DOI: 10.1126/science.7716512. Protein Lipidation in Cell Signaling

10.1126/science.7716512

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The ability of cells to communicate with and respond to their external environment is critical for their continued existence. A universal feature of this communication is that the external signal must in some way penetrate the lipid bilayer surrounding the cell. In most cases of such signal acquisition, the signaling entity itself does not directly enter the cell but rather transmits its information to specific proteins present on the surface of the cell membrane. These proteins then communicate with additional proteins associated with the intracellular face of the membrane. Membrane localization and function of many of these proteins are dependent on their covalent modification by specific lipids, and it is the processes involved that form the focus of this article.

Bibliography

Casey, P. J. (1995). Protein Lipidation in Cell Signaling. Science, 268(5208), 221â225.

Authors 1

Patrick J. Casey (first)

References 65 Referenced 623

AMES, J.B., SECONDARY STRUCTURE OF MYRISTOYLATED RECOVERIN DETERMINED BY 3-DIMENSIONAL HETERONUCLEAR NMR - IMPLICATIONS FOR THE CALCIUM MYRISTOYL SWITCH, BIOCHEMISTRY 33: 10743 (1994). (10.1021/bi00201a023) / BIOCHEMISTRY (1994)
ANDERSON, R.G., SEMIN IMMUNOL 6: 89 (1994). (10.1006/smim.1994.1013) / SEMIN IMMUNOL (1994)
BIGAY, J, ROLES OF LIPID MODIFICATIONS OF TRANSDUCIN SUBUNITS IN THEIR GDP-DEPENDENT ASSOCIATION AND MEMBRANE-BINDING, BIOCHEMISTRY 33: 14081 (1994). (10.1021/bi00251a017) / BIOCHEMISTRY (1994)
BIZZOZERO, O.A., OVERVIEW - PROTEIN PALMITOYLATION IN THE NERVOUS-SYSTEM - CURRENT VIEWS AND UNSOLVED PROBLEMS, NEUROCHEMICAL RESEARCH 19: 923 (1994). (10.1007/BF00968702) / NEUROCHEMICAL RESEARCH (1994)
10.1038/366643a0
BROWN, D, THE TYROSINE KINASE CONNECTION - HOW GPI-ANCHORED PROTEINS ACTIVATE T-CELLS, CURRENT OPINION IN IMMUNOLOGY 5: 349 (1993). (10.1016/0952-7915(93)90052-T) / CURRENT OPINION IN IMMUNOLOGY (1993)
10.1016/0092-8674(93)90323-I
10.1126/science.2648572
CAMP, L.A., MOLECULAR-CLONING AND EXPRESSION OF PALMITOYL-PROTEIN THIOESTERASE, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 23212 (1994). (10.1016/S0021-9258(17)31641-1) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
CASEY, P.J., LIPID MODIFICATIONS OF G-PROTEINS, CURRENT OPINION IN CELL BIOLOGY 6: 219 (1994). (10.1016/0955-0674(94)90139-2) / CURRENT OPINION IN CELL BIOLOGY (1994)
CHEN, W.J., CDNA CLONING AND EXPRESSION OF THE PEPTIDE-BINDING BETA-SUBUNIT OF RAT P21RAS FARNESYLTRANSFERASE, THE COUNTERPART OF YEAST DPR1/RAM1, CELL 66: 327 (1991). (10.1016/0092-8674(91)90622-6) / CELL (1991)
CINEK, T, THE NATURE OF LARGE NONCOVALENT COMPLEXES CONTAINING GLYCOSYL-PHOSPHATIDYLINOSITOL-ANCHORED MEMBRANE-GLYCOPROTEINS AND PROTEIN TYROSINE KINASES, JOURNAL OF IMMUNOLOGY 149: 2262 (1992). (10.4049/jimmunol.149.7.2262) / JOURNAL OF IMMUNOLOGY (1992)
CLARKE, S, PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUES, ANNUAL REVIEW OF BIOCHEMISTRY 61: 355 (1992). (10.1146/annurev.bi.61.070192.002035) / ANNUAL REVIEW OF BIOCHEMISTRY (1992)
COHEN, G.B., MODULAR BINDING DOMAINS IN SIGNAL-TRANSDUCTION PROTEINS, CELL 80: 237 (1995). (10.1016/0092-8674(95)90406-9) / CELL (1995)
COX, A.D., THE CAAX PEPTIDOMIMETIC COMPOUND B581 SPECIFICALLY BLOCKS FARNESYLATED, BUT NOT GERANYLGERANYLATED OR MYRISTYLATED, ONCOGENIC RAS SIGNALING AND TRANSFORMATION, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 19203 (1994). (10.1016/S0021-9258(17)32153-1) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
