DOI: 10.1126/science.7455704. Real-Time Color Graphics in Studies of Molecular Interactions

Real-Time Color Graphics in Studies of Molecular Interactions

10.1126/science.7455704

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Studies of the structures and interactions of large biological molecules require both coordinate data and three-dimensional visualization. Orthodox molecular models often bear a tenuous relationship to the coordinate data. In contrast, computer graphics requires that the display directly and accurately represent the data, and storage of modified configurations and recovery of original structures are simple. Software has been developed that allows real-time display of color line and surface displays of several interacting molecules, while quantitatively monitoring the stereochemistry.

Bibliography

Langridge, R., Ferrin, T. E., Kuntz, I. D., & Connolly, M. L. (1981). Real-Time Color Graphics in Studies of Molecular Interactions. Science, 211(4483), 661â666.

Authors 4

Robert Langridge (first)
Thomas E. Ferrin (additional)
Irwin D. Kuntz (additional)
Michael L. Connolly (additional)

References 28 Referenced 193

American Chemical Society Burger Award Symposium Houston Texas 26 March (1980).
ARTYMIUK, P.J., CRYSTALLOGRAPHIC STUDIES OF THE DYNAMIC PROPERTIES OF LYSOZYME, NATURE 280: 563 (1979). (10.1038/280563a0) / NATURE (1979)
BERNSTEIN, F.C., PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES, JOURNAL OF MOLECULAR BIOLOGY 112: 535 (1977). (10.1016/S0022-2836(77)80200-3) / JOURNAL OF MOLECULAR BIOLOGY (1977)
Connolly M. L. in preparation.
Diamond R. BILDER: An Interactive Graphics Program for Biopolymers User's Guide (1979).
FELDMANN, R.J., DESIGN OF COMPUTING SYSTEMS FOR MOLECULAR MODELING, ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING 5: 477 (1976). (10.1146/annurev.bb.05.060176.002401) / ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING (1976)
FELDMANN, R.J., INTERACTIVE COMPUTER SURFACE GRAPHICS APPROACH TO STUDY OF ACTIVE-SITE OF BOVINE TRYPSIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75: 5409 (1978). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1978)
FERRIN, T.E., COMPUT GRAPH 13: 320 (1980). (10.1145/988500.988508) / COMPUT GRAPH (1980)
10.1038/280558a0
GREER, J, MACROMOLECULAR SHAPE AND SURFACE MAPS BY SOLVENT EXCLUSION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75: 303 (1978). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1978)
HUBER, R, STRUCTURE OF COMPLEX FORMED BY BOVINE TRYPSIN AND BOVINE PANCREATIC TRYPSIN-INHIBITOR .2. CRYSTALLOGRAPHIC REFINEMENT AT 1.9 A RESOLUTION, JOURNAL OF MOLECULAR BIOLOGY 89: 73 (1974). (10.1016/0022-2836(74)90163-6) / JOURNAL OF MOLECULAR BIOLOGY (1974)
JONES A FRODO ELECTRON DENSI (1980).
KARPLUS, M, PROTEIN STRUCTURAL FLUCTUATIONS DURING A PERIOD OF 100-PS, NATURE 277: 578 (1979). (10.1038/277578a0) / NATURE (1979)
LANGRIDGE, R, COMPUTERS LIFE SCI R: 53 (1975). / COMPUTERS LIFE SCI R (1975)
LANGRIDGE, R, INTERACTIVE 3-DIMENSIONAL COMPUTER GRAPHICS IN MOLECULAR-BIOLOGY, FEDERATION PROCEEDINGS 33: 2332 (1974). / FEDERATION PROCEEDINGS (1974)
LANGRIDGE, R, MOLECULAR CONFIGURATION OF DEOXYRIBONUCLEIC ACID .2. MOLECULAR MODELS AND THEIR FOURIER TRANSFORMS, JOURNAL OF MOLECULAR BIOLOGY 2: 38 (1960). (10.1016/S0022-2836(60)80005-8) / JOURNAL OF MOLECULAR BIOLOGY (1960)
LANGRIDGE, R, P IBM SCI COMPUTING: 305 (1965). / P IBM SCI COMPUTING (1965)
LEE, B, INTERPRETATION OF PROTEIN STRUCTURES - ESTIMATION OF STATIC ACCESSIBILITY, JOURNAL OF MOLECULAR BIOLOGY 55: 379 (1971). (10.1016/0022-2836(71)90324-X) / JOURNAL OF MOLECULAR BIOLOGY (1971)
LEVINTHAL, C, P IBM SCI COMPUTING: 315 (1965). / P IBM SCI COMPUTING (1965)
LEVINTHAL, C, MOLECULAR MODEL-BUILDING BY COMPUTER, SCIENTIFIC AMERICAN 214: 42 (1966). / SCIENTIFIC AMERICAN (1966)
LIPSCOMB, W.N., STRUCTURE OF CARBOXYPEPTIDASE A .8. ATOMIC INTERPRETATION AT 0.2 NM RESOLUTION, A NEW STUDY OF COMPLEX OF GLYCYL-L-TYROSINE WITH CPA, AND MECHANISTIC DEDUCTIONS, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 257: 177 (1970). / PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES (1970)
Max, N. L., Computers & Chemistry 5: 19 (1981). (10.1016/0097-8485(81)80003-4) / Computers & Chemistry (1981)
MAX, N.L., COMPUT GRAPH 13: 165 (1979). (10.1145/965103.807439) / COMPUT GRAPH (1979)
NEWMAN W.M. PRINCIPLES INTERACTI (1979).
PORTER, T.K., COMP GRAPHICS 12: 282 (1978). (10.1145/965139.639789) / COMP GRAPHICS (1978)
RICHARDS, F.M., AREAS, VOLUMES, PACKING, AND PROTEIN-STRUCTURE, ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING 6: 151 (1977). (10.1146/annurev.bb.06.060177.001055) / ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING (1977)
RICHARDS, F.M., MATCHING OF PHYSICAL MODELS TO 3-DIMENSIONAL ELECTRON-DENSITY MAPS - A SIMPLE OPTICAL DEVICE, JOURNAL OF MOLECULAR BIOLOGY 37: 225 (1968). (10.1016/0022-2836(68)90085-5) / JOURNAL OF MOLECULAR BIOLOGY (1968)
RITCHIE, D.M., COMMUN ACM 17: 7 (1974). / COMMUN ACM (1974)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 1:45 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 12:32 a.m.)
Indexed	3 weeks, 1 day ago (Aug. 2, 2025, 12:11 a.m.)
Issued	44 years, 6 months ago (Feb. 13, 1981)
Published	44 years, 6 months ago (Feb. 13, 1981)
Published Print	44 years, 6 months ago (Feb. 13, 1981)

Funders 0

None

BibTeX

@article{Langridge_1981, title={Real-Time Color Graphics in Studies of Molecular Interactions}, volume={211}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7455704}, DOI={10.1126/science.7455704}, number={4483}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Langridge, Robert and Ferrin, Thomas E. and Kuntz, Irwin D. and Connolly, Michael L.}, year={1981}, month=feb, pages={661–666} }

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