DOI: 10.1126/science.6302839. Frequent Activation of c- <i>kis</i> as a Transforming Gene in Fibrosarcomas Induced by Methylcholanthrene

Frequent Activation of c- kis as a Transforming Gene in Fibrosarcomas Induced by Methylcholanthrene

10.1126/science.6302839

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The DNA's from two of four methylcholanthrene-induced mouse fibrosarcomas contained transforming genes that were identical in their pattern of restriction endonuclease resistance to inactivation of biologic activity. This transforming gene was identified as the activated homolog of the Kirsten murine sarcoma virus onc gene, v- kis . The finding that a defined carcinogen reproducibly leads to activation of kis as a transforming gene should be of value in elucidating the role of oncogenes in the neoplastic process.

Bibliography

Eva, A., & Aaronson, S. A. (1983). Frequent Activation of c- kis as a Transforming Gene in Fibrosarcomas Induced by Methylcholanthrene. Science, 220(4600), 955â956.

Authors 2

Alessandra Eva (first)
Stuart A. Aaronson (additional)

References 25 Referenced 62

AARONSON, S.A., CHARACTERIZATION OF MURINE SARCOMA VIRUS (KIRSTEN) TRANSFORMATION OF MOUSE AND HUMAN CELLS, JOURNAL OF GENERAL VIROLOGY 13: 245 (1971). (10.1099/0022-1317-13-2-245) / JOURNAL OF GENERAL VIROLOGY (1971)
AARONSON, S.A., ORIGIN AND BIOLOGICAL PROPERTIES OF A NEW BALB-C MOUSE SARCOMA-VIRUS, JOURNAL OF VIROLOGY 27: 366 (1978). (10.1128/jvi.27.2.366-373.1978) / JOURNAL OF VIROLOGY (1978)
COOPER, G.M., TRANSFORMING ACTIVITY OF DNA OF CHEMICALLY TRANSFORMED AND NORMAL-CELLS, NATURE 284: 418 (1980). (10.1038/284418a0) / NATURE (1980)
Der, C. J., Proceedings of the National Academy of Sciences of the United States of America 79: 3637 (1982). / Proceedings of the National Academy of Sciences of the United States of America (1982)
FUSCO, A, BLOCK IN THE EXPRESSION OF DIFFERENTIATION MARKERS OF RAT-THYROID EPITHELIAL-CELLS BY TRANSFORMATION WITH KIRSTEN MURINE SARCOMA-VIRUS, CANCER RESEARCH 42: 618 (1982). / CANCER RESEARCH (1982)
10.1016/0042-6822(73)90341-3
HANKINS, W.D., HARVEY AND KIRSTEN SARCOMA-VIRUSES PROMOTE THE GROWTH AND DIFFERENTIATION OF ERYTHROID PRECURSOR CELLS-INVITRO, CELL 26: 91 (1981). (10.1016/0092-8674(81)90036-2) / CELL (1981)
HARVEY, J.J., UNIDENTIFIED VIRUS WHICH CAUSES RAPID PRODUCTION OF TUMOURS IN MICE, NATURE 204: 1104 (1964). / NATURE (1964)
Hopkins, N., Proceedings of the National Academy of Sciences of the United States of America 78: 7555 (1981). / Proceedings of the National Academy of Sciences of the United States of America (1981)
JAINCHILL, J.L., MURINE SARCOMA AND LEUKEMIA VIRUSES - ASSAY USING CLONAL LINES OF CONTACT-INHIBITED MOUSE CELLS, JOURNAL OF VIROLOGY 4: 549 (1969). (10.1128/jvi.4.5.549-553.1969) / JOURNAL OF VIROLOGY (1969)
KIRSTEN, W.H., MORPHOLOGIC RESPONSES TO A MURINE ERYTHROBLASTOSIS VIRUS, JOURNAL OF THE NATIONAL CANCER INSTITUTE 39: 311 (1967). / JOURNAL OF THE NATIONAL CANCER INSTITUTE (1967)
LANE, M.A., ACTIVATION OF RELATED TRANSFORMING GENES IN MOUSE AND HUMAN MAMMARY CARCINOMAS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 78: 5185 (1981). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1981)
10.1038/297474a0
PETERS, R.L., NATURALLY OCCURRING SARCOMA-VIRUS OF BALB-CCR MOUSE, JOURNAL OF THE NATIONAL CANCER INSTITUTE 53: 1725 (1974). / JOURNAL OF THE NATIONAL CANCER INSTITUTE (1974)
PIERCE, J.H., BALB-MURINE AND HARVEY-MURINE SARCOMA-VIRUS TRANSFORMATION OF A NOVEL LYMPHOID PROGENITOR-CELL, JOURNAL OF EXPERIMENTAL MEDICINE 156: 873 (1982). (10.1084/jem.156.3.873) / JOURNAL OF EXPERIMENTAL MEDICINE (1982)
PULCIANI, S, ONCOGENES IN SOLID HUMAN-TUMORS, NATURE 300: 539 (1982). (10.1038/300539a0) / NATURE (1982)
Pulciani, S., Proceedings of the National Academy of Sciences of the United States of America 79: 2845 (1982). / Proceedings of the National Academy of Sciences of the United States of America (1982)
Santos, E., Nature 298:343 (1982). (10.1038/298343a0) / Nature (1982)
SCHER, C.D., INDUCTION OF ERYTHROID LEUKEMIA BY HARVEY AND KIRSTEN SARCOMA-VIRUSES, NATURE 256: 225 (1975). (10.1038/256225a0) / NATURE (1975)
10.1038/290261a0
SHIH, C, PASSAGE OF PHENOTYPES OF CHEMICALLY TRANSFORMED-CELLS VIA TRANSFECTION OF DNA AND CHROMATIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 5714 (1979). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1979)
SHILO, B.Z., UNIQUE TRANSFORMING GENE IN CARCINOGEN-TRANSFORMED MOUSE CELLS, NATURE 289: 607 (1981). (10.1038/289607a0) / NATURE (1981)
TSUCHIDA, N, STRUCTURE AND FUNCTIONS OF THE KIRSTEN MURINE SARCOMA-VIRUS GENOME - MOLECULAR-CLONING OF BIOLOGICALLY-ACTIVE KIRSTEN MURINE SARCOMA-VIRUS DNA, JOURNAL OF VIROLOGY 38: 720 (1981). (10.1128/jvi.38.2.720-727.1981) / JOURNAL OF VIROLOGY (1981)
Weissman, B. E., Cell 32: 599 (1983). (10.1016/0092-8674(83)90479-8) / Cell (1983)
WIGLER, M, TRANSFER OF PURIFIED HERPES-VIRUS THYMIDINE KINASE GENE TO CULTURED MOUSE CELLS, CELL 11: 223 (1977). (10.1016/0092-8674(77)90333-6) / CELL (1977)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 2:37 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:37 p.m.)
Indexed	1 month ago (July 26, 2025, 5:15 a.m.)
Issued	42 years, 3 months ago (May 27, 1983)
Published	42 years, 3 months ago (May 27, 1983)
Published Print	42 years, 3 months ago (May 27, 1983)

Funders 0

None

BibTeX

@article{Eva_1983, title={Frequent Activation of c- kis as a Transforming Gene in Fibrosarcomas Induced by Methylcholanthrene}, volume={220}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6302839}, DOI={10.1126/science.6302839}, number={4600}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Eva, Alessandra and Aaronson, Stuart A.}, year={1983}, month=may, pages={955–956} }

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