DOI: 10.1126/science.653353. The Hydrophobic Effect and the Organization of Living Matter

The Hydrophobic Effect and the Organization of Living Matter

10.1126/science.653353

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Biological organization may be viewed as consisting of two stages: biosynthesis and assembly. The assembly process is largely under thermodynamic control; that is, as a first approximation it represents a search by each structural molecule for its state of lowest chemical potential. The hydrophobic effect is a unique organizing force, based on repulsion by the solvent instead of attractive forces at the site of organization. It is responsible for assembly of membranes of cells and intracellular compartments, and the absence of strong attractive forces makes the membranes fluid and deformable. The spontaneous folding of proteins, however, involves directed polar bonds, leading to more rigid structures. Intercellular organization probably involves polar bonds between cell surface proteins.

Bibliography

Tanford, C. (1978). The Hydrophobic Effect and the Organization of Living Matter. Science, 200(4345), 1012â1018.

Authors 1

Charles Tanford (first)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 12:35 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 6:24 p.m.)
Indexed	21 minutes ago (Aug. 30, 2025, 6:22 p.m.)
Issued	47 years, 2 months ago (June 2, 1978)
Published	47 years, 2 months ago (June 2, 1978)
Published Print	47 years, 2 months ago (June 2, 1978)

Funders 0

None

BibTeX

@article{Tanford_1978, title={The Hydrophobic Effect and the Organization of Living Matter}, volume={200}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.653353}, DOI={10.1126/science.653353}, number={4345}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Tanford, Charles}, year={1978}, month=jun, pages={1012–1018} }

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