DOI: 10.1126/science.6302841. Adenosine Receptors: Autoradiographic Evidence for Their Location on Axon Terminals of Excitatory Neurons

Adenosine Receptors: Autoradiographic Evidence for Their Location on Axon Terminals of Excitatory Neurons

10.1126/science.6302841

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Adenosine receptors were made visible on light microscopy by autoradiography with tritiated cyclohexyladenosine. In the cerebellum, adenosine receptors were absent in Weaver mice, which lack granule cells, and were displaced in Reeler mice, which have displacements of granule cells. Thus, adenosine receptors appear to be located on the axon terminals of excitatory granule cells in the cerebellum. Removal of one eye of a rat depleted adenosine receptors in the contralateral superior colliculus, suggesting that the receptors occur on axon terminals of excitatory projections from retinal ganglion cells. The presence of adenosine receptors on excitatory axon terminals may explain synaptic inhibition by adenosine and the behavioral effects of xanthines.

Bibliography

Goodman, R. R., Kuhar, M. J., Hester, L., & Snyder, S. H. (1983). Adenosine Receptors: Autoradiographic Evidence for Their Location on Axon Terminals of Excitatory Neurons. Science, 220(4600), 967â969.

Authors 4

Robert R. Goodman (first)
Michael J. Kuhar (additional)
Lynda Hester (additional)
Solomon H. Snyder (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 2:37 p.m.)
Deposited	7 months, 2 weeks ago (Jan. 11, 2025, 2:12 a.m.)
Indexed	2 months, 1 week ago (June 21, 2025, 2:02 a.m.)
Issued	42 years, 3 months ago (May 27, 1983)
Published	42 years, 3 months ago (May 27, 1983)
Published Print	42 years, 3 months ago (May 27, 1983)

Funders 0

None

BibTeX

@article{Goodman_1983, title={Adenosine Receptors: Autoradiographic Evidence for Their Location on Axon Terminals of Excitatory Neurons}, volume={220}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6302841}, DOI={10.1126/science.6302841}, number={4600}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Goodman, Robert R. and Kuhar, Michael J. and Hester, Lynda and Snyder, Solomon H.}, year={1983}, month=may, pages={967–969} }

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