DOI: 10.1126/science.7792602. Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

10.1126/science.7792602

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integration caused a deletion in the gene encoding MAOA, providing an animal model of MAOA deficiency. In pup brains, serotonin concentrations were increased up to ninefold, and serotonin-like immunoreactivity was present in catecholaminergic neurons. In pup and adult brains, norepinephrine concentrations were increased up to twofold, and cytoarchitectural changes were observed in the somatosensory cortex. Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine. Adults manifested a distinct behavioral syndrome, including enhanced aggression in males.

Bibliography

Cases, O., Seif, I., Grimsby, J., Gaspar, P., Chen, K., Pournin, S., MÃ¼ller, U., Aguet, M., Babinet, C., Shih, J. C., & De Maeyer, E. (1995). Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA. Science, 268(5218), 1763â1766.

Authors 11

Olivier Cases (first)
Isabelle Seif (additional)
Joseph Grimsby (additional)
Patricia Gaspar (additional)
Kevin Chen (additional)
Sandrine Pournin (additional)
Ulrike Müller (additional)
Michel Aguet (additional)
Charles Babinet (additional)
Jean Chen Shih (additional)
Edward De Maeyer (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:52 p.m.)
Indexed	2 days, 21 hours ago (Sept. 3, 2025, 6:03 a.m.)
Issued	30 years, 2 months ago (June 23, 1995)
Published	30 years, 2 months ago (June 23, 1995)
Published Print	30 years, 2 months ago (June 23, 1995)

Funders 0

None

BibTeX

@article{Cases_1995, title={Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA}, volume={268}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7792602}, DOI={10.1126/science.7792602}, number={5218}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Cases, Olivier and Seif, Isabelle and Grimsby, Joseph and Gaspar, Patricia and Chen, Kevin and Pournin, Sandrine and Müller, Ulrike and Aguet, Michel and Babinet, Charles and Shih, Jean Chen and De Maeyer, Edward}, year={1995}, month=jun, pages={1763–1766} }

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