DOI: 10.1126/science.7569929. Jak-STAT Signaling Induced by the v- <i>abl</i> oncogene

Jak-STAT Signaling Induced by the v- abl oncogene

10.1126/science.7569929

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The effect of the v- abl oncogene of the Abelson murine leukemia virus (A-MuLV) on the Jak-STAT pathway of cytokine signal transduction was investigated. In murine pre-B lymphocytes transformed with A-MuLV, the Janus kinases (Jaks) Jak1 and Jak3 exhibited constitutive tyrosine kinase activity, and the STAT proteins (signal transducers and activators of transcription) normally activated by interleukin-4 and interleukin-7 were tyrosine-phosphorylated in the absence of these cytokines. Coimmunoprecipitation experiments revealed that in these cells v-Abl was physically associated with Jak1 and Jak3. Inactivation of v-Abl tyrosine kinase in a pre-B cell line transformed with a temperature-sensitive mutant of v- abl resulted in abrogation of constitutive Jak-STAT signaling. A direct link may exist between transformation by v- abl and cytokine signal transduction.

Bibliography

Danial, N. N., Pernis, A., & Rothman, P. B. (1995). Jak-STAT Signaling Induced by the v- abl oncogene. Science, 269(5232), 1875â1877.

Authors 3

Nika N. Danial (first)
Alessandra Pernis (additional)
Paul B. Rothman (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:45 p.m.)
Indexed	1 day, 5 hours ago (Aug. 28, 2025, 8:35 a.m.)
Issued	29 years, 11 months ago (Sept. 29, 1995)
Published	29 years, 11 months ago (Sept. 29, 1995)
Published Print	29 years, 11 months ago (Sept. 29, 1995)

Funders 0

None

BibTeX

@article{Danial_1995, title={Jak-STAT Signaling Induced by the v- abl oncogene}, volume={269}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7569929}, DOI={10.1126/science.7569929}, number={5232}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Danial, Nika N. and Pernis, Alessandra and Rothman, Paul B.}, year={1995}, month=sep, pages={1875–1877} }

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