DOI: 10.1126/science.6435246. Chromosomal Location of Human T-Cell Receptor Gene T <sub>i</sub> β

Chromosomal Location of Human T-Cell Receptor Gene T i β

10.1126/science.6435246

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A complementary DNA probe corresponding to the β-chain gene of T i , the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the T i β gene was determined with the complementary DNA by screening a series of 12 cell hybrid (mouse × human) DNA's containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human T i β gene resides on chromosome 7 and is thus not linked to the immunoglobulin loci or to the major histocompatibility locus in humans.

Authors 5

P. E. Barker (first)
Frank H. Ruddle (additional)
Hans-Dieter Royer (additional)
Oreste Acuto (additional)
Ellis L. Reinherz (additional)

References 23 Referenced 33

ACUTO, O, THE HUMAN T-CELL RECEPTOR - APPEARANCE IN ONTOGENY AND BIOCHEMICAL RELATIONSHIP OF ALPHA-SUBUNITS AND BETA-SUBUNITS ON IL-2 DEPENDENT CLONES AND T-CELL TUMORS, CELL 34: 717 (1983). (10.1016/0092-8674(83)90528-7) / CELL (1983)
ACUTO, O, PURIFICATION AND NH2-TERMINAL AMINO-ACID SEQUENCING OF THE BETA-SUBUNIT OF A HUMAN T-CELL ANTIGEN RECEPTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 3851 (1984). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1984)
Barker, P. E., Proceedings of the National Academy of Sciences of the United States of America 81: 5826 (1984). / Proceedings of the National Academy of Sciences of the United States of America (1984)
CROCE, C.M., PREFERENTIAL RETENTION OF HUMAN CHROMOSOME C-7 IN HUMAN-(THYMIDINE KINASE DEFICIENT) MOUSE HYBRID CELLS, EXPERIMENTAL CELL RESEARCH 82: 457 (1973). (10.1016/0014-4827(73)90366-2) / EXPERIMENTAL CELL RESEARCH (1973)
CROCE, C.M., CHROMOSOMAL LOCATION OF THE GENES FOR HUMAN-IMMUNOGLOBULIN HEAVY-CHAINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 3416 (1979). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1979)
DELACHAPELLE, A, CYTOGENETICS AND CELL GENETICS 37: 436 (1984). / CYTOGENETICS AND CELL GENETICS (1984)
10.1038/308149a0
KAPPLER, J, THE MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED ANTIGEN RECEPTOR ON T-CELLS IN MOUSE AND MAN .5. IDENTIFICATION OF CONSTANT AND VARIABLE PEPTIDES, CELL 35: 295 (1983). (10.1016/0092-8674(83)90232-5) / CELL (1983)
Maniatis, T., Molecular Cloning: A Laboratory Manual: 113 (1982). / Molecular Cloning: A Laboratory Manual (1982)
MCINTYRE, B.W., THE MOUSE T-CELL RECEPTOR - STRUCTURAL HETEROGENEITY OF MOLECULES OF NORMAL T-CELLS DEFINED BY XENOANTISERUM, CELL 34: 739 (1983). (10.1016/0092-8674(83)90530-5) / CELL (1983)
MEUER, S.C., EVIDENCE FOR THE T3-ASSOCIATED 90K HETERODIMER AS THE T-CELL ANTIGEN RECEPTOR, NATURE 303: 808 (1983). (10.1038/303808a0) / NATURE (1983)
10.1126/science.6606228
MITELMAN, F, CYTOGENET CELL GENET 36: 124 (1983). (10.1159/000131938) / CYTOGENET CELL GENET (1983)
MORTON, C. C., AMERICAN JOURNAL OF HUMAN GENETICS 34: A136 (1982). / AMERICAN JOURNAL OF HUMAN GENETICS (1982)
RABBITTS, T.H., THE HUMAN-IMMUNOGLOBULIN GENES, BIOCHEMICAL SOCIETY TRANSACTIONS 11: 119 (1983). (10.1042/bst0110119) / BIOCHEMICAL SOCIETY TRANSACTIONS (1983)
ROUSSEL, M.F., MOLECULAR-CLONING OF THE C-FMS LOCUS AND ITS ASSIGNMENT TO HUMAN CHROMOSOME-5, JOURNAL OF VIROLOGY 48: 770 (1983). (10.1128/jvi.48.3.770-773.1983) / JOURNAL OF VIROLOGY (1983)
Royer, H. D., Journal of Experimental Medicine 160: 947 (1984). (10.1084/jem.160.3.947) / Journal of Experimental Medicine (1984)
ROYER H.D. unpublished data.
RYAN, J, CHROMOSOMAL ASSIGNMENT OF A FAMILY OF HUMAN ONCOGENES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80: 4460 (1983). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1983)
10.1016/S0022-2836(75)80083-0
SPURR, N.K., CHROMOSOMAL LOCALIZATION OF THE HUMAN HOMOLOGS TO THE ONCOGENE-ERBA AND ONCOGENE-ERBB, EMBO JOURNAL 3: 159 (1984). (10.1002/j.1460-2075.1984.tb01777.x) / EMBO JOURNAL (1984)
YANAGI, Y, A HUMAN T-CELL-SPECIFIC CDNA CLONE ENCODES A PROTEIN HAVING EXTENSIVE HOMOLOGY TO IMMUNOGLOBULIN-CHAINS, NATURE 308: 145 (1984). (10.1038/308145a0) / NATURE (1984)
10.1126/science.6336310

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:41 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 6:19 p.m.)
Indexed	4 months, 2 weeks ago (April 8, 2025, 10:19 p.m.)
Issued	40 years, 10 months ago (Oct. 19, 1984)
Published	40 years, 10 months ago (Oct. 19, 1984)
Published Print	40 years, 10 months ago (Oct. 19, 1984)

Funders 0

None

BibTeX

@article{Barker_1984, title={Chromosomal Location of Human T-Cell Receptor Gene T i β}, volume={226}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6435246}, DOI={10.1126/science.6435246}, number={4672}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Barker, P. E. and Ruddle, Frank H. and Royer, Hans-Dieter and Acuto, Oreste and Reinherz, Ellis L.}, year={1984}, month=oct, pages={348–349} }

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