DOI: 10.1126/science.7886457. Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus

Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus

10.1126/science.7886457

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The neurotrophins are signaling factors important for the differentiation and survival of distinct neuronal populations during development. To test whether the neurotrophins also function in the mature nervous system, the effects of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophic factor 3 (NT-3) on the strength of synaptic transmission in hippocampal slices were determined. Application of BDNF or NT-3 produced a dramatic and sustained (2 to 3 hours) enhancement of synaptic strength at the Schaffer collateral-CA1 synapses; NGF was without significant effect. The enhancement was blocked by K252a, an inhibitor of receptor tyrosine kinases. BDNF and NT-3 decreased paired-pulse facilitation, which is consistent with a possible presynaptic modification. Long-term potentiation could still be elicited in slices previously potentiated by exposure to the neurotrophic factors, which implies that these two forms of plasticity may use at least partially independent cellular mechanisms.

Bibliography

Kang, H., & Schuman, E. M. (1995). Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus. Science, 267(5204), 1658â1662.

Authors 2

Hyejin Kang (first)
Erin M. Schuman (additional)

References 19 Referenced 1,133

BELLINGER, F.P., INTERLEUKIN-1-BETA INHIBITS SYNAPTIC STRENGTH AND LONG-TERM POTENTIATION IN THE RAT CA1 HIPPOCAMPUS, BRAIN RESEARCH 628: 227 (1993). (10.1016/0006-8993(93)90959-Q) / BRAIN RESEARCH (1993)
BERG, M.M., K-252A INHIBITS NERVE GROWTH FACTOR-INDUCED TRK PROTOONCOGENE TYROSINE PHOSPHORYLATION AND KINASE-ACTIVITY, JOURNAL OF BIOLOGICAL CHEMISTRY 267: 13 (1992). (10.1016/S0021-9258(18)48447-5) / JOURNAL OF BIOLOGICAL CHEMISTRY (1992)
ENFORS, P, EUR J NEUROSCI 4: 1140 (1992). (10.1111/j.1460-9568.1992.tb00141.x) / EUR J NEUROSCI (1992)
FREY, U, ANISOMYCIN, AN INHIBITOR OF PROTEIN-SYNTHESIS, BLOCKS LATE PHASES OF LTP PHENOMENA IN THE HIPPOCAMPAL CA1 REGION INVITRO, BRAIN RESEARCH 452: 57 (1988). (10.1016/0006-8993(88)90008-X) / BRAIN RESEARCH (1988)
10.1126/science.7907431
ISACKSON, P.J., BDNF MESSENGER-RNA EXPRESSION IS INCREASED IN ADULT-RAT FOREBRAIN AFTER LIMBIC SEIZURES - TEMPORAL PATTERNS OF INDUCTION DISTINCT FROM NGF, NEURON 6: 937 (1991). (10.1016/0896-6273(91)90234-Q) / NEURON (1991)
KANG H unpublished data.
KATZ, B, JOURNAL OF PHYSIOLOGY-LONDON 195: 481 (1968). (10.1113/jphysiol.1968.sp008469) / JOURNAL OF PHYSIOLOGY-LONDON (1968)
KLEIN, R, THE TRKB TYROSINE PROTEIN-KINASE GENE CODES FOR A 2ND NEUROGENIC RECEPTOR THAT LACKS THE CATALYTIC KINASE DOMAIN, CELL 61: 647 (1990). (10.1016/0092-8674(90)90476-U) / CELL (1990)
KNUSEL, B, K-252B IS A SELECTIVE AND NONTOXIC INHIBITOR OF NERVE GROWTH-FACTOR ACTION ON CULTURED BRAIN NEURONS, JOURNAL OF NEUROCHEMISTRY 57: 955 (1991). (10.1111/j.1471-4159.1991.tb08243.x) / JOURNAL OF NEUROCHEMISTRY (1991)
LAMBALLE, F, TRKC, A NEW MEMBER OF THE TRK FAMILY OF TYROSINE PROTEIN-KINASES, IS A RECEPTOR FOR NEUROTROPHIN-3, CELL 66: 967 (1991). (10.1016/0092-8674(91)90442-2) / CELL (1991)
LOHOF, A.M., POTENTIATION OF DEVELOPING NEUROMUSCULAR SYNAPSES BY THE NEUROTROPHINS NT-3 AND BDNF, NATURE 363: 350 (1993). (10.1038/363350a0) / NATURE (1993)
Lu, B., Proceedings of the National Academy of Sciences of the United States of America 88: 6289 (1991). / Proceedings of the National Academy of Sciences of the United States of America (1991)
MANABE, T, MODULATION OF SYNAPTIC TRANSMISSION AND LONG-TERM POTENTIATION - EFFECTS ON PAIRED-PULSE FACILITATION AND EPSC VARIANCE IN THE CA1 REGION OF THE HIPPOCAMPUS, JOURNAL OF NEUROPHYSIOLOGY 70: 1451 (1993). (10.1152/jn.1993.70.4.1451) / JOURNAL OF NEUROPHYSIOLOGY (1993)
10.1126/science.8066450
10.1016/0896-6273(92)90067-N
TAPLEY, P, K252A IS A SELECTIVE INHIBITOR OF THE TYROSINE PROTEIN-KINASE ACTIVITY OF THE TRK FAMILY OF ONCOGENES AND NEUROTROPHIN RECEPTORS, ONCOGENE 7: 371 (1992). / ONCOGENE (1992)
VASQUEZ, M.E., NEUROREPORT 2: 593 (1991). (10.1097/00001756-199110000-00010) / NEUROREPORT (1991)
ZAFRA, F, ACTIVITY DEPENDENT REGULATION OF BDNF AND NGF MESSENGER-RNAS IN THE RAT HIPPOCAMPUS IS MEDIATED BY NON-NMDA GLUTAMATE RECEPTORS, EMBO JOURNAL 9: 3545 (1990). (10.1002/j.1460-2075.1990.tb07564.x) / EMBO JOURNAL (1990)

Dates

Type	When
Created	18 years, 9 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:29 p.m.)
Indexed	3 weeks, 2 days ago (Aug. 3, 2025, 7:06 p.m.)
Issued	30 years, 5 months ago (March 17, 1995)
Published	30 years, 5 months ago (March 17, 1995)
Published Print	30 years, 5 months ago (March 17, 1995)

Funders 0

None

BibTeX

@article{Kang_1995, title={Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus}, volume={267}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7886457}, DOI={10.1126/science.7886457}, number={5204}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Kang, Hyejin and Schuman, Erin M.}, year={1995}, month=mar, pages={1658–1662} }

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