DOI: 10.1126/science.6310748. 1,25-Dihydroxyvitamin D <sub>3</sub> Receptors in Human Leukocytes

1,25-Dihydroxyvitamin D 3 Receptors in Human Leukocytes

10.1126/science.6310748

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A 1,25-dihydroxyvitamin D 3 receptor macromolecule was detected in peripheral mononuclear leukocytes from normal humans. This macromolecule was found to be present in monocytes but absent from normal resting peripheral B and T lymphocytes. However, it was present in established lines of malignant B, T, and non-B, non-T human lymphocytes, as well as in T and B lymphocytes obtained from normal humans and activated in vitro.

Bibliography

Provvedini, D. M., Tsoukas, C. D., Deftos, L. J., & Manolagas, S. C. (1983). 1,25-Dihydroxyvitamin D 3 Receptors in Human Leukocytes. Science, 221(4616), 1181â1183.

Authors 4

D. M. Provvedini (first)
C. D. Tsoukas (additional)
L. J. Deftos (additional)
S. C. Manolagas (additional)

References 24 Referenced 816

Abe, E., Proceedings of the National Academy of Sciences of the United States of America 78: 4990 (1981). / Proceedings of the National Academy of Sciences of the United States of America (1981)
ASH, P, OSTEOCLASTS DERIVED FROM HEMATOPOIETIC STEM-CELLS, NATURE 283: 669 (1980). (10.1038/283669a0) / NATURE (1980)
BEARD, J, J IMMUNOL 124: 1943 (1980). (10.4049/jimmunol.124.4.1943) / J IMMUNOL (1980)
BONUCCI, E, CLINICAL ORTHOPAEDICS AND RELATED RESEARCH 158: 252 (1981). / CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (1981)
BOYUM, A, ISOLATION OF MONONUCLEAR CELLS AND GRANULOCYTES FROM HUMAN BLOOD - ISOLATION OF MONONUCLEAR CELLS BY ONE CENTRIFUGATION AND OF GRANULOCYTES BY COMBINING CENTRIFUGATION AND SEDIMENTATION AT L G, SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 21: 77 (1968). (10.3109/00365516809076979) / SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (1968)
BURGER, E.H., INVITRO FORMATION OF OSTEOCLASTS FROM LONG-TERM CULTURES OF BONE-MARROW MONONUCLEAR PHAGOCYTES, JOURNAL OF EXPERIMENTAL MEDICINE 156: 1604 (1982). (10.1084/jem.156.6.1604) / JOURNAL OF EXPERIMENTAL MEDICINE (1982)
GMELIGMEYLING, F, SEPARATION OF HUMAN-BLOOD MONOCYTES AND LYMPHOCYTES ON A CONTINUOUS PERCOLL GRADIENT, JOURNAL OF IMMUNOLOGICAL METHODS 33: 1 (1980). (10.1016/0022-1759(80)90077-0) / JOURNAL OF IMMUNOLOGICAL METHODS (1980)
HAUSSLER, M.R., BASIC AND CLINICAL CONCEPTS RELATED TO VITAMIN-D METABOLISM AND ACTION .1., NEW ENGLAND JOURNAL OF MEDICINE 297: 974 (1977). (10.1056/NEJM197711032971804) / NEW ENGLAND JOURNAL OF MEDICINE (1977)
Honma, Y., Proceedings of the National Academy of Sciences of the United States of America 80: 201 (1983). / Proceedings of the National Academy of Sciences of the United States of America (1983)
LEE, SHS, REVERSIBLE INHIBITION BY INTERFERON OF THE MATURATION OF HUMAN PERIPHERAL-BLOOD MONOCYTES TO MACROPHAGES, CELLULAR IMMUNOLOGY 50: 177 (1980). (10.1016/0008-8749(80)90016-7) / CELLULAR IMMUNOLOGY (1980)
MANOLAGAS, S.C., STUDIES OF THE INTERNALIZATION OF VITAMIN-D3 METABOLITES BY CULTURED OSTEOGENIC-SARCOMA CELLS AND THEIR APPLICATION TO A NON-CHROMATOGRAPHIC CYTORECEPTOR ASSAY FOR 1,25-DIHYDROXYVITAMIN-D3, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 95: 596 (1980). (10.1016/0006-291X(80)90826-8) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1980)
