DOI: 10.1126/science.6612345. Acetylcholine Mediates a Slow Synaptic Potential in Hippocampal Pyramidal Cells

Acetylcholine Mediates a Slow Synaptic Potential in Hippocampal Pyramidal Cells

10.1126/science.6612345

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The hippocampal slice preparation was used to study the role of acetylcholine as a synaptic transmitter. Bath-applied acetylcholine had three actions on pyramidal cells: (i) depolarization associated with increased input resistance, (ii) blockade of calcium-activated potassium responses, and (iii) blockade of accommodation of cell discharge. All these actions were reversed by the muscarinic antagonist atropine. Stimulation of sites in the slice known to contain cholinergic fibers mimicked all the actions. Furthermore, these evoked synaptic responses were enhanced by the cholinesterase inhibitor eserine and were blocked by atropine. These findings provide electrophysiological support for the role of acetylcholine as a synaptic transmitter in the brain and demonstrate that nonclassical synaptic responses involving the blockade of membrane conductances exist in the brain.

Bibliography

Cole, A. E., & Nicoll, R. A. (1983). Acetylcholine Mediates a Slow Synaptic Potential in Hippocampal Pyramidal Cells. Science, 221(4617), 1299â1301.

Authors 2

A. E. Cole (first)
R. A. Nicoll (additional)

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Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 2:37 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:08 p.m.)
Indexed	1 day, 9 hours ago (Sept. 4, 2025, 9:54 a.m.)
Issued	41 years, 11 months ago (Sept. 23, 1983)
Published	41 years, 11 months ago (Sept. 23, 1983)
Published Print	41 years, 11 months ago (Sept. 23, 1983)

Funders 0

None

BibTeX

@article{Cole_1983, title={Acetylcholine Mediates a Slow Synaptic Potential in Hippocampal Pyramidal Cells}, volume={221}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6612345}, DOI={10.1126/science.6612345}, number={4617}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Cole, A. E. and Nicoll, R. A.}, year={1983}, month=sep, pages={1299–1301} }

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