DOI: 10.1126/science.7053574. Human Cell Hybrids: Analysis of Transformation and Tumorigenicity

Human Cell Hybrids: Analysis of Transformation and Tumorigenicity

10.1126/science.7053574

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Intraspecific human-human cell hybrids provide a stable model system with which to investigate the genetic control of transformed and tumorigenic phenotypes. Using this system it has been shown that these phenotypes are under separate genetic control. Furthermore, the tumorigenic phenotype can be complemented by fusion of different tumorigenic cells, resulting in nontumorigenic hybrids. This system also provides information on the control of differentiated function. Molecular cytogenetic techniques should reveal the nature of the chromosomal control of neoplastic transformation.

Bibliography

Stanbridge, E. J., Der, C. J., Doersen, C.-J., Nishimi, R. Y., Peehl, D. M., Weissman, B. E., & Wilkinson, J. E. (1982). Human Cell Hybrids: Analysis of Transformation and Tumorigenicity. Science, 215(4530), 252â259.

Authors 7

Eric J. Stanbridge (first)
Channing J. Der (additional)
Claus-Jens Doersen (additional)
Robyn Y. Nishimi (additional)
Donna M. Peehl (additional)
Bernard E. Weissman (additional)
Joyce E. Wilkinson (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:10 p.m.)
Indexed	11 months, 2 weeks ago (Sept. 7, 2024, 8:48 a.m.)
Issued	43 years, 7 months ago (Jan. 15, 1982)
Published	43 years, 7 months ago (Jan. 15, 1982)
Published Print	43 years, 7 months ago (Jan. 15, 1982)

Funders 0

None

BibTeX

@article{Stanbridge_1982, title={Human Cell Hybrids: Analysis of Transformation and Tumorigenicity}, volume={215}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7053574}, DOI={10.1126/science.7053574}, number={4530}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Stanbridge, Eric J. and Der, Channing J. and Doersen, Claus-Jens and Nishimi, Robyn Y. and Peehl, Donna M. and Weissman, Bernard E. and Wilkinson, Joyce E.}, year={1982}, month=jan, pages={252–259} }

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