Mitogenic Growth Factors and Nerve Dependence of Limb Regeneration
10.1126/science.6474177
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Regeneration of the amphibian limb after amputation depends on division of blastemal cells, the progenitor cells of the regenerate. This division is controlled, at least in the early stages of regeneration, by the nerve supply to the blastema. A monoclonal antibody to newt blastema cells has provided evidence that Schwann cells and muscle fibers contribute to the blastema, and identifies blastemal cells whose division is persistently dependent on the nerve. Glial growth factor, a molecule identified by its action on rat Schwann cells, is present in the newt blastema and is lost on denervation.

Bibliography

Brockes, J. P. (1984). Mitogenic Growth Factors and Nerve Dependence of Limb Regeneration. Science, 225(4668), 1280–1287.

Authors 1
  1. Jeremy P. Brockes (first)
References 90 Referenced 126
  1. AGUAYO, A.J., NEONATAL NEURONAL LOSS IN RAT SUPERIOR CERVICAL GANGLIA - RETROGRADE EFFECTS ON DEVELOPING PREGANGLIONIC AXONS AND SCHWANN-CELLS, JOURNAL OF NEUROCYTOLOGY 5: 137 (1976). (10.1007/BF01181653) / JOURNAL OF NEUROCYTOLOGY (1976)
  2. BARNTAULT, D, J NEUROSCI RES 8: 477 (1982). (10.1002/jnr.490080235) / J NEUROSCI RES (1982)
  3. BISCHOFF R MUSCLE REGENERATION (1979).
  4. BOTTENSTEIN, J, METHODS IN ENZYMOLOGY 58: 94 (1979). (10.1016/S0076-6879(79)58127-0) / METHODS IN ENZYMOLOGY (1979)
  5. BROCKES, J.P., STUDIES ON CULTURED RAT SCHWANN-CELLS .1. ESTABLISHMENT OF PURIFIED POPULATIONS FROM CULTURES OF PERIPHERAL-NERVE, BRAIN RESEARCH 165: 105 (1979). (10.1016/0006-8993(79)90048-9) / BRAIN RESEARCH (1979)
  6. BROCKES J.P. DEV NERVOUS SYSTEM (1981).
  7. BROCKES, J.P., PURIFICATION AND PRELIMINARY CHARACTERIZATION OF A GLIAL GROWTH-FACTOR FROM THE BOVINE PITUITARY, JOURNAL OF BIOLOGICAL CHEMISTRY 255: 8374 (1980). (10.1016/S0021-9258(18)43500-4) / JOURNAL OF BIOLOGICAL CHEMISTRY (1980)
  8. BROCKES, J.P., STUDIES ON CULTURED SCHWANN-CELLS - THE INDUCTION OF MYELIN SYNTHESIS, AND THE CONTROL OF THEIR PROLIFERATION BY A NEW GROWTH-FACTOR, JOURNAL OF EXPERIMENTAL BIOLOGY 95: 215 (1981). (10.1242/jeb.95.1.215) / JOURNAL OF EXPERIMENTAL BIOLOGY (1981)
  9. BROCKES, J.P., SURFACE ANTIGENIC MARKER FOR RAT SCHWANN-CELLS, NATURE 266: 364 (1977). (10.1038/266364a0) / NATURE (1977)
