Novel Proteinaceous Infectious Particles Cause Scrapie
10.1126/science.6801762
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

After infection and a prolonged incubation period, the scrapie agent causes a degenerative disease of the central nervous system in sheep and goats. Six lines of evidence including sensitivity to proteases demonstrate that this agent contains a protein that is required for infectivity. Although the scrapie agent is irreversibly inactivated by alkali, five procedures with more specificity for modifying nucleic acids failed to cause inactivation. The agent shows heterogeneity with respect to size, apparently a result of its hydrophobicity; the smallest form may have a molecular weight of 50,000 or less. Because the novel properties of the scrapie agent distinguish it from viruses, plasmids, and viroids, a new term "prion" is proposed to denote a small pro teinaceous in fectious particle which is resistant to inactivation by most procedures that modify nucleic acids. Knowledge of the scrapie agent structure may have significance for understanding the causes of several degenerative diseases.

Bibliography

Prusiner, S. B. (1982). Novel Proteinaceous Infectious Particles Cause Scrapie. Science, 216(4542), 136–144.

Authors 1
  1. Stanley B. Prusiner (first)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 2:30 p.m.)
Deposited 1 year, 7 months ago (Jan. 14, 2024, 6:40 p.m.)
Indexed 14 minutes ago (Aug. 30, 2025, 5:19 p.m.)
Issued 43 years, 4 months ago (April 9, 1982)
Published 43 years, 4 months ago (April 9, 1982)
Published Print 43 years, 4 months ago (April 9, 1982)
Funders 0

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@article{Prusiner_1982, title={Novel Proteinaceous Infectious Particles Cause Scrapie}, volume={216}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6801762}, DOI={10.1126/science.6801762}, number={4542}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Prusiner, Stanley B.}, year={1982}, month=apr, pages={136–144} }