Crystal Structure of the Tetramerization Domain of the p53 Tumor Suppressor at 1.7 Angstroms
10.1126/science.7878469
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The p53 protein is a tetrameric transcription factor that plays a central role in the prevention of neoplastic transformation. Oligomerization appears to be essential for the tumor suppressing activity of p53 because oligomerization-deficient p53 mutants cannot suppress the growth of carcinoma cell lines. The crystal structure of the tetramerization domain of p53 (residues 325 to 356) was determined at 1.7 angstrom resolution and refined to a crystallographic R factor of 19.2 percent. The monomer, which consists of a β strand and an α helix, associates with a second monomer across an antiparallel β sheet and an antiparallel helix-helix interface to form a dimer. Two of these dimers associate across a second and distinct parallel helix-helix interface to form the tetramer.

Bibliography

Jeffrey, P. D., Gorina, S., & Pavletich, N. P. (1995). Crystal Structure of the Tetramerization Domain of the p53 Tumor Suppressor at 1.7 Angstroms. Science, 267(5203), 1498–1502.

Authors 3
  1. Philip D. Jeffrey (first)
  2. Svetlana Gorina (additional)
  3. Nikola P. Pavletich (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited 1 year, 7 months ago (Jan. 14, 2024, 11:26 p.m.)
Indexed 5 days, 15 hours ago (Aug. 27, 2025, 11:32 a.m.)
Issued 30 years, 5 months ago (March 10, 1995)
Published 30 years, 5 months ago (March 10, 1995)
Published Print 30 years, 5 months ago (March 10, 1995)
Funders 0

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@article{Jeffrey_1995, title={Crystal Structure of the Tetramerization Domain of the p53 Tumor Suppressor at 1.7 Angstroms}, volume={267}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7878469}, DOI={10.1126/science.7878469}, number={5203}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Jeffrey, Philip D. and Gorina, Svetlana and Pavletich, Nikola P.}, year={1995}, month=mar, pages={1498–1502} }