DOI: 10.1126/science.6474172. Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

10.1126/science.6474172

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex. The affected cells are precisely those that interconnect the hippocampal formation with the association cortices, basal forebrain, thalamus, and hypothalamus, structures crucial to memory. This focal pattern of pathology isolates the hippocampal formation from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.

Bibliography

Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984). Alzheimerâs Disease: Cell-Specific Pathology Isolates the Hippocampal Formation. Science, 225(4667), 1168â1170.

Authors 4

Bradley T. Hyman (first)
Gary W. Van Hoesen (additional)
Antonio R. Damasio (additional)
Clifford L. Barnes (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:41 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:54 p.m.)
Indexed	9 hours, 34 minutes ago (Aug. 29, 2025, 6:20 a.m.)
Issued	40 years, 11 months ago (Sept. 14, 1984)
Published	40 years, 11 months ago (Sept. 14, 1984)
Published Print	40 years, 11 months ago (Sept. 14, 1984)

Funders 0

None

BibTeX

@article{Hyman_1984, title={Alzheimer’s Disease: Cell-Specific Pathology Isolates the Hippocampal Formation}, volume={225}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6474172}, DOI={10.1126/science.6474172}, number={4667}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Hyman, Bradley T. and Van Hoesen, Gary W. and Damasio, Antonio R. and Barnes, Clifford L.}, year={1984}, month=sep, pages={1168–1170} }

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