DOI: 10.1126/science.7694370. Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4

Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4

10.1126/science.7694370

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Interleukin-4 (IL-4) is an immunoregulatory cytokine produced by activated T lymphocytes to promote the growth and differentiation of cells that participate in immune defense. This study demonstrates the rapid activation of a specific DNA binding factor by IL-4. The IL-4 nuclear-activated factor (IL-4 NAF) appeared within minutes of IL-4 stimulation and recognized a specific DNA sequence found in the promoters of IL-4-responsive genes. Activation of this putative transcription factor required tyrosine phosphorylation, and antibodies specific for phosphotyrosine recognize the IL-4 NAF-DNA complex. Thus, IL-4 appears to transduce a signal to the nucleus through tyrosine phosphorylation of a latent DNA binding factor.

Bibliography

Kotanides, H., & Reich, N. C. (1993). Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4. Science, 262(5137), 1265â1267.

Authors 2

Helen Kotanides (first)
Nancy C. Reich (additional)

References 40 Referenced 183

BENOIST, C, REGULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II GENES - X, Y AND OTHER LETTERS OF THE ALPHABET, ANNUAL REVIEW OF IMMUNOLOGY 8: 681 (1990). (10.1146/annurev.iy.08.040190.003341) / ANNUAL REVIEW OF IMMUNOLOGY (1990)
10.1126/science.3144043
CAO, H, DIFFERENTIAL REGULATION OF CLASS-II MHC DETERMINANTS ON MACROPHAGES BY IFN-GAMMA AND IL-4, JOURNAL OF IMMUNOLOGY 143: 3524 (1989). (10.4049/jimmunol.143.11.3524) / JOURNAL OF IMMUNOLOGY (1989)
CONRAD, D.H., FC-EPSILON-RII/CD23 - THE LOW AFFINITY RECEPTOR FOR IGE, ANNUAL REVIEW OF IMMUNOLOGY 8: 623 (1990). (10.1146/annurev.iy.08.040190.003203) / ANNUAL REVIEW OF IMMUNOLOGY (1990)
DEFRANCE, T, HUMAN RECOMBINANT INTERLEUKIN-4 INDUCES FC-EPSILON RECEPTORS (CD23) ON NORMAL HUMAN LYMPHOCYTES-B, JOURNAL OF EXPERIMENTAL MEDICINE 165: 1459 (1987). (10.1084/jem.165.6.1459) / JOURNAL OF EXPERIMENTAL MEDICINE (1987)
10.1146/annurev.iy.08.040190.001511
10.1016/0092-8674(92)90106-M
GERONDAKIS, S, STRUCTURE AND EXPRESSION OF MURINE GERM-LINE IMMUNOGLOBULIN-EPSILON HEAVY-CHAIN TRANSCRIPTS INDUCED BY INTERLEUKIN-4, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 1581 (1990). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1990)
GILMOUR K.C. unpublished data.
GLIMCHER, L.H., SEQUENCES AND FACTORS - A GUIDE TO MHC CLASS-II TRANSCRIPTION, ANNUAL REVIEW OF IMMUNOLOGY 10: 13 (1992). (10.1146/annurev.iy.10.040192.000305) / ANNUAL REVIEW OF IMMUNOLOGY (1992)
GUTCH, M.J., TYROSINE PHOSPHORYLATION IS REQUIRED FOR ACTIVATION OF AN ALPHA-INTERFERON-STIMULATED TRANSCRIPTION FACTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89: 11411 (1992). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1992)
GUTCH M.J. unpublished data.
