DOI: 10.1126/science.6320373. Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor

Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor

10.1126/science.6320373

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The complete amino acid sequence of rat transforming growth factor type 1 has been determined. This growth factor, obtained from retrovirus-transformed fibroblasts, is structurally and functionally related to mouse epidermal growth factor and human urogastrone. Production of this polypeptide by various neoplastic cells might contribute to the continued expression of the transformed phenotype.

Bibliography

Marquardt, H., Hunkapiller, M. W., Hood, L. E., & Todaro, G. J. (1984). Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor. Science, 223(4640), 1079â1082.

Authors 4

Hans Marquardt (first)
Michael W. Hunkapiller (additional)
Leroy E. Hood (additional)
George J. Todaro (additional)

References 31 Referenced 465

Bennett, H. P. J., Proceedings of the American Peptide Symposium: 121 (1979). / Proceedings of the American Peptide Symposium (1979)
CARPENTER, G, THE BIOCHEMISTRY AND PHYSIOLOGY OF THE RECEPTOR-KINASE FOR EPIDERMAL GROWTH-FACTOR, MOLECULAR AND CELLULAR ENDOCRINOLOGY 31: 1 (1983). (10.1016/0303-7207(83)90027-8) / MOLECULAR AND CELLULAR ENDOCRINOLOGY (1983)
Dayhoff M. O. Protein Sequence Database (1983).
DELARCO, J.E., SARCOMA GROWTH-FACTOR FROM MOUSE SARCOMA VIRUS-TRANSFORMED CELLS - PURIFICATION BY BINDING AND ELUTION FROM EPIDERMAL GROWTH-FACTOR RECEPTOR-RICH CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 255: 3685 (1980). (10.1016/S0021-9258(19)85758-7) / JOURNAL OF BIOLOGICAL CHEMISTRY (1980)
DELARCO, J.E., EPITHELIOID AND FIBROBLASTIC RAT-KIDNEY CELL CLONES - EPIDERMAL GROWTH-FACTOR (EGF) RECEPTORS AND EFFECT OF MOUSE SARCOMA-VIRUS TRANSFORMATION, JOURNAL OF CELLULAR PHYSIOLOGY 94: 335 (1978). (10.1002/jcp.1040940311) / JOURNAL OF CELLULAR PHYSIOLOGY (1978)
DELARCO, J.E., SARCOMA GROWTH-FACTOR (SGF) - SPECIFIC BINDING TO EPIDERMAL GROWTH-FACTOR (EGF) MEMBRANE-RECEPTORS, JOURNAL OF CELLULAR PHYSIOLOGY 102: 267 (1980). (10.1002/jcp.1041020218) / JOURNAL OF CELLULAR PHYSIOLOGY (1980)
DELARCO, J.E., PROPERTIES OF A SARCOMA-GROWTH-FACTOR-LIKE PEPTIDE FROM CELLS TRANSFORMED BY A TEMPERATURE-SENSITIVE SARCOMA-VIRUS, JOURNAL OF CELLULAR PHYSIOLOGY 109: 143 (1981). (10.1002/jcp.1041090116) / JOURNAL OF CELLULAR PHYSIOLOGY (1981)
GIARD, D.J., IN-VITRO CULTIVATION OF HUMAN TUMORS - ESTABLISHMENT OF CELL LINES DERIVED FROM A SERIES OF SOLID TUMORS, JOURNAL OF THE NATIONAL CANCER INSTITUTE 51: 1417 (1973). (10.1093/jnci/51.5.1417) / JOURNAL OF THE NATIONAL CANCER INSTITUTE (1973)
GRAY, A, NUCLEOTIDE-SEQUENCE OF EPIDERMAL GROWTH-FACTOR CDNA PREDICTS A 128,000-MOLECULAR WEIGHT PROTEIN-PRECURSOR, NATURE 303: 722 (1983). (10.1038/303722a0) / NATURE (1983)
GREGORY, H, ISOLATION AND STRUCTURE OF UROGASTRONE AND ITS RELATIONSHIP TO EPIDERMAL GROWTH-FACTOR, NATURE 257: 325 (1975). (10.1038/257325a0) / NATURE (1975)
Haigler, H. T., Growth and Maturation Factors 1: 117 (1983). / Growth and Maturation Factors (1983)
HEWICK, R.M., A GAS-LIQUID SOLID-PHASE PEPTIDE AND PROTEIN SEQUENATOR, JOURNAL OF BIOLOGICAL CHEMISTRY 256: 7990 (1981). (10.1016/S0021-9258(18)43377-7) / JOURNAL OF BIOLOGICAL CHEMISTRY (1981)
10.1126/science.6687410
HUNTER, W.M., PREPARATION OF IODINE-131 LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC ACTIVITY, NATURE 194: 495 (1962). (10.1038/194495a0) / NATURE (1962)