DEGTYAREV, M.Y., PALMITOYLATION OF A G-PROTEIN ALPHA(I) SUBUNIT REQUIRES MEMBRANE LOCALIZATION NOT MYRISTOYLATION, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 30898 (1994). (10.1016/S0021-9258(18)47366-8) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
10.1126/science.8430337
ENGLUND, P.T., THE STRUCTURE AND BIOSYNTHESIS OF GLYCOSYL PHOSPHATIDYLINOSITOL PROTEIN ANCHORS, ANNUAL REVIEW OF BIOCHEMISTRY 62: 121 (1993). (10.1146/annurev.bi.62.070193.001005) / ANNUAL REVIEW OF BIOCHEMISTRY (1993)
FRA, A.M., DETERGENT-INSOLUBLE GLYCOLIPID MICRODOMAINS IN LYMPHOCYTES IN THE ABSENCE OF CAVEOLAE, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 30745 (1994). (10.1016/S0021-9258(18)47340-1) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
FUKADA, Y, EFFECTS OF CARBOXYL METHYLATION OF PHOTORECEPTOR G-PROTEIN GAMMA-SUBUNIT IN VISUAL TRANSDUCTION, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 5163 (1994). (10.1016/S0021-9258(17)37670-6) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
GIBBS, J.B., FARNESYLTRANSFERASE INHIBITORS - RAS RESEARCH YIELDS A POTENTIAL CANCER THERAPEUTIC, CELL 77: 175 (1994). (10.1016/0092-8674(94)90308-5) / CELL (1994)
GLOMSET, J.A., PRENYL PROTEINS IN EUKARYOTIC CELLS - A NEW TYPE OF MEMBRANE ANCHOR, TRENDS IN BIOCHEMICAL SCIENCES 15: 139 (1990). (10.1016/0968-0004(90)90213-U) / TRENDS IN BIOCHEMICAL SCIENCES (1990)
HAGA, K, ACTIVATION BY G-PROTEIN BETA-GAMMA-SUBUNITS OF AGONIST-DEPENDENT OR LIGHT-DEPENDENT PHOSPHORYLATION OF MUSCARINIC ACETYLCHOLINE-RECEPTORS AND RHODOPSIN, JOURNAL OF BIOLOGICAL CHEMISTRY 267: 2222 (1992). (10.1016/S0021-9258(18)45865-6) / JOURNAL OF BIOLOGICAL CHEMISTRY (1992)
HALLAK, H, COVALENT BINDING OF ARACHIDONATE TO G-PROTEIN ALPHA-SUBUNITS OF HUMAN PLATELETS, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 4713 (1994). (10.1016/S0021-9258(17)37602-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
HANCOCK, J.F., A CAAX OR A CAAL MOTIF AND A 2ND SIGNAL ARE SUFFICIENT FOR PLASMA-MEMBRANE TARGETING OF RAS PROTEINS, EMBO JOURNAL 10: 4033 (1991). (10.1002/j.1460-2075.1991.tb04979.x) / EMBO JOURNAL (1991)
HIGGINS, J.B., IN-VITRO PROCESSING OF RECOMBINANT G-PROTEIN GAMMA-SUBUNITS - REQUIREMENTS FOR ASSEMBLY OF AN ACTIVE BETA-GAMMA COMPLEX, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 9067 (1994). (10.1016/S0021-9258(17)37077-1) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
10.1016/S0021-9258(20)80439-6
10.1126/science.8316834
JOHNSON, D.R., GENETIC AND BIOCHEMICAL-STUDIES OF PROTEIN N-MYRISTOYLATION, ANNUAL REVIEW OF BIOCHEMISTRY 63: 869 (1994). (10.1146/annurev.bi.63.070194.004253) / ANNUAL REVIEW OF BIOCHEMISTRY (1994)
JOHNSON, R.S., HETEROGENEOUS N-ACYLATION IS A TISSUE-SPECIFIC AND SPECIES-SPECIFIC POSTTRANSLATIONAL MODIFICATION, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 21067 (1994). (10.1016/S0021-9258(17)31930-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
KAHN, R.A., ARF SIGNALING - A POTENTIAL ROLE FOR PHOSPHOLIPASE-D IN MEMBRANE TRAFFIC, CELL 75: 1045 (1993). (10.1016/0092-8674(93)90314-G) / CELL (1993)
KAWATE, N, PALMITOYLATION OF LUTEINIZING-HORMONE HUMAN CHORIOGONADOTROPIN RECEPTORS IN TRANSFECTED CELLS - ABOLITION OF PALMITOYLATION BY MUTATION OF CYS-621 AND CYS-622 RESIDUES IN THE CYTOPLASMIC TAIL INCREASES LIGAND-INDUCED INTERNALIZATION OF THE RECEPTOR, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 30651 (1994). (10.1016/S0021-9258(18)43863-X) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