IDZERDA, R.L., HUMAN INTERLEUKIN-4 RECEPTOR CONFERS BIOLOGICAL RESPONSIVENESS AND DEFINES A NOVEL RECEPTOR SUPERFAMILY, JOURNAL OF EXPERIMENTAL MEDICINE 171: 861 (1990). (10.1084/jem.171.3.861) / JOURNAL OF EXPERIMENTAL MEDICINE (1990)
IGARASHI, K, IN-VITRO ACTIVATION OF A TRANSCRIPTION FACTOR BY GAMMA-INTERFERON REQUIRES A MEMBRANE-ASSOCIATED TYROSINE KINASE AND IS MIMICKED BY VANADATE, MOLECULAR AND CELLULAR BIOLOGY 13: 3984 (1993). / MOLECULAR AND CELLULAR BIOLOGY (1993)
ILLGES, H, DNA-BINDING SITES 5' OF THE IGG1 SWITCH REGION COMPRISING IL4 INDUCIBILITY AND B-CELL SPECIFICITY, MOLECULAR IMMUNOLOGY 29: 1265 (1992). (10.1016/0161-5890(92)90063-4) / MOLECULAR IMMUNOLOGY (1992)
ISFORT, R.J., GROWTH FACTORS 2: 213 (1990). (10.3109/08977199009071507) / GROWTH FACTORS (1990)
KIKUTANI, H, MOLECULAR-STRUCTURE OF HUMAN-LYMPHOCYTE RECEPTOR FOR IMMUNOGLOBULIN-E, CELL 47: 657 (1986). (10.1016/0092-8674(86)90508-8) / CELL (1986)
KOTANIDES H unpublished data.
LEW, D.J., OVERLAPPING ELEMENTS IN THE GUANYLATE-BINDING PROTEIN GENE PROMOTER MEDIATE TRANSCRIPTIONAL INDUCTION BY ALPHA AND GAMMA INTERFERONS, MOLECULAR AND CELLULAR BIOLOGY 11: 182 (1991). / MOLECULAR AND CELLULAR BIOLOGY (1991)
MCGARVIE, G.M., APPEARANCE OF A NOVEL PLASMA-MEMBRANE PHOSPHOPROTEIN FOLLOWING CULTURE OF RESTING MURINE B-LYMPHOCYTES WITH RECOMBINANT INTERLEUKIN-4, IMMUNOLOGY LETTERS 22: 221 (1989). (10.1016/0165-2478(89)90195-8) / IMMUNOLOGY LETTERS (1989)
MIRESLUIS, A.R., INTERLEUKIN-4 PROLIFERATIVE SIGNAL TRANSDUCTION INVOLVES THE ACTIVATION OF A TYROSINE-SPECIFIC PHOSPHATASE AND THE DEPHOSPHORYLATION OF AN 80-KDA PROTEIN, JOURNAL OF BIOLOGICAL CHEMISTRY 266: 18113 (1991). (10.1016/S0021-9258(18)55243-1) / JOURNAL OF BIOLOGICAL CHEMISTRY (1991)
MOND, J.J., J IMMUNOL 137: 353 (1986). (10.4049/jimmunol.137.1.353) / J IMMUNOL (1986)
MORLA, A.O., HEMATOPOIETIC GROWTH-FACTORS ACTIVATE THE TYROSINE PHOSPHORYLATION OF DISTINCT SETS OF PROTEINS IN INTERLEUKIN-3-DEPENDENT MURINE CELL-LINES, MOLECULAR AND CELLULAR BIOLOGY 8: 2214 (1988). / MOLECULAR AND CELLULAR BIOLOGY (1988)
PAUL, W.E., INTERLEUKIN-4 - A PROTOTYPIC IMMUNOREGULATORY LYMPHOKINE, BLOOD 77: 1859 (1991). (10.1182/blood.V77.9.1859.1859) / BLOOD (1991)
PEARSE, R.N., INTERFERON-GAMMA-INDUCED TRANSCRIPTION OF THE HIGH-AFFINITY FC RECEPTOR FOR IGG REQUIRES ASSEMBLY OF A COMPLEX THAT INCLUDES THE 91-KDA SUBUNIT OF TRANSCRIPTION FACTOR ISGF3, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 4314 (1993). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1993)
PEREZ, C, 2 CIS-DNA ELEMENTS INVOLVED IN MYELOID-CELL-SPECIFIC EXPRESSION AND GAMMA-INTERFERON (IFN-GAMMA) ACTIVATION OF THE HUMAN HIGH-AFFINITY FC-GAMMA RECEPTOR GENE - A NOVEL IFN REGULATORY MECHANISM, MOLECULAR AND CELLULAR BIOLOGY 13: 2182 (1993). / MOLECULAR AND CELLULAR BIOLOGY (1993)
PURKERSON, J, A 2-SIGNAL MODEL FOR REGULATION OF IMMUNOGLOBULIN ISOTYPE SWITCHING, FASEB JOURNAL 6: 3245 (1992). (10.1096/fasebj.6.14.1385241) / FASEB JOURNAL (1992)
