DOI: 10.1126/science.6836300. Synaptic Activity Mediates Death of Hypoxic Neurons

Synaptic Activity Mediates Death of Hypoxic Neurons

10.1126/science.6836300

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Cultured hippocampal neurons, when exposed to cyanide or an anoxic atmosphere in the early stages of differentiation, were not visibly affected. However, neurons in mature cultures died when exposed to cyanide or anoxia. Cell death could be prevented by treatment with magnesium, which eliminates synaptic activity. These observations suggest that damage in hypoxic neurons is mediated by synaptic activity.

Bibliography

Rothman, S. M. (1983). Synaptic Activity Mediates Death of Hypoxic Neurons. Science, 220(4596), 536â537.

Authors 1

Steven M. Rothman (first)

References 22 Referenced 349

BOTTENSTEIN, J, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 518 (1979). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1979)
10.1126/science.7123229
DUFFY, T.E., CARBOHYDRATE AND ENERGY METABOLISM IN PERINATAL RAT-BRAIN - RELATION TO SURVIVAL IN ANOXIA, JOURNAL OF NEUROCHEMISTRY 24: 271 (1975). (10.1111/j.1471-4159.1975.tb11875.x) / JOURNAL OF NEUROCHEMISTRY (1975)
FAZEKAS, J.F., Tolerance of the newborn to anoxia, AMERICAN JOURNAL OF PHYSIOLOGY 134: 281 (1941). (10.1152/ajplegacy.1941.134.2.281) / AMERICAN JOURNAL OF PHYSIOLOGY (1941)
JACKSON, M.B., J NEUROSCI 23: 1052 (1982). / J NEUROSCI (1982)
KIM, S.U., BRAIN HYPOXIA STUDIED IN MOUSE CENTRAL NERVOUS-SYSTEM CULTURES .1. SEQUENTIAL CELLULAR CHANGES, LABORATORY INVESTIGATION 33: 658 (1975). / LABORATORY INVESTIGATION (1975)
10.1126/science.205953
MELDRUM, B.S., PROLONGED EPILEPTIC SEIZURES IN PRIMATES - ISCHEMIC CELL CHANGE AND ITS RELATION TO ICTAL PHYSIOLOGICAL EVENTS, ARCHIVES OF NEUROLOGY 28: 10 (1973). (10.1001/archneur.1973.00490190028002) / ARCHIVES OF NEUROLOGY (1973)
MELDRUM, B.S., SYSTEMIC FACTORS AND EPILEPTIC BRAIN-DAMAGE - PROLONGED SEIZURES IN PARALYZED, ARTIFICIALLY VENTILATED BABOONS, ARCHIVES OF NEUROLOGY 29: 82 (1973). (10.1001/archneur.1973.00490260026003) / ARCHIVES OF NEUROLOGY (1973)
MICHENFELDER, J.D., CEREBRAL PROTECTION BY BARBITURATE ANESTHESIA - USE AFTER MIDDLE CEREBRAL-ARTERY OCCLUSION IN JAVA MONKEYS, ARCHIVES OF NEUROLOGY 33: 345 (1976). (10.1001/archneur.1976.00500050031006) / ARCHIVES OF NEUROLOGY (1976)
10.1126/science.6262912
PEACOCK, J.H., MORPHOLOGY OF DISSOCIATED HIPPOCAMPAL CULTURES FROM FETAL MICE, BRAIN RESEARCH 169: 231 (1979). (10.1016/0006-8993(79)91027-8) / BRAIN RESEARCH (1979)
PEACOCK, J.H., ELECTROPHYSIOLOGY OF DISSOCIATED HIPPOCAMPAL CULTURES FROM FETAL MICE, BRAIN RESEARCH 169: 247 (1979). (10.1016/0006-8993(79)91028-X) / BRAIN RESEARCH (1979)
ROTHMAN, S, A SCANNING ELECTRON-MICROSCOPE STUDY OF THE INVITRO DEVELOPMENT OF DISSOCIATED HIPPOCAMPAL CELLS, JOURNAL OF COMPARATIVE NEUROLOGY 195: 141 (1981). (10.1002/cne.901950108) / JOURNAL OF COMPARATIVE NEUROLOGY (1981)
ROTHMAN, S.M., SOCIETY FOR NEUROSCIENCE. ABSTRACTS 8: 800 (1982). / SOCIETY FOR NEUROSCIENCE. ABSTRACTS (1982)
10.1126/science.386513
SCHULZ, D.W., BARBITURATE ENHANCEMENT OF GABA-MEDIATED INHIBITION AND ACTIVATION OF CHLORIDE-ION CONDUCTANCE - CORRELATION WITH ANTICONVULSANT AND ANESTHETIC ACTIONS, BRAIN RESEARCH 209: 177 (1981). (10.1016/0006-8993(81)91179-3) / BRAIN RESEARCH (1981)
SEGAL, M, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 8: 800 (1982). / SOCIETY FOR NEUROSCIENCE. ABSTRACTS (1982)
SIESJO, B.K., CELL-DAMAGE IN THE BRAIN - A SPECULATIVE SYNTHESIS, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 1: 155 (1981). (10.1038/jcbfm.1981.18) / JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (1981)
SMITH, A.L., BARBITURATE PROTECTION IN ACUTE FOCAL CEREBRAL ISCHEMIA, STROKE 5: 1 (1974). (10.1161/01.STR.5.1.1) / STROKE (1974)
THURSTON, J.H., EFFECT OF ISCHEMIA ON METABOLISM OF BRAIN OF NEWBORN MOUSE, AMERICAN JOURNAL OF PHYSIOLOGY 216: 348 (1969). (10.1152/ajplegacy.1969.216.2.348) / AMERICAN JOURNAL OF PHYSIOLOGY (1969)
YAVIN, E, ATTACHMENT AND CULTURE OF DISSOCIATED CELLS FROM RAT EMBRYO CEREBRAL HEMISPHERES ON POLYLYSINE-COATED SURFACE, JOURNAL OF CELL BIOLOGY 62: 540 (1974). (10.1083/jcb.62.2.540) / JOURNAL OF CELL BIOLOGY (1974)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 2:37 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:23 p.m.)
Indexed	2 months, 3 weeks ago (June 12, 2025, 5:44 a.m.)
Issued	42 years, 4 months ago (April 29, 1983)
Published	42 years, 4 months ago (April 29, 1983)
Published Print	42 years, 4 months ago (April 29, 1983)

Funders 0

None

BibTeX

@article{Rothman_1983, title={Synaptic Activity Mediates Death of Hypoxic Neurons}, volume={220}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6836300}, DOI={10.1126/science.6836300}, number={4596}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Rothman, Steven M.}, year={1983}, month=apr, pages={536–537} }

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