  10. BROCKES J.P. unpublished data.
  11. CARLONE, R.L., BOVINE PITUITARY FIBROBLAST GROWTH-FACTOR HAS NEUROTROPHIC ACTIVITY ON NEWT LIMB REGENERATES AND SKELETAL-MUSCLES INVITRO, EXPERIMENTAL CELL RESEARCH 132: 15 (1981). (10.1016/0014-4827(81)90077-X) / EXPERIMENTAL CELL RESEARCH (1981)
  12. CASSEL, D, MITOGENICITY OF BRAIN AXOLEMMA MEMBRANES AND SOLUBLE FACTORS FOR DORSAL-ROOT GANGLION SCHWANN-CELLS, JOURNAL OF CELLULAR BIOCHEMISTRY 18: 433 (1982). (10.1002/jcb.1982.240180405) / JOURNAL OF CELLULAR BIOCHEMISTRY (1982)
  13. CHALKLEY, D.T., A QUANTITATIVE HISTOLOGICAL ANALYSIS OF FORELIMB REGENERATION IN TRITURUS VIRIDESCENS, JOURNAL OF MORPHOLOGY 94: 21 (1954). (10.1002/jmor.1050940103) / JOURNAL OF MORPHOLOGY (1954)
  14. CHOO, A.F., NERVE TROPHIC EFFECTS - PARTIAL-PURIFICATION FROM CHICK-EMBRYO BRAINS OF PROTEINS THAT STIMULATE PROTEIN-SYNTHESIS IN CULTURED NEWT BLASTEMATA, EXPERIMENTAL NEUROLOGY 73: 558 (1981). (10.1016/0014-4886(81)90289-2) / EXPERIMENTAL NEUROLOGY (1981)
  15. CHOO, A.F., NERVE TROPHIC EFFECTS - INVITRO ASSAY FOR FACTORS INVOLVED IN REGULATION OF PROTEIN-SYNTHESIS IN REGENERATING AMPHIBIAN LIMBS, JOURNAL OF EXPERIMENTAL ZOOLOGY 206: 347 (1978). (10.1002/jez.1402060306) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1978)
  16. DEVRIES, G.H., AXOLEMMA-ENRICHED FRACTIONS-ISOLATED FROM PNS AND CNS ARE MITOGENIC FOR CULTURED SCHWANN-CELLS, DEVELOPMENTAL BRAIN RESEARCH 3: 295 (1982). (10.1016/0165-3806(82)90028-1) / DEVELOPMENTAL BRAIN RESEARCH (1982)
  17. 10.1126/science.948762
  18. GAMBARINI, A.G., PURIFICATION AND PARTIAL CHARACTERIZATION OF AN ACIDIC FIBROBLAST GROWTH-FACTOR FROM BOVINE PITUITARY, JOURNAL OF BIOLOGICAL CHEMISTRY 257: 9692 (1982). (10.1016/S0021-9258(18)34128-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1982)
  19. GLOBUS, M, NEUROTROPHIC CONTRIBUTION TO A PROPOSED TRIPARTITE CONTROL OF THE MITOTIC-CYCLE IN THE REGENERATION BLASTEMA OF THE NEWT, NOTOPHTHALMUS-(TRITURUS)-VIRIDESCENS, AMERICAN ZOOLOGIST 18: 855 (1978). (10.1093/icb/18.4.855) / AMERICAN ZOOLOGIST (1978)
  20. GLOBUS, M, EFFECT OF APICAL EPIDERMAL CAP ON MITOTIC-CYCLE AND CARTILAGE DIFFERENTIATION IN REGENERATION BLASTEMATA IN THE NEWT, NOTOPHTHALMUS-VIRIDESCENS, DEVELOPMENTAL BIOLOGY 75: 358 (1980). (10.1016/0012-1606(80)90169-4) / DEVELOPMENTAL BIOLOGY (1980)
  21. GLOBUS, M, TRANSFILTER MITOGENIC EFFECT OF DORSAL ROOT-GANGLIA ON CULTURED REGENERATION BLASTEMATA, IN NEWT, NOTOPHTHALMUS-VIRIDESCENS, DEVELOPMENTAL BIOLOGY 56: 316 (1977). (10.1016/0012-1606(77)90273-1) / DEVELOPMENTAL BIOLOGY (1977)
  22. GLOBUS M LIMB DEV REGENERATIO (1983).
  23. GOSPODAROWICZ, D, ADV METAB DISORD 8: 301 (1975). (10.1016/B978-0-12-027308-9.50026-3) / ADV METAB DISORD (1975)
  24. GOSPODAROWICZ, D, ANN NY ACAD SCI 339: 151 (1980). (10.1111/j.1749-6632.1980.tb15976.x) / ANN NY ACAD SCI (1980)
  25. GOSPODAROWICZ, D, PURIFICATION IN HIGH-YIELD OF BRAIN FIBROBLAST GROWTH-FACTOR BY PREPARATIVE ISOELECTRIC-FOCUSING AT PH 9.6, JOURNAL OF BIOLOGICAL CHEMISTRY 257: 12266 (1982). (10.1016/S0021-9258(18)33710-4) / JOURNAL OF BIOLOGICAL CHEMISTRY (1982)
  26. GOSPODAROWICZ, D, PURIFICATION OF FIBROBLAST GROWTH-FACTOR ACTIVITY FROM BOVINE BRAIN, JOURNAL OF BIOLOGICAL CHEMISTRY 253: 3736 (1978). (10.1016/S0021-9258(17)34863-9) / JOURNAL OF BIOLOGICAL CHEMISTRY (1978)
  27. GOSPODAROWICZ, D, LOCALIZATION OF A FIBROBLAST GROWTH-FACTOR AND ITS EFFECT ALONE AND WITH HYDROCORTISONE ON 3T3 CELL-GROWTH, NATURE 249: 123 (1974). (10.1038/249123a0) / NATURE (1974)
