DOI: 10.1126/science.7535476. Antigen-Specific Development of Primary and Memory T Cells in Vivo

Antigen-Specific Development of Primary and Memory T Cells in Vivo

10.1126/science.7535476

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The expansion and contraction of specific helper T cells in the draining lymph nodes of normal mice after injection with antigen was followed. T cell receptors from purified primary and memory responder cells had highly restricted junctional regions, indicating antigen-driven selection. Selection for homogeneity in the length of the third complementarity-determining region (CDR3) occurs before selection for some of the characteristic amino acids, indicating the importance of this parameter in T cell receptor recognition. Ultimately, particular T cell receptor sequences come to predominate in the secondary response and others disappear, showing the selective preservation or expansion of specific T cell clones.

Bibliography

McHeyzer-Williams, M. G., & Davis, M. M. (1995). Antigen-Specific Development of Primary and Memory T Cells in Vivo. Science, 268(5207), 106â111.

Authors 2

Michael G. McHeyzer-Williams (first)
Mark M. Davis (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:22 p.m.)
Indexed	2 months, 1 week ago (June 27, 2025, 9:45 a.m.)
Issued	30 years, 4 months ago (April 7, 1995)
Published	30 years, 4 months ago (April 7, 1995)
Published Print	30 years, 4 months ago (April 7, 1995)

Funders 0

None

BibTeX

@article{McHeyzer_Williams_1995, title={Antigen-Specific Development of Primary and Memory T Cells in Vivo}, volume={268}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7535476}, DOI={10.1126/science.7535476}, number={5207}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={McHeyzer-Williams, Michael G. and Davis, Mark M.}, year={1995}, month=apr, pages={106–111} }

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