DOI: 10.1126/science.6332378. Pargyline Prevents MPTP-Induced Parkinsonism in Primates

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

10.1126/science.6332378

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin which produces permanent parkinsonism in human and nonhuman primates. Treatment of squirrel monkeys with pargyline, a monoamine oxidase (MAO) inhibitor, prevents both clinical and neuropathological evidence of the neurotoxic effects of MPTP. Pargyline also inhibits conversion of MPTP to 1-methyl-4-phenylpyridinium ion (MPP + ), a metabolic step that occurs rapidly after administration of MPTP in animals not treated with pargyline. It is proposed that the conversion of MPTP to MPP+, possibly involving MAO, may be important for the neurotoxic effects of MPTP to take place, and MPTP itself may not be the neurotoxic agent.

Bibliography

Langston, J. W., Irwin, I., Langston, E. B., & Forno, L. S. (1984). Pargyline Prevents MPTP-Induced Parkinsonism in Primates. Science, 225(4669), 1480â1482.

Authors 4

J. William Langston (first)
Ian Irwin (additional)
Elizabeth B. Langston (additional)
Lysia S. Forno (additional)

References 12 Referenced 522

BIRKMAYER, W, PHARMACOPSYCHITARY 19: 170 (1983). / PHARMACOPSYCHITARY (1983)
Burns, R. S., Proceedings of the National Academy of Sciences of the United States of America 80: 4546 (1983). / Proceedings of the National Academy of Sciences of the United States of America (1983)
CHIBA, K, BIOCH BIOPHYS RES CO 120: 2 (1984). / BIOCH BIOPHYS RES CO (1984)
CHIBA, K, METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 120: 574 (1984). (10.1016/0006-291X(84)91293-2) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1984)
FORNO, L.S., MOVEMENT DISORD: 25 (1982). / MOVEMENT DISORD (1982)
Heikkila, R. E., Nature 311:467 (1984). (10.1038/311467a0) / Nature (1984)
LANGSTON, J.W., SELECTIVE NIGRAL TOXICITY AFTER SYSTEMIC ADMINISTRATION OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRINE (MPTP) IN THE SQUIRREL-MONKEY, BRAIN RESEARCH 292: 390 (1984). (10.1016/0006-8993(84)90777-7) / BRAIN RESEARCH (1984)
LANGSTON, J.W., PARKINSONISM INDUCED BY 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) - IMPLICATIONS FOR TREATMENT AND THE PATHOGENESIS OF PARKINSONS-DISEASE, CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES 11: 160 (1984). (10.1017/S0317167100046333) / CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES (1984)
Langston, J. W., Neuroscience Letters 50: 289 (1984). (10.1016/0304-3940(84)90501-9) / Neuroscience Letters (1984)
LANGSTON, J.W., 1-METHYL-4-PHENYLPYRIDINIUM ION (MPP+) - IDENTIFICATION OF A METABOLITE OF MPTP, A TOXIN SELECTIVE TO THE SUBSTANTIA NIGRA, NEUROSCIENCE LETTERS 48: 87 (1984). (10.1016/0304-3940(84)90293-3) / NEUROSCIENCE LETTERS (1984)
10.1126/science.6823561
YAHR, M.D., OVERVIEW OF PRESENT-DAY TREATMENT OF PARKINSONS-DISEASE, JOURNAL OF NEURAL TRANSMISSION 43: 227 (1978). (10.1007/BF01246959) / JOURNAL OF NEURAL TRANSMISSION (1978)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:41 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:52 p.m.)
Indexed	3 weeks, 3 days ago (Aug. 7, 2025, 4:46 p.m.)
Issued	40 years, 11 months ago (Sept. 28, 1984)
Published	40 years, 11 months ago (Sept. 28, 1984)
Published Print	40 years, 11 months ago (Sept. 28, 1984)

Funders 0

None

BibTeX

@article{Langston_1984, title={Pargyline Prevents MPTP-Induced Parkinsonism in Primates}, volume={225}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6332378}, DOI={10.1126/science.6332378}, number={4669}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Langston, J. William and Irwin, Ian and Langston, Elizabeth B. and Forno, Lysia S.}, year={1984}, month=sep, pages={1480–1482} }

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