DOI: 10.1126/science.6293056. Eukaryotic Transcriptional Regulation and Chromatin-Associated Protein Phosphorylation by Cyclic AMP

Eukaryotic Transcriptional Regulation and Chromatin-Associated Protein Phosphorylation by Cyclic AMP

10.1126/science.6293056

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Cyclic adenosine monophosphate (AMP) analogs or agents that increase intracellular cyclic AMP rapidly stimulate transcription of the prolactin gene in a line of cultured rat pituitary cells. This effect is correlated with the phosphorylation of a chromatin-associated basic protein designated BRP. These data are consistent with the postulate that increased intracellular cyclic AMP concentrations induce rapid transcriptional effects on specific genes in eukaryotes, mediated by direct or indirect phosphorylation of a specific chromatin-associated protein or proteins.

Bibliography

Murdoch, G. H., Rosenfeld, M. G., & Evans, R. M. (1982). Eukaryotic Transcriptional Regulation and Chromatin-Associated Protein Phosphorylation by Cyclic AMP. Science, 218(4579), 1315â1317.

Authors 3

Geoffrey H. Murdoch (first)
Michael G. Rosenfeld (additional)
Ronald M. Evans (additional)

References 37 Referenced 107

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:22 p.m.)
Indexed	1 year, 7 months ago (Jan. 18, 2024, 1:40 a.m.)
Issued	42 years, 8 months ago (Dec. 24, 1982)
Published	42 years, 8 months ago (Dec. 24, 1982)
Published Print	42 years, 8 months ago (Dec. 24, 1982)

Funders 0

None

BibTeX

@article{Murdoch_1982, title={Eukaryotic Transcriptional Regulation and Chromatin-Associated Protein Phosphorylation by Cyclic AMP}, volume={218}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6293056}, DOI={10.1126/science.6293056}, number={4579}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Murdoch, Geoffrey H. and Rosenfeld, Michael G. and Evans, Ronald M.}, year={1982}, month=dec, pages={1315–1317} }

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