DOI: 10.1126/science.7618088. Lack of Interferon γ Receptor β Chain and the Prevention of Interferon γ Signaling in T <sub>H</sub> 1 Cells

Lack of Interferon γ Receptor β Chain and the Prevention of Interferon γ Signaling in T H 1 Cells

10.1126/science.7618088

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The ability of interferon γ (IFN-γ) to inhibit the proliferation of type 2 T helper cells (T H 2), but not that of type 1 (T H 1) cells, suggests that helper cell subsets might differ in their activation of the IFN-γ signaling pathway. The IFN-γ-inducible signal transducing factor (STF-IFNγ) was activated in murine T H 2 but not in T H 1 cell clones, because in the latter the second chain of the IFN-γ receptor (accessory factor 1 or IFN-γRβ) was absent. Thus, T H 1 cells use receptor modification to prevent the activation of STF-IFNγ and achieve an IFN-γ-resistant state.

Bibliography

Pernis, A., Gupta, S., Gollob, K. J., Garfein, E., Coffman, R. L., Schindler, C., & Rothman, P. (1995). Lack of Interferon Î³ Receptor Î² Chain and the Prevention of Interferon Î³ Signaling in T H 1 Cells. Science, 269(5221), 245â247.

Authors 7

Alessandra Pernis (first)
Sanjay Gupta (additional)
Kenneth J. Gollob (additional)
Evan Garfein (additional)
Robert L. Coffman (additional)
Chris Schindler (additional)
Paul Rothman (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:55 p.m.)
Indexed	41 minutes ago (Sept. 2, 2025, 9:57 p.m.)
Issued	30 years, 1 month ago (July 14, 1995)
Published	30 years, 1 month ago (July 14, 1995)
Published Print	30 years, 1 month ago (July 14, 1995)

Funders 0

None

BibTeX

@article{Pernis_1995, title={Lack of Interferon γ Receptor β Chain and the Prevention of Interferon γ Signaling in T H 1 Cells}, volume={269}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7618088}, DOI={10.1126/science.7618088}, number={5221}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Pernis, Alessandra and Gupta, Sanjay and Gollob, Kenneth J. and Garfein, Evan and Coffman, Robert L. and Schindler, Chris and Rothman, Paul}, year={1995}, month=jul, pages={245–247} }

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