DOI: 10.1126/science.7688481. T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

10.1126/science.7688481

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The ζ subunit of the T cell antigen receptor complex is required for targeting nascent receptor complexes to the cell surface and for receptor-mediated signal transduction. To examine the significance of the ζ subunit in T cell development, mice deficient for ζ expression were generated by gene targeting. These ζ -/- mice had few CD4 + CD8 + thymocytes, and the generation of CD4 + and CD8 + single positive T cells was impaired but not completely abrogated. Peripheral T cells were present but were unusual in that they expressed small amounts of CD5 and few T cell receptors. Thus, ζ chain expression influences thymocyte differentiation but is not absolutely required for the generation of single positive T cells.

Bibliography

Love, P. E., Shores, E. W., Johnson, M. D., Tremblay, M. L., Lee, E. J., Grinberg, A., Huang, S. P., Singer, A., & Westphal, H. (1993). T Cell Development in Mice that Lack the Î¶ Chain of the T Cell Antigen Receptor Complex. Science, 261(5123), 918â921.

Authors 9

Paul E. Love (first)
Elizabeth W. Shores (additional)
Mark D. Johnson (additional)
Michel L. Tremblay (additional)
Eric J. Lee (additional)
Alexander Grinberg (additional)
Sing Ping Huang (additional)
Alfred Singer (additional)
Heiner Westphal (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:05 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 12:17 a.m.)
Indexed	4 weeks ago (Aug. 7, 2025, 4:26 p.m.)
Issued	32 years ago (Aug. 13, 1993)
Published	32 years ago (Aug. 13, 1993)
Published Print	32 years ago (Aug. 13, 1993)

Funders 0

None

BibTeX

@article{Love_1993, title={T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex}, volume={261}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7688481}, DOI={10.1126/science.7688481}, number={5123}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Love, Paul E. and Shores, Elizabeth W. and Johnson, Mark D. and Tremblay, Michel L. and Lee, Eric J. and Grinberg, Alexander and Huang, Sing Ping and Singer, Alfred and Westphal, Heiner}, year={1993}, month=aug, pages={918–921} }

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