  28. GOSS R.J. PRINCIPLES REGENERAT (1969).
  29. GUYENOT, E, Demonstration of the existance of specific regeneration areas by the method of deviation of nerve trunks, COMPTES RENDUS DES SEANCES DE LA SOCIETE DE BIOLOGIE ET DE SES FILIALES 94: 1050 (1926). / COMPTES RENDUS DES SEANCES DE LA SOCIETE DE BIOLOGIE ET DE SES FILIALES (1926)
  30. GUYENOT, E, C R SEANCES SOC PHYS 43: 32 (1926). / C R SEANCES SOC PHYS (1926)
  31. GUYENOT, E, REVUE SUISSE DE ZOOLOGIE 55 2: 1 (1948). / REVUE SUISSE DE ZOOLOGIE (1948)
  32. HAY, E.D., ELECTRON MICROSCOPIC OBSERVATIONS OF MUSCLE DEDIFFERENTIATION IN REGENERATING AMBLYSTOMA LIMBS, DEVELOPMENTAL BIOLOGY 1: 555 (1959). (10.1016/0012-1606(59)90018-1) / DEVELOPMENTAL BIOLOGY (1959)
  33. ITEN, L.E., WILHELM ROUX ARCH EN 173: 263 (1973). (10.1007/BF00575834) / WILHELM ROUX ARCH EN (1973)
  34. KATO, T, GLIA MATURATION FACTOR IN BOVINE BRAIN - PARTIAL-PURIFICATION AND PHYSICOCHEMICAL CHARACTERIZATION, BRAIN RESEARCH 212: 393 (1981). (10.1016/0006-8993(81)90471-6) / BRAIN RESEARCH (1981)
  35. KELLETT, J.G., THE CHARACTERIZATION OF GROWTH-FACTOR ACTIVITY IN HUMAN-BRAIN, JOURNAL OF BIOLOGICAL CHEMISTRY 256: 54 (1981). (10.1016/S0021-9258(19)70096-9) / JOURNAL OF BIOLOGICAL CHEMISTRY (1981)
  36. KIM, S.U., CULTURE OF PURIFIED RAT ASTROCYTES IN SERUM-FREE MEDIUM SUPPLEMENTED WITH MITOGEN, BRAIN RESEARCH 274: 79 (1983). (10.1016/0006-8993(83)90522-X) / BRAIN RESEARCH (1983)
  37. Kintner C. R. Molecular Bases of Neural Development (1984).
  38. KINTNER, C.R., MONOCLONAL-ANTIBODIES IDENTIFY BLASTEMAL CELLS DERIVED FROM DEDIFFERENTIATING MUSCLE IN NEWT LIMB REGENERATION, NATURE 308: 67 (1984). (10.1038/308067a0) / NATURE (1984)
  39. KINTNER C.R. unpublished data.
  40. KONIGSBERG, U.R., REGENERATIVE RESPONSE OF SINGLE MATURE MUSCLE-FIBERS ISOLATED INVITRO, DEVELOPMENTAL BIOLOGY 45: 260 (1975). (10.1016/0012-1606(75)90065-2) / DEVELOPMENTAL BIOLOGY (1975)
  41. LEMKE, G.E., IDENTIFICATION AND PURIFICATION OF GLIAL GROWTH-FACTOR, JOURNAL OF NEUROSCIENCE 4: 75 (1984). (10.1523/JNEUROSCI.04-01-00075.1984) / JOURNAL OF NEUROSCIENCE (1984)