MANOLAGAS, S.C., COMPARISON OF 1,25-HYDROXYLATED, 25-HYDROXYLATED AND 24,25-HYDROXYLATED VITAMIN-D3 BINDING IN FETAL-RAT CALVARIAE AND OSTEOGENIC-SARCOMA CELLS, CALCIFIED TISSUE INTERNATIONAL 33: 655 (1981). (10.1007/BF02409504) / CALCIFIED TISSUE INTERNATIONAL (1981)
MANOLAGAS, S.C., 1,25-DIHYDROXYVITAMIN-D3 RECEPTOR-LIKE MACROMOLECULE IN RAT OSTEOGENIC-SARCOMA CELL-LINES, JOURNAL OF BIOLOGICAL CHEMISTRY 255: 4414 (1980). (10.1016/S0021-9258(19)85505-9) / JOURNAL OF BIOLOGICAL CHEMISTRY (1980)
MINOWADA, J, EXPRESSION OF AN ANTIGEN ASSOCIATED WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN HUMAN LEUKEMIA-LYMPHOMA CELL LINES, JOURNAL OF THE NATIONAL CANCER INSTITUTE 60: 1269 (1978). (10.1093/jnci/60.6.1269) / JOURNAL OF THE NATIONAL CANCER INSTITUTE (1978)
MIYAURA, C, 1-ALPHA, 25-DIHYDROXYVITAMIN-D3 INDUCES DIFFERENTIATION OF HUMAN MYELOID-LEUKEMIA CELLS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 102: 937 (1981). (10.1016/0006-291X(81)91628-4) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1981)
ROYSTON, I, HUMAN T-CELL ANTIGENS DEFINED BY MONOCLONAL-ANTIBODIES - THE 65,000-DALTON ANTIGEN OF T-CELLS (T65) IS ALSO FOUND ON CHRONIC LYMPHOCYTIC-LEUKEMIA CELLS BEARING SURFACE-IMMUNOGLOBULIN, JOURNAL OF IMMUNOLOGY 125: 725 (1980). (10.4049/jimmunol.125.2.725) / JOURNAL OF IMMUNOLOGY (1980)
SALZMAN, G.C., CELL CLASSIFICATION BY LASER LIGHT-SCATTERING - IDENTIFICATION AND SEPARATION OF UNSTAINED LEUKOCYTES, ACTA CYTOLOGICA 19: 374 (1975). / ACTA CYTOLOGICA (1975)
STASHENKO, P, J IMMUNOL 125: 1506 (1980). (10.4049/jimmunol.125.4.1506) / J IMMUNOL (1980)
TEITELBAUM, S.L., MONONUCLEAR PHAGOCYTES, OSTEOCLASTS AND BONE-RESORPTION, MINERAL AND ELECTROLYTE METABOLISM 3: 2 (1980). / MINERAL AND ELECTROLYTE METABOLISM (1980)
TSOUKAS, C.D., SIMULTANEOUS SUPPRESSION OF ALLOGENEIC CYTOLYTIC ACTIVITY AND STIMULATION OF LECTIN-DEPENDENT CYTOLYTIC ACTIVITY BY CON-A, CELLULAR IMMUNOLOGY 40: 103 (1978). (10.1016/0008-8749(78)90319-2) / CELLULAR IMMUNOLOGY (1978)
TSOUKAS, C.D., LYMPHOCYTE-T-MEDIATED CYTO-TOXICITY AGAINST AUTOLOGOUS EBV-GENOME-BEARING B-CELLS, JOURNAL OF IMMUNOLOGY 126: 1742 (1981). (10.4049/jimmunol.126.5.1742) / JOURNAL OF IMMUNOLOGY (1981)
WINGER, L.A., SEQUENTIAL PROLIFERATION INDUCED IN HUMAN PERIPHERAL-BLOOD LYMPHOCYTES BY MITOGEN .2. SUPPRESSION BY PHA-ACTIVATED CELLS, JOURNAL OF IMMUNOLOGY 118: 1768 (1977). (10.4049/jimmunol.118.5.1768) / JOURNAL OF IMMUNOLOGY (1977)
Wong, R. G., Journal of Biological Chemistry 247: 5728 (1972). (10.1016/S0021-9258(19)44820-5) / Journal of Biological Chemistry (1972)
YAM, L.T., CYTOCHEMICAL IDENTIFICATION OF MONOCYTES AND GRANULOCYTES, AMERICAN JOURNAL OF CLINICAL PATHOLOGY 55: 283 (1971). (10.1093/ajcp/55.3.283) / AMERICAN JOURNAL OF CLINICAL PATHOLOGY (1971)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 2:37 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:02 p.m.)
Indexed	3 days, 19 hours ago (Aug. 28, 2025, 8:35 a.m.)
Issued	41 years, 11 months ago (Sept. 16, 1983)
Published	41 years, 11 months ago (Sept. 16, 1983)
Published Print	41 years, 11 months ago (Sept. 16, 1983)

Funders 0

None

BibTeX

@article{Provvedini_1983, title={1,25-Dihydroxyvitamin D 3 Receptors in Human Leukocytes}, volume={221}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6310748}, DOI={10.1126/science.6310748}, number={4616}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Provvedini, D. M. and Tsoukas, C. D. and Deftos, L. J. and Manolagas, S. C.}, year={1983}, month=sep, pages={1181–1183} }

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