DOI: 10.1126/science.7863326. Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell Clones

Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell Clones

10.1126/science.7863326

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Recognition by natural killer (NK) cells of major histocompatibility complex (MHC) class I molecules on target cells inhibits NK-mediated lysis. Here, inhibition of NK clones by HLA-B*2705 molecules mutated at single amino acids in the peptide binding site varied among HLA-B*2705-specific NK clones. In addition, a subset of such NK clones was inhibited by only one of several self peptides loaded onto HLA-B*2705 molecules expressed in peptide transporter-deficient cells, showing that recognition was peptide-specific. These data demonstrate that specific self peptides, complexed with MHC class I, provide protection from NK-mediated lysis.

Bibliography

Malnati, M. S., Peruzzi, M., Parker, K. C., Biddison, W. E., Ciccone, E., Moretta, A., & Long, E. O. (1995). Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell Clones. Science, 267(5200), 1016â1018.

Authors 7

Mauro S. Malnati (first)
Marta Peruzzi (additional)
Kenneth C. Parker (additional)
William E. Biddison (additional)
Ermanno Ciccone (additional)
Alessandro Moretta (additional)
Eric O. Long (additional)

References 31 Referenced 242

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:31 p.m.)
Indexed	3 weeks, 5 days ago (Aug. 6, 2025, 9:59 a.m.)
Issued	30 years, 6 months ago (Feb. 17, 1995)
Published	30 years, 6 months ago (Feb. 17, 1995)
Published Print	30 years, 6 months ago (Feb. 17, 1995)

Funders 0

None

BibTeX

@article{Malnati_1995, title={Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell Clones}, volume={267}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7863326}, DOI={10.1126/science.7863326}, number={5200}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Malnati, Mauro S. and Peruzzi, Marta and Parker, Kenneth C. and Biddison, William E. and Ciccone, Ermanno and Moretta, Alessandro and Long, Eric O.}, year={1995}, month=feb, pages={1016–1018} }

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