DOI: 10.1126/science.6474166. Neurons Generated in the Adult Brain Are Recruited into Functional Circuits

Neurons Generated in the Adult Brain Are Recruited into Functional Circuits

10.1126/science.6474166

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Adult canaries, Serinus canarius , received injections of 3 H-labeled thymidine, a marker of DNA synthesis. Thirty days after the last injection, intracellular potentials were recorded from neurons in the nucleus hyperstriatum ventralis pars caudalis, a vocal control nucleus in the telencephalon; these same cells were then injected with horseradish peroxidase. Of the 74 neurons labeled with horseradish peroxidase that were recovered, the nuclei of seven were radioactively labeled. Four of these seven neurons had responded to auditory stimuli. These double-labeled neurons were apparently generated during or after the 3 H-labeled thymidine treatment (during adulthood) and subsequently incorporated into functional neural circuits.

Bibliography

Paton, J. A., & Nottebohm, F. N. (1984). Neurons Generated in the Adult Brain Are Recruited into Functional Circuits. Science, 225(4666), 1046â1048.

Authors 2

John A. Paton (first)
Fernando N. Nottebohm (additional)

References 27 Referenced 339

ALTMAN, J, DEV NEUROBIOL: 192 (1970). / DEV NEUROBIOL (1970)
10.1126/science.135.3509.1127
BAYER, S.A., CHANGES IN THE TOTAL NUMBER OF DENTATE GRANULE CELLS IN JUVENILE AND ADULT-RATS - A CORRELATED VOLUMETRIC AND H-3-LABELED 3-THYMIDINE AUTORADIOGRAPHIC STUDY, EXPERIMENTAL BRAIN RESEARCH 46: 315 (1982). (10.1007/BF00238626) / EXPERIMENTAL BRAIN RESEARCH (1982)
10.1126/science.7079742
BIRSE, S.C., NEURONAL INCREASE IN VARIOUS AREAS OF THE NERVOUS-SYSTEM OF THE GUPPY, LEBISTES, JOURNAL OF COMPARATIVE NEUROLOGY 194: 291 (1980). (10.1002/cne.901940202) / JOURNAL OF COMPARATIVE NEUROLOGY (1980)
COWAN, W.M., INT REV PHYSL NEUROP 17: 149 (1978). / INT REV PHYSL NEUROP (1978)
10.1126/science.7280692
EASTER, S.S., POSTNATAL NEUROGENESIS AND CHANGING CONNECTIONS, TRENDS IN NEUROSCIENCES 6: 53 (1983). (10.1016/0166-2236(83)90025-5) / TRENDS IN NEUROSCIENCES (1983)
Goldman, S. A., Proceedings of the National Academy of Sciences of the United States of America 80: 2390 (1983). / Proceedings of the National Academy of Sciences of the United States of America (1983)
HENRIKSON, C.K., FINE-STRUCTURAL RELATIONSHIPS BETWEEN NEURITES AND RADIAL GLIAL PROCESSES IN DEVELOPING MOUSE SPINAL-CORD, JOURNAL OF NEUROCYTOLOGY 3: 659 (1974). (10.1007/BF01097190) / JOURNAL OF NEUROCYTOLOGY (1974)
JACOBSON, M, DEV NEUROBIOL: 27 (1978). / DEV NEUROBIOL (1978)
KAPLAN, M.S., NEURONAL PROLIFERATION IN THE 9-MONTH-OLD RODENT - AUTORADIOGRAPHIC STUDY OF GRANULE CELLS IN THE HIPPOCAMPUS, EXPERIMENTAL BRAIN RESEARCH 52: 1 (1983). / EXPERIMENTAL BRAIN RESEARCH (1983)
KAPLAN, M.S., NEUROGENESIS IN THE 3-MONTH-OLD RAT VISUAL-CORTEX, JOURNAL OF COMPARATIVE NEUROLOGY 195: 323 (1981). (10.1002/cne.901950211) / JOURNAL OF COMPARATIVE NEUROLOGY (1981)
