DOI: 10.1126/science.7015506. Contractility of Bile Canaliculi: Implications for Liver Function

Contractility of Bile Canaliculi: Implications for Liver Function

10.1126/science.7015506

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Dynamic contractions of bile canaliculi were observed in groups of cultured hepatocytes by time-lapse cinephotomicrography during the early stages of monolayer formation. The contractions, which were forceful and appeared to have a pumping action, may facilitate the flow of bile in the liver's canalicular system.

Bibliography

Oshio, C., & Phillips, M. J. (1981). Contractility of Bile Canaliculi: Implications for Liver Function. Science, 212(4498), 1041â1042.

Authors 2

C. Oshio (first)
M. J. Phillips (additional)

References 32 Referenced 143

ADLER, M, J PATHOL 98: 603 (1980). / J PATHOL (1980)
BOYER, J.L., NEW CONCEPTS OF MECHANISMS OF HEPATOCYTE BILE FORMATION, PHYSIOLOGICAL REVIEWS 60: 303 (1980). (10.1152/physrev.1980.60.2.303) / PHYSIOLOGICAL REVIEWS (1980)
BRADLEY, S.E., AM J PHYSIOL 235: 570 (1978). / AM J PHYSIOL (1978)
CLARKE, M, NON-MUSCLE CONTRACTILE PROTEINS - ROLE OF ACTIN AND MYOSIN IN CELL MOTILITY AND SHAPE DETERMINATION, ANNUAL REVIEW OF BIOCHEMISTRY 46: 797 (1977). (10.1146/annurev.bi.46.070177.004053) / ANNUAL REVIEW OF BIOCHEMISTRY (1977)
DUBIN, M, PHALLOIDIN-INDUCED CHOLESTASIS IN RAT - RELATION TO CHANGES IN MICROFILAMENTS, GASTROENTEROLOGY 75: 450 (1978). (10.1016/0016-5085(78)90849-1) / GASTROENTEROLOGY (1978)
Elias, E., Proceedings of the National Academy of Sciences of the United States of America 77: 2229 (1980). / Proceedings of the National Academy of Sciences of the United States of America (1980)
FORKER, E.L., MECHANISMS OF HEPATIC BILE FORMATION, ANNUAL REVIEW OF PHYSIOLOGY 39: 323 (1977). (10.1146/annurev.ph.39.030177.001543) / ANNUAL REVIEW OF PHYSIOLOGY (1977)
FRANKE, W.W., CHARACTERIZATION OF THE INTERMEDIATE-SIZED FILAMENTS IN LIVER-CELLS BY IMMUNOFLUORESCENCE AND ELECTRON-MICROSCOPY, BIOLOGIE CELLULAIRE 34: 99 (1979). / BIOLOGIE CELLULAIRE (1979)
FRENCH, S.W., ULTRASTRUCTURAL LOCALIZATION OF ACTIN-LIKE FILAMENTS IN RAT HEPATOCYTES, GASTROENTEROLOGY 68: 765 (1975). (10.1016/S0016-5085(75)80288-5) / GASTROENTEROLOGY (1975)
GABBIANI, G, LABORATORY INVESTIGATION 33: 362 (1975). / LABORATORY INVESTIGATION (1975)
GARDNER, B, STUDIES OF BILE-ACID SECRETION BY ISOLATED RAT HEPATOCYTES, JOURNAL OF LIPID RESEARCH 19: 985 (1978). (10.1016/S0022-2275(20)40682-0) / JOURNAL OF LIPID RESEARCH (1978)
GRAF, J, HEPATOBILIARY SYSTEM: 43 (1975). / HEPATOBILIARY SYSTEM (1975)
HITCHCOCK, S.E., REGULATION OF MOTILITY IN NON-MUSCLE CELLS, JOURNAL OF CELL BIOLOGY 74: 1 (1977). (10.1083/jcb.74.1.1) / JOURNAL OF CELL BIOLOGY (1977)
HOLBOROW, E.J., DEMONSTRATION OF SMOOTH-MUSCLE CONTRACTILE PROTEIN ANTIGENS IN LIVER AND EPITHELIAL-CELLS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 254: 489 (1975). (10.1111/j.1749-6632.1975.tb29196.x) / ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (1975)
JAVITT, N.B., CHEM PHYSL BILE PIGM: 377 (1977). / CHEM PHYSL BILE PIGM (1977)
KORN, E.D., BIOCHEMISTRY OF ACTOMYOSIN-DEPENDENT CELL MOTILITY - REVIEW, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75: 588 (1978). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1978)
