DOI: 10.1126/science.7112128. Glycolipids in Mammalian Epidermis: Structure and Function in the Water Barrier

Glycolipids in Mammalian Epidermis: Structure and Function in the Water Barrier

10.1126/science.7112128

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

In the epidermis of terrestrial vertebrates, lipid lamellae between the horny cells are thought to form a barrier to water loss. The lipids are extruded from living cells after assembly in lamellar granules. This assembly might be promoted by recently identified 1-(3′- O -acyl)-β-D-glucosyl- N -(ω-hydroxyacyl)sphingosines, which have 30- and 32-carbon hydroxy acids as amides and linoleic acid esterified to glucose. Such a role for these molecules could explain the effects of essential fatty acid deficiency, in which the lamellar granules fail to assemble and the barrier to water diffusion is lost.

Bibliography

Wertz, P. W., & Downing, D. T. (1982). Glycolipids in Mammalian Epidermis: Structure and Function in the Water Barrier. Science, 217(4566), 1261â1262.

Authors 2

Philip W. Wertz (first)
Donald T. Downing (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:56 p.m.)
Indexed	3 weeks, 4 days ago (Aug. 2, 2025, 12:54 a.m.)
Issued	42 years, 11 months ago (Sept. 24, 1982)
Published	42 years, 11 months ago (Sept. 24, 1982)
Published Print	42 years, 11 months ago (Sept. 24, 1982)

Funders 0

None

BibTeX

@article{Wertz_1982, title={Glycolipids in Mammalian Epidermis: Structure and Function in the Water Barrier}, volume={217}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7112128}, DOI={10.1126/science.7112128}, number={4566}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Wertz, Philip W. and Downing, Donald T.}, year={1982}, month=sep, pages={1261–1262} }

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