KOHL, N.E., PROTEIN FARNESYLTRANSFERASE INHIBITORS BLOCK THE GROWTH OF RAS-DEPENDENT TUMORS IN NUDE-MICE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 9141 (1994). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1994)
Kokame, K., Nature 359:749 (1992). (10.1038/359749a0) / Nature (1992)
LEIDICH, S.D., A CONDITIONALLY LETHAL YEAST MUTANT BLOCKED AT THE FIRST STEP IN GLYCOSYL PHOSPHATIDYLINOSITOL ANCHOR SYNTHESIS, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 10193 (1994). (10.1016/S0021-9258(17)34042-5) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
LINDER, M.E., LIPID MODIFICATIONS OF G-PROTEIN SUBUNITS - MYRISTOYLATION OF G-ALPHA INCREASES ITS AFFINITY FOR BETA-GAMMA, JOURNAL OF BIOLOGICAL CHEMISTRY 266: 4654 (1991). (10.1016/S0021-9258(20)64372-1) / JOURNAL OF BIOLOGICAL CHEMISTRY (1991)
LISANTI, M.P., CHARACTERIZATION OF CAVEOLIN-RICH MEMBRANE DOMAINS ISOLATED FROM AN ENDOTHELIAL-RICH SOURCE - IMPLICATIONS FOR HUMAN-DISEASE, JOURNAL OF CELL BIOLOGY 126: 111 (1994). (10.1083/jcb.126.1.111) / JOURNAL OF CELL BIOLOGY (1994)
MANENTI, S, DEMYRISTOYLATION OF THE MAJOR SUBSTRATE OF PROTEIN-KINASE-C (MARCKS) BY THE CYTOPLASMIC FRACTION OF BRAIN SYNAPTOSOMES, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 8309 (1994). (10.1016/S0021-9258(17)37194-6) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
10.1126/science.8456312
10.1126/science.7680492
MOUILLAC, B, AGONIST-MODULATED PALMITOYLATION OF BETA-2-ADRENERGIC RECEPTOR IN SF9 CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 267: 21733 (1992). (10.1016/S0021-9258(19)36673-6) / JOURNAL OF BIOLOGICAL CHEMISTRY (1992)
MUNTZ, K.H., INFLUENCE OF GAMMA SUBUNIT PRENYLATION ON ASSOCIATION OF GUANINE NUCLEOTIDE-BINDING REGULATORY PROTEINS WITH MEMBRANES, MOLECULAR BIOLOGY OF THE CELL 3: 49 (1992). (10.1091/mbc.3.1.49) / MOLECULAR BIOLOGY OF THE CELL (1992)
MUSHA, T, THE GERANYLGERANYL MOIETY BUT NOT THE METHYL MOIETY OF THE SMG-25A RAB3A PROTEIN IS ESSENTIAL FOR THE INTERACTIONS WITH MEMBRANE AND ITS INHIBITORY GDP GTP EXCHANGE PROTEIN, JOURNAL OF BIOLOGICAL CHEMISTRY 267: 9821 (1992). (10.1016/S0021-9258(19)50167-3) / JOURNAL OF BIOLOGICAL CHEMISTRY (1992)
10.1016/0092-8674(95)90407-7
10.1016/0092-8674(93)90478-9
10.1126/science.1096303
PORFIRI, E, PRENYLATION OF RAS PROTEINS IS REQUIRED FOR EFFICIENT HSOS1-PROMOTED GUANINE-NUCLEOTIDE EXCHANGE, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 22672 (1994). (10.1016/S0021-9258(17)31698-8) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
QUESNEL, S, CYSTEINE-CONTAINING PEPTIDE SEQUENCES EXHIBIT FACILE UNCATALYZED TRANSACYLATION AND ACYL-COA-DEPENDENT ACYLATION AT THE LIPID BILAYER INTERFACE, BIOCHEMISTRY 33: 13340 (1994). (10.1021/bi00249a021) / BIOCHEMISTRY (1994)
RESH, M.D., MYRISTYLATION AND PALMITYLATION OF SRC FAMILY MEMBERS - THE FATS OF THE MATTER, CELL 76: 411 (1994). (10.1016/0092-8674(94)90104-X) / CELL (1994)
RODGERS, W, SIGNALS DETERMINING PROTEIN-TYROSINE KINASE AND GLYCOSYL-PHOSPHATIDYLINOSITOL-ANCHORED PROTEIN TARGETING TO A GLYCOLIPID-ENRICHED MEMBRANE-FRACTION, MOLECULAR AND CELLULAR BIOLOGY 14: 5384 (1994). / MOLECULAR AND CELLULAR BIOLOGY (1994)
Schafer, W. R., Annual Review of Genetics 265: 209 (1992). / Annual Review of Genetics (1992)
Schlesinger, M. J., Lipid Modifications of Proteins: 1 (1993). / Lipid Modifications of Proteins (1993)
