DOI: 10.1126/science.7569903. Regulation of Hippocampal Transmitter Release During Development and Long-Term Potentiation

Regulation of Hippocampal Transmitter Release During Development and Long-Term Potentiation

10.1126/science.7569903

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Developmental changes in rat hippocampal transmitter release and synaptic plasticity were investigated. Recordings from pairs of pyramidal neurons in slices showed that an action potential in a CA3 neuron released only a single quantum of transmitter onto a CA1 neuron. Failures of synaptic transmission reflected probabilistic transmitter release. The probability of release ( P r ) was 0.9 in 4- to 8-day-old rats and decreased to less than 0.5 at 2 to 3 weeks. Long-term potentiation (LTP) in 2- to 3-week-old rats was associated with an increase in P r from a single synaptic site. The high initial P r in 4- to 8-day-old rats normally occludes the expression of LTP at this stage.

Bibliography

Bolshakov, V. Y., & Siegelbaum, S. A. (1995). Regulation of Hippocampal Transmitter Release During Development and Long-Term Potentiation. Science, 269(5231), 1730â1734.

Authors 2

Vadim Y. Bolshakov (first)
Steven A. Siegelbaum (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:38 p.m.)
Indexed	59 minutes ago (Aug. 30, 2025, 9:32 a.m.)
Issued	29 years, 11 months ago (Sept. 22, 1995)
Published	29 years, 11 months ago (Sept. 22, 1995)
Published Print	29 years, 11 months ago (Sept. 22, 1995)

Funders 0

None

BibTeX

@article{Bolshakov_1995, title={Regulation of Hippocampal Transmitter Release During Development and Long-Term Potentiation}, volume={269}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7569903}, DOI={10.1126/science.7569903}, number={5231}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Bolshakov, Vadim Y. and Siegelbaum, Steven A.}, year={1995}, month=sep, pages={1730–1734} }

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