DOI: 10.1126/science.6344214. Splice Junctions: Association with Variation in Protein Structure

Splice Junctions: Association with Variation in Protein Structure

10.1126/science.6344214

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A comparison between eukaryotic gene sequences and protein sequences of homologous enzymes from bacterial and mammalian organisms shows that intron-exon junctions frequently coincide with variable surface loops of the protein structures. The altered surface structures can account for functional differences among the members of a family. Sliding of the intron-exon junctions may constitute one mechanism for generating length polymorphisms and divergent sequences found in protein families. Since intron-exon junctions map to protein surfaces, the alterations mediated by sliding of these junctions can be effected without disrupting the stability of the protein core.

Bibliography

Craik, C. S., Rutter, W. J., & Fletterick, R. (1983). Splice Junctions: Association with Variation in Protein Structure. Science, 220(4602), 1125â1129.

Authors 3

Charles S. Craik (first)
William J. Rutter (additional)
Robert Fletterick (additional)

References 48 Referenced 190

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 2:37 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:38 p.m.)
Indexed	2 weeks, 6 days ago (Aug. 5, 2025, 8:45 a.m.)
Issued	42 years, 2 months ago (June 10, 1983)
Published	42 years, 2 months ago (June 10, 1983)
Published Print	42 years, 2 months ago (June 10, 1983)

Funders 0

None

BibTeX

@article{Craik_1983, title={Splice Junctions: Association with Variation in Protein Structure}, volume={220}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6344214}, DOI={10.1126/science.6344214}, number={4602}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Craik, Charles S. and Rutter, William J. and Fletterick, Robert}, year={1983}, month=jun, pages={1125–1129} }

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