  42. LEMKE G.E. THESIS CALTECH (1983).
  43. LEMMON, S.K., PURIFICATION AND PARTIAL CHARACTERIZATION OF BOVINE PITUITARY FIBROBLAST GROWTH-FACTOR, JOURNAL OF CELLULAR BIOCHEMISTRY 21: 195 (1983). (10.1002/jcb.240210302) / JOURNAL OF CELLULAR BIOCHEMISTRY (1983)
  44. LEMMON, S.K., BOVINE FIBROBLAST GROWTH-FACTOR - COMPARISON OF BRAIN AND PITUITARY PREPARATIONS, JOURNAL OF CELL BIOLOGY 95: 162 (1982). (10.1083/jcb.95.1.162) / JOURNAL OF CELL BIOLOGY (1982)
  45. LENTZ, T.L., CYTOLOGICAL STUDIES OF MUSCLE DEDIFFERENTIATION AND DIFFERENTIATION DURING LIMB REGENERATION OF NEWT TRITURUS, AMERICAN JOURNAL OF ANATOMY 124: 447 (1969). (10.1002/aja.1001240404) / AMERICAN JOURNAL OF ANATOMY (1969)
  46. LEVIMONTALCINI, R, DESTRUCTION OF THE SYMPATHETIC GANGLIA IN MAMMALS BY AN ANTISERUM TO A NERVE-GROWTH PROTEIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 46: 384 (1960). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1960)
  47. LOCATELLI, P, ARCH SCI BIOL 7: 300 (1925). / ARCH SCI BIOL (1925)
  48. MACIAG, T, JOURNAL OF BIOLOGICAL CHEMISTRY 257: 5333 (1982). (10.1016/S0021-9258(19)83778-X) / JOURNAL OF BIOLOGICAL CHEMISTRY (1982)
  49. MADEN, M, ROLE OF SCHWANN-CELLS IN PARADOXICAL REGENERATION IN AXOLOTL, JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY 41: 1 (1977). / JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY (1977)
  50. MADEN, M, NEUROTROPHIC CONTROL OF THE CELL-CYCLE DURING AMPHIBIAN LIMB REGENERATION, JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY 48: 169 (1978). / JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY (1978)
  51. MCCARTHY, K.D., PREPARATION OF PURE NEURONAL AND NON-NEURONAL CULTURES FROM EMBRYONIC CHICK SYMPATHETIC-GANGLIA - NEW METHOD BASED ON BOTH DIFFERENTIAL CELL ADHESIVENESS AND FORMATION OF HOMOTYPIC NEURONAL AGGREGATES, BRAIN RESEARCH 114: 391 (1976). (10.1016/0006-8993(76)90962-8) / BRAIN RESEARCH (1976)
  52. MCCARTHY, K.D., NEURONAL STIMULATION OF [H-3]THYMIDINE INCORPORATION BY PRIMARY CULTURES OF HIGHLY PURIFIED NON-NEURONAL CELLS, BRAIN RESEARCH 114: 415 (1976). (10.1016/0006-8993(76)90963-X) / BRAIN RESEARCH (1976)
  53. MESCHER, A.L., DENERVATION EFFECTS ON DNA-REPLICATION AND MITOSIS DURING INITIATION OF LIMB REGENERATION IN ADULT NEWTS, DEVELOPMENTAL BIOLOGY 44: 187 (1975). (10.1016/0012-1606(75)90386-3) / DEVELOPMENTAL BIOLOGY (1975)
  54. MESCHER, A.L., NEWT FORELIMB REGENERATION BLASTEMAS INVITRO - CELLULAR-RESPONSE TO EXPLANTATION AND EFFECTS OF VARIOUS GROWTH-PROMOTING SUBSTANCES, JOURNAL OF EXPERIMENTAL ZOOLOGY 216: 235 (1981). (10.1002/jez.1402160204) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1981)
  55. MORRISON, R.S., DEVELOPMENTAL EXPRESSION OF RAT-BRAIN MITOGENS FOR CULTURED ASTROCYTES, JOURNAL OF NEUROSCIENCE RESEARCH 8: 435 (1982). (10.1002/jnr.490080231) / JOURNAL OF NEUROSCIENCE RESEARCH (1982)
  56. NEWMARK, P, AN EMBARRASSMENT OF PEPTIDES, NATURE 303: 655 (1983). (10.1038/303655a0) / NATURE (1983)
  57. PETTMANN, B, ISOLATION OF A GLIAL MATURATION FACTOR FROM BEEF BRAIN, FEBS LETTERS 118: 195 (1980). (10.1016/0014-5793(80)80217-1) / FEBS LETTERS (1980)
  58. RAFF, M.C., SCHWANN CELL-GROWTH FACTORS, CELL 15: 813 (1978). (10.1016/0092-8674(78)90266-0) / CELL (1978)
