DOI: 10.1126/science.7015504. Micromolar Calcium Stimulates Proteolysis and Glutamate Binding in Rat Brain Synaptic Membranes

Micromolar Calcium Stimulates Proteolysis and Glutamate Binding in Rat Brain Synaptic Membranes

10.1126/science.7015504

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Incubation of cortical synaptic membranes with low concentrations of calcium resulted in a decrease in the amount of a high-molecular-weight doublet protein and an increase in the sodium-independent binding of glutamate. Both effects were blocked by the thiol protease inhibitor leupeptin. These results suggest that calcium-induced proteolysis of membrane components regulates the number of glutamate receptors in neuronal membranes.

Bibliography

Baudry, M., Bundman, M. C., Smith, E. K., & Lynch, G. S. (1981). Micromolar Calcium Stimulates Proteolysis and Glutamate Binding in Rat Brain Synaptic Membranes. Science, 212(4497), 937â938.

Authors 4

Michel Baudry (first)
Marsha C. Bundman (additional)
Elizabeth K. Smith (additional)
Gary S. Lynch (additional)

References 26 Referenced 151

ANDERTON, B.H., NEUROFILAMENTS, BIOCHEMICAL SOCIETY TRANSACTIONS 4: 544 (1976). (10.1042/bst0040544) / BIOCHEMICAL SOCIETY TRANSACTIONS (1976)
BAUDRY, M, HYPOTHESIS REGARDING THE CELLULAR MECHANISMS RESPONSIBLE FOR LONG-TERM SYNAPTIC POTENTIATION IN THE HIPPOCAMPUS, EXPERIMENTAL NEUROLOGY 68: 202 (1980). (10.1016/0014-4886(80)90078-3) / EXPERIMENTAL NEUROLOGY (1980)
BAUDRY, M, INCREASE IN GLUTAMATE RECEPTORS FOLLOWING REPETITIVE ELECTRICAL-STIMULATION IN HIPPOCAMPAL SLICES, LIFE SCIENCES 27: 325 (1980). (10.1016/0024-3205(80)90200-3) / LIFE SCIENCES (1980)
BAUDRY, M, REGULATION OF GLUTAMATE RECEPTORS BY CATIONS, NATURE 282: 748 (1979). (10.1038/282748a0) / NATURE (1979)
BAUDRY, M, REGULATION OF HIPPOCAMPAL GLUTAMATE RECEPTORS - EVIDENCE FOR THE INVOLVEMENT OF A CALCIUM-ACTIVATED PROTEASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 77: 2298 (1980). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1980)
CATT, K.J., HORMONAL-REGULATION OF PEPTIDE RECEPTORS AND TARGET-CELL RESPONSES, NATURE 280: 109 (1979). (10.1038/280109a0) / NATURE (1979)
COHEN, R.S., STRUCTURE OF POSTSYNAPTIC DENSITIES ISOLATED FROM DOG CEREBRAL-CORTEX .1. OVERALL MORPHOLOGY AND PROTEIN-COMPOSITION, JOURNAL OF CELL BIOLOGY 74: 181 (1977). (10.1083/jcb.74.1.181) / JOURNAL OF CELL BIOLOGY (1977)
DAVIES, PJA, FILAMET-ACTIN INTERACTION - DISSOCIATION OF BINDING FROM GELATION BY CA2+-ACTIVATED PROTEOLYSIS, JOURNAL OF BIOLOGICAL CHEMISTRY 253: 4036 (1978). (10.1016/S0021-9258(17)34795-6) / JOURNAL OF BIOLOGICAL CHEMISTRY (1978)
DAYTON, W.R., CA-2+-ACTIVATED PROTEASE POSSIBLY INVOLVED IN MYOFIBRILLAR PROTEIN TURNOVER - PURIFICATION FROM PORCINE MUSCLE, BIOCHEMISTRY 15: 2150 (1976). (10.1021/bi00655a019) / BIOCHEMISTRY (1976)
10.1126/science.769162
GILBERT, D.S., NEUROFILAMENT DISGUISE, DESTRUCTION AND DISCIPLINE, NATURE 256: 586 (1975). (10.1038/256586a0) / NATURE (1975)
HEIDMANN, T, STRUCTURAL AND FUNCTIONAL PROPERTIES OF ACETYLCHOLINE-RECEPTOR PROTEIN IN ITS PURIFIED AND MEMBRANE-BOUND STATES, ANNUAL REVIEW OF BIOCHEMISTRY 47: 317 (1978). (10.1146/annurev.bi.47.070178.001533) / ANNUAL REVIEW OF BIOCHEMISTRY (1978)
