Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
10.1126/science.7754368
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Basic helix-loop-helix (bHLH) proteins are instrumental in determining cell type during development. A bHLH protein, termed NeuroD, for neurogenic differentiation, has now been identified as a differentiation factor for neurogenesis because (i) it is expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation into mature neurons and (ii) ectopic expression of neuroD in Xenopus embryos causes premature differentiation of neuronal precursors. Furthermore, neuroD can convert presumptive epidermal cells into neurons and also act as a neuronal determination gene. However, unlike another previously identified proneural gene (XASH-3), neuroD seems competent to bypass the normal inhibitory influences that usually prevent neurogenesis in ventral and lateral ectoderm and is capable of converting most of the embryonic ectoderm into neurons. The data suggest that neuroD may participate in the terminal differentiation step during vertebrate neuronal development.

Bibliography

Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., & Weintraub, H. (1995). Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein. Science, 268(5212), 836–844.

Authors 6
  1. Jacqueline E. Lee (first)
  2. Stanley M. Hollenberg (additional)
  3. Lauren Snider (additional)
  4. David L. Turner (additional)
  5. Naomi Lipnick (additional)
  6. Harold Weintraub (additional)
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Dates
Type When
Created 18 years, 9 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited 1 year, 7 months ago (Jan. 14, 2024, 11:43 p.m.)
Indexed 3 weeks ago (Aug. 3, 2025, 12:33 a.m.)
Issued 30 years, 3 months ago (May 12, 1995)
Published 30 years, 3 months ago (May 12, 1995)
Published Print 30 years, 3 months ago (May 12, 1995)
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@article{Lee_1995, title={Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein}, volume={268}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7754368}, DOI={10.1126/science.7754368}, number={5212}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Lee, Jacqueline E. and Hollenberg, Stanley M. and Snider, Lauren and Turner, David L. and Lipnick, Naomi and Weintraub, Harold}, year={1995}, month=may, pages={836–844} }