  59. ROZENGURT, E, VASOPRESSIN STIMULATION OF MOUSE 3T3-CELL GROWTH, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 1284 (1979). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1979)
  60. Rozengurt, E., Proceedings of the National Academy of Sciences of the United States of America 80: 2936 (1983). / Proceedings of the National Academy of Sciences of the United States of America (1983)
  61. SALZER, J.L., STUDIES OF SCHWANN-CELL PROLIFERATION .1. ANALYSIS IN TISSUE-CULTURE OF PROLIFERATION DURING DEVELOPMENT, WALLERIAN DEGENERATION, AND DIRECT INJURY, JOURNAL OF CELL BIOLOGY 84: 739 (1980). (10.1083/jcb.84.3.739) / JOURNAL OF CELL BIOLOGY (1980)
  62. SALZER, J.L., STUDIES OF SCHWANN-CELL PROLIFERATION .2. CHARACTERIZATION OF THE STIMULATION AND SPECIFICITY OF THE RESPONSE TO A NEURITE MEMBRANE-FRACTION, JOURNAL OF CELL BIOLOGY 84: 753 (1980). (10.1083/jcb.84.3.753) / JOURNAL OF CELL BIOLOGY (1980)
  63. SALZER, J.L., STUDIES OF SCHWANN-CELL PROLIFERATION .3. EVIDENCE FOR THE SURFACE LOCALIZATION OF THE NEURITE MITOGEN, JOURNAL OF CELL BIOLOGY 84: 767 (1980). (10.1083/jcb.84.3.767) / JOURNAL OF CELL BIOLOGY (1980)
  64. SCHALLER H.C. CURRENT METHODS CELL (1983).
  65. SIDMAN, R.L., LIMB REGENERATION WITHOUT INNERVATION OF THE APICAL EPIDERMIS IN THE ADULT NEWT, TRITURUS, JOURNAL OF EXPERIMENTAL ZOOLOGY 144: 105 (1960). (10.1002/jez.1401440202) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1960)
  66. SINGER, M, NEUROTROPHIC CONTROL OF LIMB REGENERATION IN NEWT, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 228: 308 (1974). (10.1111/j.1749-6632.1974.tb20520.x) / ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (1974)
  67. SINGER, M, THE NERVOUS SYSTEM AND REGENERATION OF THE FORELIMB OF ADULT TRITURUS .6. A FURTHER STUDY OF THE IMPORTANCE OF NERVE NUMBER, INCLUDING QUANTITATIVE MEASUREMENTS OF LIMB INNERVATION, JOURNAL OF EXPERIMENTAL ZOOLOGY 104: 223 (1947). (10.1002/jez.1401040204) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1947)
  68. SINGER, M, THE GROWTH AND MORPHOGENESIS OF THE REGENERATING FORELIMB OF ADULT TRITURUS FOLLOWING DENERVATION AT VARIOUS STAGES OF DEVELOPMENT, JOURNAL OF EXPERIMENTAL ZOOLOGY 108: 279 (1948). (10.1002/jez.1401080207) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1948)
  69. SINGER, M, RELATION BETWEEN CALIBER OF AXON AND TROPHIC ACTIVITY OF NERVES IN LIMB REGENERATION, JOURNAL OF EXPERIMENTAL ZOOLOGY 166: 89 (1967). (10.1002/jez.1401660110) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1967)
  70. SINGER, M, The nervous system and regeneration of the forelimb of adult Triturus II. The role of the sensory supply, JOURNAL OF EXPERIMENTAL ZOOLOGY 92: 297 (1943). (10.1002/jez.1400920305) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1943)
  71. SINGER, M, NEUROTROPHIC ACTIVITY OF BRAIN EXTRACTS IN FORELIMB REGENERATION OF URODELE, TRITURUS, JOURNAL OF EXPERIMENTAL ZOOLOGY 196: 131 (1976). (10.1002/jez.1401960202) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1976)
  72. SINGER, M, THE NERVOUS SYSTEM AND REGENERATION OF THE FORELIMB OF ADULT TRITURUS .5. THE INFLUENCE OF NUMBER OF NERVE FIBERS, INCLUDING A QUANTITATIVE STUDY OF LIMB INNERVATION, JOURNAL OF EXPERIMENTAL ZOOLOGY 101: 299 (1946). (10.1002/jez.1401010303) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1946)
