DOI: 10.1126/science.7681220. An Osmosensing Signal Transduction Pathway in Yeast

An Osmosensing Signal Transduction Pathway in Yeast

10.1126/science.7681220

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Yeast genes were isolated that are required for restoring the osmotic gradient across the cell membrane in response to increased external osmolarity. Two of these genes, HOG1 and PBS2 , encode members of the mitogen-activated protein kinase (MAP kinase) and MAP kinase kinase gene families, respectively. MAP kinases are activated by extracellular ligands such as growth factors and function as intermediate kinases in protein phosphorylation cascades. A rapid, PBS2 -dependent tyrosine phosphorylation of HOG1 protein occurred in response to increases in extracellular osmolarity. These data define a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.

Bibliography

Brewster, J. L., de Valoir, T., Dwyer, N. D., Winter, E., & Gustin, M. C. (1993). An Osmosensing Signal Transduction Pathway in Yeast. Science, 259(5102), 1760â1763.

Authors 5

Jay L. Brewster (first)
Tamsen de Valoir (additional)
Noelle D. Dwyer (additional)
Edward Winter (additional)
Michael C. Gustin (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:05 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 12:30 a.m.)
Indexed	3 days, 3 hours ago (Aug. 23, 2025, 9:20 p.m.)
Issued	32 years, 5 months ago (March 19, 1993)
Published	32 years, 5 months ago (March 19, 1993)
Published Print	32 years, 5 months ago (March 19, 1993)

Funders 0

None

BibTeX

@article{Brewster_1993, title={An Osmosensing Signal Transduction Pathway in Yeast}, volume={259}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7681220}, DOI={10.1126/science.7681220}, number={5102}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Brewster, Jay L. and de Valoir, Tamsen and Dwyer, Noelle D. and Winter, Edward and Gustin, Michael C.}, year={1993}, month=mar, pages={1760–1763} }

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