF NEUROSCIENCE (1987)
GHOSH A unpublished data.
10.1126/science.8097062
GUILLERY, R.W., QUANTITATIVE STUDIES OF TRANSNEURONAL ATROPHY IN DORSAL LATERAL GENICULATE NUCLEUS OF CATS AND KITTENS, JOURNAL OF COMPARATIVE NEUROLOGY 149: 423 (1973). (10.1002/cne.901490403) / JOURNAL OF COMPARATIVE NEUROLOGY (1973)
HASHISAKI, G.T., EFFECTS OF UNILATERAL COCHLEA REMOVAL ON ANTEROVENTRAL COCHLEAR NUCLEUS NEURONS IN DEVELOPING GERBILS, JOURNAL OF COMPARATIVE NEUROLOGY 283: 465 (1989). (10.1002/cne.902830402) / JOURNAL OF COMPARATIVE NEUROLOGY (1989)
HOFER, M, REGIONAL DISTRIBUTION OF BRAIN-DERIVED NEUROTROPHIC FACTOR MESSENGER-RNA IN THE ADULT-MOUSE BRAIN, EMBO JOURNAL 9: 2459 (1990). (10.1002/j.1460-2075.1990.tb07423.x) / EMBO JOURNAL (1990)
ISACKSON, P.J., BDNF MESSENGER-RNA EXPRESSION IS INCREASED IN ADULT-RAT FOREBRAIN AFTER LIMBIC SEIZURES - TEMPORAL PATTERNS OF INDUCTION DISTINCT FROM NGF, NEURON 6: 937 (1991). (10.1016/0896-6273(91)90234-Q) / NEURON (1991)
KOIKE, T, ROLE OF CA-2+ CHANNELS IN THE ABILITY OF MEMBRANE DEPOLARIZATION TO PREVENT NEURONAL DEATH INDUCED BY TROPHIC-FACTOR DEPRIVATION - EVIDENCE THAT LEVELS OF INTERNAL CA-2+ DETERMINE NERVE GROWTH-FACTOR DEPENDENCE OF SYMPATHETIC-GANGLION CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 6421 (1989). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1989)
KOIKE, T, EVIDENCE THAT NERVE GROWTH-FACTOR DEPENDENCE OF SYMPATHETIC NEURONS FOR SURVIVAL INVITRO MAY BE DETERMINED BY LEVELS OF CYTOPLASMIC FREE CA2+, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 3892 (1991). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1991)
KOKAIA, Z, COEXPRESSION OF NEUROTROPHINS AND THEIR RECEPTORS IN NEURONS OF THE CENTRAL-NERVOUS-SYSTEM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 6711 (1993). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1993)
LARMET, Y, INTRACELLULAR CALCIUM REGULATES THE SURVIVAL OF EARLY SENSORY NEURONS BEFORE THEY BECOME DEPENDENT ON NEUROTROPHIC FACTORS, NEURON 9: 563 (1992). (10.1016/0896-6273(92)90193-H) / NEURON (1992)
10.1016/0012-1606(85)90402-6
MADERDRUT, J.L., ENHANCEMENT OF NATURALLY-OCCURRING CELL-DEATH IN THE SYMPATHETIC AND PARASYMPATHETIC GANGLIA OF THE CHICKEN-EMBRYO FOLLOWING BLOCKADE OF GANGLIONIC TRANSMISSION, BRAIN RESEARCH 444: 189 (1988). (10.1016/0006-8993(88)90928-6) / BRAIN RESEARCH (1988)
MAISONPIERRE, P.C., NT-3, BDNF, AND NGF IN THE DEVELOPING RAT NERVOUS-SYSTEM - PARALLEL AS WELL AS RECIPROCAL PATTERNS OF EXPRESSION, NEURON 5: 501 (1990). (10.1016/0896-6273(90)90089-X) / NEURON (1990)
10.1126/science.2035024
MIRANDA, R.C., NEURONAL COLOCALIZATION OF MESSENGER-RNAS FOR NEUROTROPHINS AND THEIR RECEPTORS IN THE DEVELOPING CENTRAL-NERVOUS-SYSTEM SUGGESTS A POTENTIAL FOR AUTOCRINE INTERACTIONS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 6439 (1993). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1993)
NISHI, R, EFFECTS OF HIGH K+ CONCENTRATIONS ON THE GROWTH AND DEVELOPMENT OF CILIARY GANGLION NEURONS IN CELL-CULTURE, DEVELOPMENTAL BIOLOGY 87: 301 (1981). (10.1016/0012-1606(81)90153-6) / DEVELOPMENTAL BIOLOGY (1981)
PASIC, T.R., RAPID CHANGES IN COCHLEAR NUCLEUS CELL-SIZE FOLLOWING BLOCKADE OF AUDITORY-NERVE ELECTRICAL-ACTIVITY IN GERBILS, JOURNAL OF COMPARATIVE NEUROLOGY 283: 474 (1989). (10.1002/cne.902830403) / JOURNAL OF COMPARATIVE NEUROLOGY (1989)
SCOTT, B.S., POTASSIUM CONCENTRATION AND NUMBER OF NEURONS IN CULTURES OF DISSOCIATED GANGLIA, EXPERIMENTAL NEUROLOGY 27: 16 (1970). (10.1016/0014-4886(70)90197-4) / EXPERIMENTAL NEUROLOGY (1970)
TYMIANSKI, M, SOURCE SPECIFICITY OF EARLY CALCIUM NEUROTOXICITY IN CULTURED EMBRYONIC SPINAL NEURONS, JOURNAL OF NEUROSCIENCE 13: 2085 (1993). (10.1523/JNEUROSCI.13-05-02085.1993) / JOURNAL OF NEUROSCIENCE (1993)
10.1126/science.1496379
ZAFRA, F, ACTIVITY DEPENDENT REGULATION OF BDNF AND NGF MESSENGER-RNAS IN THE RAT HIPPOCAMPUS IS MEDIATED BY NON-NMDA GLUTAMATE RECEPTORS, EMBO JOURNAL 9: 3545 (1990). (10.1002/j.1460-2075.1990.tb07564.x) / EMBO JOURNAL (1990)
ZAFRA, F, REGULATION OF BRAIN-DERIVED NEUROTROPHIC FACTOR AND NERVE GROWTH-FACTOR MESSENGER-RNA IN PRIMARY CULTURES OF HIPPOCAMPAL-NEURONS AND ASTROCYTES, JOURNAL OF NEUROSCIENCE 12: 4793 (1992). (10.1523/JNEUROSCI.12-12-04793.1992) / JOURNAL OF NEUROSCIENCE (1992)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:01 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:15 p.m.)
Indexed	5 days, 18 hours ago (Aug. 21, 2025, 2:08 p.m.)
Issued	31 years, 5 months ago (March 18, 1994)
Published	31 years, 5 months ago (March 18, 1994)
Published Print	31 years, 5 months ago (March 18, 1994)

Funders 0

None

BibTeX

@article{Ghosh_1994, title={Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons}, volume={263}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7907431}, DOI={10.1126/science.7907431}, number={5153}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Ghosh, Anirvan and Carnahan, Josette and Greenberg, Michael E.}, year={1994}, month=mar, pages={1618–1623} }

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