REICH, N.C., EVIDENCE FOR INVOLVEMENT OF PROTEIN-KINASE-C IN THE CELLULAR-RESPONSE TO INTERFERON-ALPHA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 8761 (1990). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1990)
ROTHMAN, P, IDENTIFICATION OF A CONSERVED LIPOPOLYSACCHARIDE-PLUS-INTERLEUKIN-4-RESPONSIVE ELEMENT LOCATED AT THE PROMOTER OF GERM LINE EPSILON-TRANSCRIPTS, MOLECULAR AND CELLULAR BIOLOGY 11: 5551 (1991). / MOLECULAR AND CELLULAR BIOLOGY (1991)
SARFATI, M, EXPRESSION, REGULATION AND FUNCTION OF HUMAN FC-EPSILON-RII (CD23) ANTIGEN, IMMUNOLOGIC RESEARCH 11: 260 (1992). (10.1007/BF02919132) / IMMUNOLOGIC RESEARCH (1992)
10.1126/science.1496401
10.1126/science.1281555
10.1126/science.3107127
STUART, P.M., INDUCTION OF CLASS-I AND CLASS-II MHC ANTIGEN EXPRESSION ON MURINE BONE MARROW-DERIVED MACROPHAGES BY IL-4 (B-CELL STIMULATORY FACTOR-I), JOURNAL OF IMMUNOLOGY 140: 1542 (1988). (10.4049/jimmunol.140.5.1542) / JOURNAL OF IMMUNOLOGY (1988)
SUTER, U, EXPRESSION OF HUMAN-LYMPHOCYTE IGE RECEPTOR (FC-EPSILON-RII CD23) - IDENTIFICATION OF THE FC-EPSILON-RIIA PROMOTER AND ITS FUNCTIONAL-ANALYSIS IN LYMPHOCYTE-B, JOURNAL OF IMMUNOLOGY 143: 3087 (1989). (10.4049/jimmunol.143.9.3087) / JOURNAL OF IMMUNOLOGY (1989)
WANG, L.M., IL-4 ACTIVATES A DISTINCT SIGNAL TRANSDUCTION CASCADE FROM IL-3 IN FACTOR-DEPENDENT MYELOID CELLS, EMBO JOURNAL 11: 4899 (1992). (10.1002/j.1460-2075.1992.tb05596.x) / EMBO JOURNAL (1992)
WANG, L.M., COMMON ELEMENTS IN INTERLEUKIN-4 AND INSULIN SIGNALING PATHWAYS IN FACTOR-DEPENDENT HEMATOPOIETIC-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 4032 (1993). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1993)
XU, M.Z., REGULATION OF TRANSCRIPTION OF IMMUNOGLOBULIN GERM-LINE GAMMA-1 RNA - ANALYSIS OF THE PROMOTER ENHANCER, EMBO JOURNAL 11: 145 (1992). (10.1002/j.1460-2075.1992.tb05037.x) / EMBO JOURNAL (1992)
YANG, Q, CLONING AND EXPRESSION OF PTP-PEST - A NOVEL, HUMAN, NONTRANSMEMBRANE PROTEIN TYROSINE PHOSPHATASE, JOURNAL OF BIOLOGICAL CHEMISTRY 268: 6622 (1993). (10.1016/S0021-9258(18)53296-8) / JOURNAL OF BIOLOGICAL CHEMISTRY (1993)
YOKOTA, A, 2 SPECIES OF HUMAN FC-EPSILON RECEPTOR-II (FC-EPSILON-RII/CD23) - TISSUE-SPECIFIC AND IL-4-SPECIFIC REGULATION OF GENE-EXPRESSION, CELL 55: 611 (1988). (10.1016/0092-8674(88)90219-X) / CELL (1988)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:05 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:35 p.m.)
Indexed	4 months, 3 weeks ago (March 31, 2025, 12:45 p.m.)
Issued	31 years, 9 months ago (Nov. 19, 1993)
Published	31 years, 9 months ago (Nov. 19, 1993)
Published Print	31 years, 9 months ago (Nov. 19, 1993)

Funders 0

None

BibTeX

@article{Kotanides_1993, title={Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4}, volume={262}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7694370}, DOI={10.1126/science.7694370}, number={5137}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Kotanides, Helen and Reich, Nancy C.}, year={1993}, month=nov, pages={1265–1267} }

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