DOI: 10.1126/science.7624793. Circuit Simulation of Genetic Networks

10.1126/science.7624793

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Genetic networks with tens to hundreds of genes are difficult to analyze with currently available techniques. Because of the many parallels in the function of these biochemically based genetic circuits and electrical circuits, a hybrid modeling approach is proposed that integrates conventional biochemical kinetic modeling within the framework of a circuit simulation. The circuit diagram of the bacteriophage lambda lysis-lysogeny decision circuit represents connectivity in signal paths of the biochemical components. A key feature of the lambda genetic circuit is that operons function as active integrated logic components and introduce signal time delays essential for the in vivo behavior of phage lambda.

Bibliography

McAdams, H. H., & Shapiro, L. (1995). Circuit Simulation of Genetic Networks. Science, 269(5224), 650â656.

Authors 2

Harley H. McAdams (first)
Lucy Shapiro (additional)

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Dates

Type	When
Created	18 years, 9 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:52 p.m.)
Indexed	3 weeks, 2 days ago (July 30, 2025, 10:41 a.m.)
Issued	30 years ago (Aug. 4, 1995)
Published	30 years ago (Aug. 4, 1995)
Published Print	30 years ago (Aug. 4, 1995)

Funders 0

None

BibTeX

@article{McAdams_1995, title={Circuit Simulation of Genetic Networks}, volume={269}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7624793}, DOI={10.1126/science.7624793}, number={5224}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={McAdams, Harley H. and Shapiro, Lucy}, year={1995}, month=aug, pages={650–656} }

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