  73. SINGER, M, QUART REV BIOL 27: 169 (1952). / QUART REV BIOL (1952)
  74. SINGER M REGENERATION ANIMALS (1965).
  75. SMITH, A.R., NERVES AND ANGIOGENESIS IN AMPHIBIAN LIMB REGENERATION, NATURE 257: 224 (1975). (10.1038/257224a0) / NATURE (1975)
  76. SOBUE, G, SPECIFIC AND POTENT MITOGENIC EFFECT OF AXOLEMMAL FRACTION ON SCHWANN-CELLS FROM RAT SCIATIC-NERVES IN SERUM-CONTAINING AND DEFINED MEDIA, BRAIN RESEARCH 280: 263 (1983). (10.1016/0006-8993(83)90056-2) / BRAIN RESEARCH (1983)
  77. TASSAVA, R.A., NEURAL CONTROL OF CELL-CYCLE EVENTS IN REGENERATING SALAMANDER LIMBS, AMERICAN ZOOLOGIST 18: 843 (1978). (10.1093/icb/18.4.843) / AMERICAN ZOOLOGIST (1978)
  78. THOMAS, K.A., BRAIN FIBROBLAST GROWTH-FACTOR - NONIDENTITY WITH MYELIN BASIC-PROTEIN FRAGMENTS, JOURNAL OF BIOLOGICAL CHEMISTRY 255: 5517 (1980). (10.1016/S0021-9258(19)70659-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1980)
  79. Thomas, K. A., Proceedings of the National Academy of Sciences of the United States of America 81: 357 (1984). / Proceedings of the National Academy of Sciences of the United States of America (1984)
  80. THORNTON, C.S., RECUPERATION OF REGENERATION IN DENERVATED LIMBS OF AMBYSTOMA LARVAE, JOURNAL OF EXPERIMENTAL ZOOLOGY 173: 293 (1970). (10.1002/jez.1401730308) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1970)
  81. THORNTON, C.S., The histogenesis of muscle in the regenerating fore limb of larval Amblystoma punctatum, JOURNAL OF MORPHOLOGY 62: 17 (1938). (10.1002/jmor.1050620104) / JOURNAL OF MORPHOLOGY (1938)
  82. TODARO, G.J., QUANTITATIVE STUDIES OF GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES, JOURNAL OF CELL BIOLOGY 17: 299 (1963). (10.1083/jcb.17.2.299) / JOURNAL OF CELL BIOLOGY (1963)
  83. TRAMPUSCH A.L. REGENERATION ANIMALS (1965).
  84. WALLACE, H, COMPONENTS OF REGROWING NERVES WHICH SUPPORT REGENERATION OF IRRADIATED SALAMANDER LIMBS, JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY 28: 419 (1972). / JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY (1972)
  85. WALLACE H VERTEBRATE LIMB REGE (1981).
  86. WESTALL, F.C., BRAIN-DERIVED FIBROBLAST GROWTH-FACTOR - IDENTITY WITH A FRAGMENT OF BASIC-PROTEIN OF MYELIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75: 4675 (1978). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1978)
  87. WOOD, P.M., SEPARATION OF FUNCTIONAL SCHWANN-CELLS AND NEURONS FROM NORMAL PERIPHERAL-NERVE TISSUE, BRAIN RESEARCH 115: 361 (1976). (10.1016/0006-8993(76)90355-3) / BRAIN RESEARCH (1976)
  88. WOOD, P.M., NATURE 256: 661 (1975). (10.1038/256661a0) / NATURE (1975)
  89. YNTEMA, C.L., REGENERATION IN SPARSELY INNERVATED AND ANEUROGENIC FORELIMBS OF AMBLYSTOMA LARVAE, JOURNAL OF EXPERIMENTAL ZOOLOGY 140: 101 (1959). (10.1002/jez.1401400106) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1959)
  90. YNTEMA, C.L., BLASTEMA FORMATION IN SPARSELY INNERVATED AND ANEUROGENIC FORELIMBS OF AMBLYSTOMA LARVAE, JOURNAL OF EXPERIMENTAL ZOOLOGY 142: 423 (1959). (10.1002/jez.1401420119) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1959)
Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 3:41 p.m.)
Deposited 1 year, 7 months ago (Jan. 14, 2024, 4:53 p.m.)
Indexed 3 months, 2 weeks ago (May 9, 2025, 2:04 p.m.)
Issued 40 years, 11 months ago (Sept. 21, 1984)
Published 40 years, 11 months ago (Sept. 21, 1984)
Published Print 40 years, 11 months ago (Sept. 21, 1984)
Funders 0

None

@article{Brockes_1984, title={Mitogenic Growth Factors and Nerve Dependence of Limb Regeneration}, volume={225}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6474177}, DOI={10.1126/science.6474177}, number={4668}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Brockes, Jeremy P.}, year={1984}, month=sep, pages={1280–1287} }