Abstract
T cell hybridomas require the immediate-early gene NGFI-B ( nur77 ) for T cell receptor (TCR)-mediated apoptosis, a model for negative selection of self-reactive T cells. TCR-mediated death was examined in mice bearing an NGFI-B loss-of-function mutation, either by administration of antibodies to CD3 (anti-CD3) or in two well-characterized transgenic models expressing self-reactive TCRs. Both the extent and the rate of thymocyte death were unimpaired. Anti-CD3-induced death was normal in CD4 + peripheral T cells, in which death is mediated predominantly by the Fas signaling pathway. Thus, no unique requirement for NGFI-B is observed for thymic or peripheral T cell death.
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Dates
| Type | When |
|---|---|
| Created | 18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.) |
| Deposited | 1 year, 7 months ago (Jan. 14, 2024, 11:48 p.m.) |
| Indexed | 3 months, 1 week ago (May 20, 2025, 9:31 a.m.) |
| Issued | 30 years, 1 month ago (July 28, 1995) |
| Published | 30 years, 1 month ago (July 28, 1995) |
| Published Print | 30 years, 1 month ago (July 28, 1995) |
@article{Lee_1995, title={Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)}, volume={269}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7624775}, DOI={10.1126/science.7624775}, number={5223}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Lee, Stephen L. and Wesselschmidt, Robin L. and Linette, Gerald P. and Kanagawa, Osami and Russell, John H. and Milbrandt, Jeffrey}, year={1995}, month=jul, pages={532–535} }