Notch Signaling
10.1126/science.7716513
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans . Studies on the expression, mutant phenotypes, and developmental consequences of unregulated receptor activation have implicated these proteins in a general mechanism of local cell signaling, which includes interactions between equivalent cells and between different cell types. Genetic approaches in flies and worms have identified putative components of the signaling cascade, including a conserved family of extracellular ligands and two cellular factors that may associate with the Notch Intracellular domain. One factor, the Drosophila Suppressor of Hairless protein, is a DNA-binding protein, which suggests that Notch signaling may involve relatively direct signal transmission from the cell surface to the nucleus. Several vertebrate Notch receptors have also been discovered recently and play important roles in normal development and tumorigenesis.

Bibliography

Artavanis-Tsakonas, S., Matsuno, K., & Fortini, M. E. (1995). Notch Signaling. Science, 268(5208), 225–232.

Authors 3
  1. Spyros Artavanis-Tsakonas (first)
  2. Kenji Matsuno (additional)
  3. Mark E. Fortini (additional)
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Dates
Type When
Created 18 years, 9 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited 1 year, 7 months ago (Jan. 14, 2024, 11:24 p.m.)
Indexed 2 weeks ago (Aug. 7, 2025, 4:39 p.m.)
Issued 30 years, 4 months ago (April 14, 1995)
Published 30 years, 4 months ago (April 14, 1995)
Published Print 30 years, 4 months ago (April 14, 1995)
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@article{Artavanis_Tsakonas_1995, title={Notch Signaling}, volume={268}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7716513}, DOI={10.1126/science.7716513}, number={5208}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Artavanis-Tsakonas, Spyros and Matsuno, Kenji and Fortini, Mark E.}, year={1995}, month=apr, pages={225–232} }