10.1126/science.6157192
HOTSON, J.R., ANOMALOUS INWARD RECTIFICATION IN HIPPOCAMPAL-NEURONS, JOURNAL OF NEUROPHYSIOLOGY 42: 889 (1979). (10.1152/jn.1979.42.3.889) / JOURNAL OF NEUROPHYSIOLOGY (1979)
10.1038/227680a0
LASEK, R.J., CELL MOTILITY: 1021 (1976). / CELL MOTILITY (1976)
LEE, K.S., BRIEF BURSTS OF HIGH-FREQUENCY STIMULATION PRODUCE 2 TYPES OF STRUCTURAL-CHANGE IN RAT HIPPOCAMPUS, JOURNAL OF NEUROPHYSIOLOGY 44: 247 (1980). (10.1152/jn.1980.44.2.247) / JOURNAL OF NEUROPHYSIOLOGY (1980)
LEFKOWITZ, R.J., BETA-ADRENERGIC-RECEPTOR AND ADENYLATE-CYCLASE, BIOCHIMICA ET BIOPHYSICA ACTA 457: 1 (1976). (10.1016/0304-4157(76)90012-5) / BIOCHIMICA ET BIOPHYSICA ACTA (1976)
NICOLSON, G.L., CURR TOP DEV BIOL 13: 305 (1979). (10.1016/S0070-2153(08)60700-0) / CURR TOP DEV BIOL (1979)
PANT, H.C., CALCIUM ACTIVATED PROTEASE IN SQUID AXOPLASM, JOURNAL OF NEUROCHEMISTRY 32: 99 (1979). (10.1111/j.1471-4159.1979.tb04515.x) / JOURNAL OF NEUROCHEMISTRY (1979)
PHILLIPS, D.R., CA2+-DEPENDENT PROTEASE IN HUMAN PLATELETS - SPECIFIC CLEAVAGE OF PLATELET POLYPEPTIDES IN PRESENCE OF ADDED CA2+, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 5602 (1977). (10.1016/S0021-9258(17)40062-7) / JOURNAL OF BIOLOGICAL CHEMISTRY (1977)
SCHLAEPFER, W.W., CHARACTERIZATION OF THE CALCIUM-INDUCED DISRUPTION OF NEUROFILAMENTS IN RAT PERIPHERAL-NERVE, BRAIN RESEARCH 168: 299 (1979). (10.1016/0006-8993(79)90171-9) / BRAIN RESEARCH (1979)
SCHLAEPFER, W.W., CHEMICAL AND STRUCTURAL-CHANGES OF NEUROFILAMENTS IN TRANSECTED RAT SCIATIC-NERVE, JOURNAL OF CELL BIOLOGY 78: 369 (1978). (10.1083/jcb.78.2.369) / JOURNAL OF CELL BIOLOGY (1978)
TOYOOKA, T, INHIBITION OF PROTEOLYTIC ACTIVITY OF CALCIUM ACTIVATED NEUTRAL PROTEASE BY LEUPEPTIN AND ANTIPAIN, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 82: 484 (1978). (10.1016/0006-291X(78)90900-2) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1978)
VARGAS, F, PARTICIPATION OF CYSTEIN PROTEINASE IN THE HIGH-AFFINITY CA2+-DEPENDENT BINDING OF GLUTAMATE TO HIPPOCAMPAL SYNAPTIC-MEMBRANES, NEUROPHARMACOLOGY 19: 791 (1980). (10.1016/0028-3908(80)90072-6) / NEUROPHARMACOLOGY (1980)
WONG, RKS, INTRA-DENDRITIC RECORDINGS FROM HIPPOCAMPAL NEURONS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 986 (1979). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1979)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 1:45 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 6 p.m.)
Indexed	1 day, 18 hours ago (Sept. 4, 2025, 9:49 a.m.)
Issued	44 years, 3 months ago (May 22, 1981)
Published	44 years, 3 months ago (May 22, 1981)
Published Print	44 years, 3 months ago (May 22, 1981)

Funders 0

None

BibTeX

@article{Baudry_1981, title={Micromolar Calcium Stimulates Proteolysis and Glutamate Binding in Rat Brain Synaptic Membranes}, volume={212}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.7015504}, DOI={10.1126/science.7015504}, number={4497}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Baudry, Michel and Bundman, Marsha C. and Smith, Elizabeth K. and Lynch, Gary S.}, year={1981}, month=may, pages={937–938} }

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