Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation
10.1126/science.6301011
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4and E4by successive elimination of a γ-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.

Bibliography

Samuelsson, B. (1983). Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation. Science, 220(4597), 568–575.

Authors 1
  1. Bengt Samuelsson (first)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 2:37 p.m.)
Deposited 7 months, 3 weeks ago (Jan. 11, 2025, 2:10 a.m.)
Indexed 4 days, 4 hours ago (Aug. 28, 2025, 8:51 a.m.)
Issued 42 years, 3 months ago (May 6, 1983)
Published 42 years, 3 months ago (May 6, 1983)
Published Print 42 years, 3 months ago (May 6, 1983)
Funders 0

None

@article{Samuelsson_1983, title={Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation}, volume={220}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6301011}, DOI={10.1126/science.6301011}, number={4597}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Samuelsson, Bengt}, year={1983}, month=may, pages={568–575} }