LAISHES, B.A., CONDITIONS AFFECTING PRIMARY-CELL CULTURES OF FUNCTIONAL ADULT RAT HEPATOCYTES .1. EFFECT OF INSULIN, IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION 12: 521 (1976). / IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION (1976)
LAYDEN, T.J., BILE FORMATION IN RAT - ROLE OF PARACELLULAR SHUNT PATHWAY, JOURNAL OF CLINICAL INVESTIGATION 62: 1375 (1978). (10.1172/JCI109258) / JOURNAL OF CLINICAL INVESTIGATION (1978)
MCDOWELL, E.M., HISTOLOGIC FIXATIVES SUITABLE FOR DIAGNOSTIC LIGHT AND ELECTRON-MICROSCOPY, ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 100: 405 (1976). / ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (1976)
ODA, M, ULTRASTRUCTURE OF BILE CANALICULI, WITH SPECIAL REFERENCE TO SURFACE COAT AND PERICANALICULAR WEB, LABORATORY INVESTIGATION 31: 314 (1974). / LABORATORY INVESTIGATION (1974)
PHILLIPS, M.J., MICROFILAMENT DYSFUNCTION AS A POSSIBLE CAUSE OF INTRAHEPATIC CHOLESTASIS, GASTROENTEROLOGY 69: 48 (1975). (10.1016/S0016-5085(19)32635-6) / GASTROENTEROLOGY (1975)
PHILLIPS, M.J., J ULTRASTRUCT RES 57: 162 (1976). / J ULTRASTRUCT RES (1976)
PHILLIPS, M.J., MEMBRANE ALTERATIONS: 343 (1977). / MEMBRANE ALTERATIONS (1977)
PRENTKI, M, ACTIN MICROFILAMENTS, CELL-SHAPE, AND SECRETORY PROCESSES IN ISOLATED RAT HEPATOCYTES - EFFECT OF PHALLOIDIN AND CYTOCHALASIN-D, JOURNAL OF CELL BIOLOGY 81: 592 (1979). (10.1083/jcb.81.3.592) / JOURNAL OF CELL BIOLOGY (1979)
SATO, T, J ELECTRON MICROSC 17: 158 (1968). / J ELECTRON MICROSC (1968)
SEGLEN, P.O., METHOD CELL BIOL 8: 39 (1976). / METHOD CELL BIOL (1976)
Sperber, I., The Biliary System: 457 (1965). / The Biliary System (1965)
Sperber, I., Proceedings of the First Pharmacological Meeting 4: 137 (1963). / Proceedings of the First Pharmacological Meeting (1963)
WEIHING, R.R., METHODS AND ACHIEVEMENTS IN EXPERIMENTAL PATHOLOGY 8: 42 (1979). / METHODS AND ACHIEVEMENTS IN EXPERIMENTAL PATHOLOGY (1979)
Wieland, T., Pathogenesis and Mechanisms of Liver Cell Necrosis: 193 (1975). / Pathogenesis and Mechanisms of Liver Cell Necrosis (1975)
YOUSEF, I.M., STUDIES ON PREPARATION OF RAT-LIVER PLASMA-MEMBRANE FRACTIONS AND ON THEIR POLYPEPTIDE PATTERNS, CANADIAN JOURNAL OF BIOCHEMISTRY 56: 713 (1978). (10.1139/o78-107) / CANADIAN JOURNAL OF BIOCHEMISTRY (1978)
YOUSEF, I.M., BILE-ACID SYNTHESIS IN ISOLATED RAT HEPATOCYTES, CANADIAN JOURNAL OF BIOCHEMISTRY 56: 780 (1978). (10.1139/o78-118) / CANADIAN JOURNAL OF BIOCHEMISTRY (1978)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 1:45 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:59 p.m.)
Indexed	1 month, 1 week ago (July 25, 2025, 5:57 a.m.)
Issued	44 years, 3 months ago (May 29, 1981)
Published	44 years, 3 months ago (May 29, 1981)
Published Print	44 years, 3 months ago (May 29, 1981)

Funders 0

None

BibTeX

@article{Oshio_1981, title={Contractility of Bile Canaliculi: Implications for Liver Function}, volume={212}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7015506}, DOI={10.1126/science.7015506}, number={4498}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Oshio, C. and Phillips, M. J.}, year={1981}, month=may, pages={1041–1042} }

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    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1981,
        5,
        29
      ]
    ]
  }
}