DOI: 10.1126/science.6420886. Inhibitors of Poly(Adenosine Diphosphate-Ribose) Synthesis: Effect on Other Metabolic Processes

Inhibitors of Poly(Adenosine Diphosphate-Ribose) Synthesis: Effect on Other Metabolic Processes

10.1126/science.6420886

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

3-Aminobenzamide and benzamide, purported to be specific inhibitors of the synthesis of poly(adenosine diphosphate-ribose), were used to elucidate possible functions of this biopolymer. These compounds, at frequently used experimental concentrations, not only inhibited the action of poly(adenosine diphosphate-ribose) synthetase but also affected cell viability, glucose metabolism, and DNA synthesis. Thus, the usefulness of 3-aminobenzamide and benzamide may be severely restricted by the difficulty of finding a dose small enough to inhibit the synthetase without producing additional metabolic effects.

Bibliography

Milam, K. M., & Cleaver, J. E. (1984). Inhibitors of Poly(Adenosine Diphosphate-Ribose) Synthesis: Effect on Other Metabolic Processes. Science, 223(4636), 589â591.

Authors 2

Kathryn M. Milam (first)
James E. Cleaver (additional)

References 41 Referenced 191

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:41 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 6:08 p.m.)
Indexed	1 month, 1 week ago (July 24, 2025, 6:51 a.m.)
Issued	41 years, 6 months ago (Feb. 10, 1984)
Published	41 years, 6 months ago (Feb. 10, 1984)
Published Print	41 years, 6 months ago (Feb. 10, 1984)

Funders 0

None

BibTeX

@article{Milam_1984, title={Inhibitors of Poly(Adenosine Diphosphate-Ribose) Synthesis: Effect on Other Metabolic Processes}, volume={223}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6420886}, DOI={10.1126/science.6420886}, number={4636}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Milam, Kathryn M. and Cleaver, James E.}, year={1984}, month=feb, pages={589–591} }

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