DOI: 10.1126/science.7855598. PER Protein Interactions and Temperature Compensation of a Circadian Clock in <i>Drosophila</i>

PER Protein Interactions and Temperature Compensation of a Circadian Clock in Drosophila

10.1126/science.7855598

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The periods of circadian clocks are relatively temperature-insensitive. Indeed, the per L mutation in the Drosophila melanogaster period gene, a central component of the clock, affects temperature compensation as well as period length. The per protein (PER) contains a dimerization domain (PAS) within which the per L mutation is located. Amino acid substitutions at the per L position rendered PER dimerization temperature-sensitive. In addition, another region of PER interacted with PAS, and the per L mutation enhanced this putative intramolecular interaction, which may compete with PAS-PAS intermolecular interactions. Therefore, temperature compensation of circadian period in Drosophila may be due in part to temperature-independent PER activity, which is based on competition between inter- and intramolecular interactions with similar temperature coefficients.

Bibliography

Huang, Z. J., Curtin, K. D., & Rosbash, M. (1995). PER Protein Interactions and Temperature Compensation of a Circadian Clock in Drosophila. Science, 267(5201), 1169â1172.

Authors 3

Zuoshi J. Huang (first)
Kathryn D. Curtin (additional)
Michael Rosbash (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:31 p.m.)
Indexed	1 week, 2 days ago (Aug. 27, 2025, 11:38 a.m.)
Issued	30 years, 6 months ago (Feb. 24, 1995)
Published	30 years, 6 months ago (Feb. 24, 1995)
Published Print	30 years, 6 months ago (Feb. 24, 1995)

Funders 0

None

BibTeX

@article{Huang_1995, title={PER Protein Interactions and Temperature Compensation of a Circadian Clock in Drosophila}, volume={267}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7855598}, DOI={10.1126/science.7855598}, number={5201}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Huang, Zuoshi J. and Curtin, Kathryn D. and Rosbash, Michael}, year={1995}, month=feb, pages={1169–1172} }

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