KAPLAN, P.L., CELLULAR RESPONSIVENESS TO GROWTH-FACTORS CORRELATES WITH A CELLS ABILITY TO EXPRESS THE TRANSFORMED PHENOTYPE, CELL 33: 931 (1983). (10.1016/0092-8674(83)90036-3) / CELL (1983)
Kaplan, P. L., Proceedings of the National Academy of Sciences of the United States of America 79: 485 (1982). / Proceedings of the National Academy of Sciences of the United States of America (1982)
KITOS, P.A., GLUTAMINE METABOLISM BY ANIMAL CELLS GROWING IN A SYNTHETIC MEDIUM, EXPERIMENTAL CELL RESEARCH 27: 307 (1962). (10.1016/0014-4827(62)90233-1) / EXPERIMENTAL CELL RESEARCH (1962)
MARQUARDT, H, HUMAN TRANSFORMING GROWTH-FACTOR - PRODUCTION BY A MELANOMA CELL-LINE, PURIFICATION, AND INITIAL CHARACTERIZATION, JOURNAL OF BIOLOGICAL CHEMISTRY 257: 5220 (1982). (10.1016/S0021-9258(18)34658-1) / JOURNAL OF BIOLOGICAL CHEMISTRY (1982)
Marquardt, H., Proceedings of the National Academy of Sciences of the United States of America 80: 4684 (1983). / Proceedings of the National Academy of Sciences of the United States of America (1983)
Pike, L. J., Journal of Biological Chemistry 257: 14628 (1982). (10.1016/S0021-9258(18)33325-8) / Journal of Biological Chemistry (1982)
RAFF, M.C., SCHWANN CELL-GROWTH FACTORS, CELL 15: 813 (1978). (10.1016/0092-8674(78)90266-0) / CELL (1978)
REYNOLDS, F.H., HUMAN TRANSFORMING GROWTH-FACTORS INDUCE TYROSINE PHOSPHORYLATION OF EGF RECEPTORS, NATURE 292: 259 (1981). (10.1038/292259a0) / NATURE (1981)
SAVAGE, C.R., EPIDERMAL GROWTH-FACTOR AND A NEW DERIVATIVE - RAPID ISOLATION PROCEDURES AND BIOLOGICAL AND CHEMICAL CHARACTERIZATION, JOURNAL OF BIOLOGICAL CHEMISTRY 247: 7609 (1972). (10.1016/S0021-9258(19)44568-7) / JOURNAL OF BIOLOGICAL CHEMISTRY (1972)
SAVAGE, C.R., EPIDERMAL GROWTH-FACTOR - LOCATION OF DISULFIDE BONDS, JOURNAL OF BIOLOGICAL CHEMISTRY 248: 7669 (1973). (10.1016/S0021-9258(19)43242-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1973)
SAVAGE, C.R., PRIMARY STRUCTURE OF EPIDERMAL GROWTH-FACTOR, JOURNAL OF BIOLOGICAL CHEMISTRY 247: 7612 (1972). (10.1016/S0021-9258(19)44569-9) / JOURNAL OF BIOLOGICAL CHEMISTRY (1972)
10.1126/science.6602382
SPORN, M.B., AUTOCRINE SECRETION AND MALIGNANT TRANSFORMATION OF CELLS, NEW ENGLAND JOURNAL OF MEDICINE 303: 878 (1980). (10.1056/NEJM198010093031511) / NEW ENGLAND JOURNAL OF MEDICINE (1980)
TAM J.P. unpublished data.
Todaro, G. J., Tumor Cell Heterogeneity: Origins and Implications 4: 205 (1982). / Tumor Cell Heterogeneity: Origins and Implications (1982)
10.1126/science.6177040
TWARDZIK, D.R., SIMILAR TRANSFORMING GROWTH-FACTORS (TGFS) PRODUCED BY CELLS TRANSFORMED BY DIFFERENT ISOLATES OF FELINE SARCOMA-VIRUS, VIROLOGY 124: 201 (1983). (10.1016/0042-6822(83)90307-0) / VIROLOGY (1983)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:41 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:02 p.m.)
Indexed	1 month, 1 week ago (July 14, 2025, 11:23 p.m.)
Issued	41 years, 5 months ago (March 9, 1984)
Published	41 years, 5 months ago (March 9, 1984)
Published Print	41 years, 5 months ago (March 9, 1984)

Funders 0

None

BibTeX

@article{Marquardt_1984, title={Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor}, volume={223}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6320373}, DOI={10.1126/science.6320373}, number={4640}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Marquardt, Hans and Hunkapiller, Michael W. and Hood, Leroy E. and Todaro, George J.}, year={1984}, month=mar, pages={1079–1082} }

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