DOI: 10.1126/science.7638621. A Familial Alzheimer's Disease Locus on Chromosome 1

A Familial Alzheimer's Disease Locus on Chromosome 1

10.1126/science.7638621

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The Volga German kindreds are a group of seven related families with autosomal dominant early-onset Alzheimer's disease (AD). Linkage to known AD-related loci on chromosomes 21 and 14 has been excluded. Significant evidence for linkage to AD in these families was obtained with D1S479 and there was also positive evidence for linkage with other markers in the region. A 112-base pair allele of D1S479 co-segregated with the disease in five of seven families, which is consistent with a common genetic founder. This study demonstrates the presence of an AD locus on chromosome 1q31-42.

Bibliography

Levy-Lahad, E., Wijsman, E. M., Nemens, E., Anderson, L., Goddard, K. A. B., Weber, J. L., Bird, T. D., & Schellenberg, G. D. (1995). A Familial Alzheimerâs Disease Locus on Chromosome 1. Science, 269(5226), 970â973.

Authors 8

Ephrat Levy-Lahad (first)
Ellen M. Wijsman (additional)
Ellen Nemens (additional)
Leojean Anderson (additional)
Katrina A. B. Goddard (additional)
James L. Weber (additional)
Thomas D. Bird (additional)
Gerard D. Schellenberg (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:49 p.m.)
Indexed	11 hours, 38 minutes ago (Aug. 28, 2025, 8:11 a.m.)
Issued	30 years ago (Aug. 18, 1995)
Published	30 years ago (Aug. 18, 1995)
Published Print	30 years ago (Aug. 18, 1995)

Funders 0

None

BibTeX

@article{Levy_Lahad_1995, title={A Familial Alzheimer’s Disease Locus on Chromosome 1}, volume={269}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7638621}, DOI={10.1126/science.7638621}, number={5226}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Levy-Lahad, Ephrat and Wijsman, Ellen M. and Nemens, Ellen and Anderson, Leojean and Goddard, Katrina A. B. and Weber, James L. and Bird, Thomas D. and Schellenberg, Gerard D.}, year={1995}, month=aug, pages={970–973} }

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