10.1126/science.887941
KATZ, L.C., AUDITORY RESPONSES IN THE ZEBRA FINCHS MOTOR SYSTEM FOR SONG, BRAIN RESEARCH 221: 192 (1981). (10.1016/0006-8993(81)91073-8) / BRAIN RESEARCH (1981)
KORR, H, ADVANCES IN ANATOMY EMBRYOLOGY AND CELL BIOLOGY 61: 1 (1980). (10.1007/978-3-642-67577-5_1) / ADVANCES IN ANATOMY EMBRYOLOGY AND CELL BIOLOGY (1980)
MALMGREN, L, SENSITIVE METHOD FOR HISTOCHEMICAL DEMONSTRATION OF HORSERADISH-PEROXIDASE IN NEURONS FOLLOWING RETROGRADE AXONAL-TRANSPORT, BRAIN RESEARCH 148: 279 (1978). (10.1016/0006-8993(78)90720-5) / BRAIN RESEARCH (1978)
MARGOLIASH, D, ACOUSTIC PARAMETERS UNDERLYING THE RESPONSES OF SONG-SPECIFIC NEURONS IN THE WHITE-CROWNED SPARROW, JOURNAL OF NEUROSCIENCE 3: 1039 (1983). (10.1523/JNEUROSCI.03-05-01039.1983) / JOURNAL OF NEUROSCIENCE (1983)
McCasland, J. S., Proceedings of the National Academy of Sciences of the United States of America 78: 7815 (1981). / Proceedings of the National Academy of Sciences of the United States of America (1981)
NOTTEBOHM, F, TESTOSTERONE TRIGGERS GROWTH OF BRAIN VOCAL CONTROL NUCLEI IN ADULT FEMALE CANARIES, BRAIN RESEARCH 189: 429 (1980). (10.1016/0006-8993(80)90102-X) / BRAIN RESEARCH (1980)
NOTTEBOHM, F, CENTRAL CONTROL OF SONG IN CANARY, SERINUS-CANARIUS, JOURNAL OF COMPARATIVE NEUROLOGY 165: 457 (1976). (10.1002/cne.901650405) / JOURNAL OF COMPARATIVE NEUROLOGY (1976)
10.1126/science.7313697
NOTTEBOHM, F, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 9: 380 (1983). / SOCIETY FOR NEUROSCIENCE. ABSTRACTS (1983)
OPPENHEIM, R.W., CELL-DEATH OF MOTONEURONS IN CHICK-EMBRYO SPINAL-CORD .3. DIFFERENTIATION OF MOTONEURONS PRIOR TO THEIR INDUCED DEGENERATION FOLLOWING LIMB-BUD REMOVAL, JOURNAL OF COMPARATIVE NEUROLOGY 177: 87 (1978). (10.1002/cne.901770107) / JOURNAL OF COMPARATIVE NEUROLOGY (1978)
PATON J.A. unpublished data.
SIDMAN, R.L., CONT RES METHODS NEU: 252 (1970). / CONT RES METHODS NEU (1970)
WOLFF, J.R., AXO-GLIAL SYNAPSES AND GABA-ACCUMULATING GLIAL-CELLS IN THE EMBRYONIC NEOCORTEX OF THE RAT, CELL AND TISSUE RESEARCH 201: 239 (1979). / CELL AND TISSUE RESEARCH (1979)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 3:41 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:55 p.m.)
Indexed	2 days, 14 hours ago (Sept. 3, 2025, 6:43 a.m.)
Issued	40 years, 11 months ago (Sept. 7, 1984)
Published	40 years, 11 months ago (Sept. 7, 1984)
Published Print	40 years, 11 months ago (Sept. 7, 1984)

Funders 0

None

BibTeX

@article{Paton_1984, title={Neurons Generated in the Adult Brain Are Recruited into Functional Circuits}, volume={225}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6474166}, DOI={10.1126/science.6474166}, number={4666}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Paton, John A. and Nottebohm, Fernando N.}, year={1984}, month=sep, pages={1046–1048} }

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