SCHROEDER, R, INTERACTIONS BETWEEN SATURATED ACYL CHAINS CONFER DETERGENT RESISTANCE ON LIPIDS AND GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)-ANCHORED PROTEINS - GPI-ANCHORED PROTEINS IN LIPOSOMES AND CELLS SHOW SIMILAR BEHAVIOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 12130 (1994). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1994)
SEABRA, M.C., RAB GERANYLGERANYL TRANSFERASE - A MULTISUBUNIT ENZYME THAT PRENYLATES GTP-BINDING PROTEINS TERMINATING IN CYS-X-CYS OR CYS-CYS, JOURNAL OF BIOLOGICAL CHEMISTRY 267: 14497 (1992). (10.1016/S0021-9258(19)49740-8) / JOURNAL OF BIOLOGICAL CHEMISTRY (1992)
10.1126/science.8380507
SHENOYSCARIA, A.M., CYSTEINE(3) OF SRC FAMILY PROTEIN-TYROSINE KINASES DETERMINES PALMITOYLATION AND LOCALIZATION IN CAVEOLAE, JOURNAL OF CELL BIOLOGY 126: 353 (1994). (10.1083/jcb.126.2.353) / JOURNAL OF CELL BIOLOGY (1994)
SHENOYSCARIA, A.M., PALMITYLATION OF AN AMINO-TERMINAL CYSTEINE MOTIF OF PROTEIN-TYROSINE KINASES P56LCK AND P59FYN MEDIATES INTERACTION WITH GLYCOSYL-PHOSPHATIDYLINOSITOL-ANCHORED PROTEINS, MOLECULAR AND CELLULAR BIOLOGY 13: 6385 (1993). / MOLECULAR AND CELLULAR BIOLOGY (1993)
10.1021/bi00176a034
STOFFEL, R.H., PALMITOYLATION OF G-PROTEIN-COUPLED RECEPTOR KINASE, GRK6 - LIPID MODIFICATION DIVERSITY IN THE GRK FAMILY, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 27791 (1994). (10.1016/S0021-9258(18)46852-4) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
TAMANOI, F, INHIBITORS OF RAS FARNESYLTRANSFERASES, TRENDS IN BIOCHEMICAL SCIENCES 18: 349 (1993). (10.1016/0968-0004(93)90072-U) / TRENDS IN BIOCHEMICAL SCIENCES (1993)
VIDUGIRIENE, J, THE GPI ANCHOR OF CELL-SURFACE PROTEINS IS SYNTHESIZED ON THE CYTOPLASMIC FACE OF THE ENDOPLASMIC-RETICULUM, JOURNAL OF CELL BIOLOGY 127: 333 (1994). (10.1083/jcb.127.2.333) / JOURNAL OF CELL BIOLOGY (1994)
WEDEGAERTNER, P.B., PALMITOYLATION IS REQUIRED FOR SIGNALING FUNCTIONS AND MEMBRANE ATTACHMENT OF G(Q)ALPHA AND G(S)ALPHA, JOURNAL OF BIOLOGICAL CHEMISTRY 268: 25001 (1993). (10.1016/S0021-9258(19)74563-3) / JOURNAL OF BIOLOGICAL CHEMISTRY (1993)
WEDEGAERTNER, P.B., LIPID MODIFICATIONS OF TRIMERIC G-PROTEINS, JOURNAL OF BIOLOGICAL CHEMISTRY 270: 503 (1995). (10.1074/jbc.270.2.503) / JOURNAL OF BIOLOGICAL CHEMISTRY (1995)
ZHANG, F.L., CDNA CLONING AND EXPRESSION OF RAT AND HUMAN PROTEIN GERANYLGERANYLTRANSFERASE TYPE-I, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 3175 (1994). (10.1016/S0021-9258(17)41845-X) / JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
ZHENG, J.H., CRYSTAL-STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN-KINASE REVEAL OPEN AND CLOSED CONFORMATIONS, PROTEIN SCIENCE 2: 1559 (1993). (10.1002/pro.5560021003) / PROTEIN SCIENCE (1993)

Dates

Type	When
Created	18 years, 9 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:25 p.m.)
Indexed	2 weeks, 2 days ago (Aug. 7, 2025, 4:55 a.m.)
Issued	30 years, 4 months ago (April 14, 1995)
Published	30 years, 4 months ago (April 14, 1995)
Published Print	30 years, 4 months ago (April 14, 1995)

Funders 0

None

BibTeX

@article{Casey_1995, title={Protein Lipidation in Cell Signaling}, volume={268}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7716512}, DOI={10.1126/science.7716512}, number={5208}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Casey, Patrick J.}, year={1995}, month=apr, pages={221–225} }

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      "key": "e_1_2_1_33_1",
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      "journal-title": "Nature"
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      "DOI": "10.1016/S0021-9258(18)46852-4",
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